Ig-alpha/CD79a
Ig-alpha (CD79a, MB-1) is the heavier of the two disulfide-linked chains of the B-cell receptor signaling complex. It contains one extracellular Ig-like domain that contacts the immunoglobulin heavy chain, and a cytoplasmic tail with a single ITAM that, once phosphorylated by Lyn and related Src kinases, initiates the Syk-BLNK cascade. Together with Ig-beta it is indispensable for surface immunoglobulin assembly, and germline CD79A mutations cause agammaglobulinemia with absent B cells. As a pan-B-cell antigen retained in many neoplasms, CD79a is the standard immunohistochemistry marker of B-cell lineage, and the CD79b-directed conjugate polatuzumab vedotin exploits the same complex clinically.
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Ig-alpha/CD79a Recombinant Proteins (7)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
