Signaling Pathway

5-Lipoxygenase

5-Lipoxygenase

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5-lipoxygenase (5-LOX or 5-LO) is an enzyme that in humans is encoded by the ALOX5 gene. 5-lipoxygenase is a member of the lipoxygenase family of enzymes. It transforms EFAs into leukotrienes and is a current target for pharmaceutical intervention in a number of diseases. 5-LO catalyzes oxidation of AA at the 5-position to yield 5-HpETE. 5-LO then converts 5-HpETE to leukotriene A4. Recently, oxidized lipid products of 5-LO have been measured in membranes of neutrophils in the form of esterified-5-HETE phospholipids. These novel products have biological activities including inhibition of neutrophil extracellular traps. 5-LO is a target for pharmaceutical intervention in CAD. Some people with variant alleles for 5-LO are at elevated risk for CAD. 5-LO is expressed in brain cells and may participate in neuropathologic processes.

5-Lipoxygenase Inhibitors & Modulators (5)

Product Name Catalog No. Brief Description
Malotilate

HY-A0060

Malotilate is a liver protein metabolism improved compound, which selectively inhibit the 5-lipoxygenase.

ML355

HY-12341

ML355 is a potent and selective inhibitors of 12-Lipoxygenase(12-LOX) with IC50 of 0.34 uM, excellent selectivity over related lipoxygenases and cyclooxygenases, and possess favorable ADME properties.

U-73122

HY-13419

U-73122 is an inhibitor of phospholipase C, phospholipase A2, and 5-LO (5-lipoxygenase).

Zileuton

HY-14164

Description:
IC50 Value: N/A
zileuton(N-1(1-benzo[b]thien-2-ylethyl)-N-hydroxyurea, A-64077) is a selective and potent 5-LO inhibitor, and thus inhibits leukotrienes (LTB4, LTC4, LTD4, and LTE4) formation.

Zileuton sodium

HY-14164A

Zileuton (sodium) is an orally active inhibitor of 5-lipoxygenase, and thus inhibits leukotrienes (LTB4, LTC4, LTD4, and LTE4) formation.