1. Metabolic Enzyme/Protease
  2. 5-Lipoxygenase

5-Lipoxygenase

5-Lipoxygenase (5-LOX or 5-LO) is an enzyme that in humans is encoded by the ALOX5 gene. 5-lipoxygenase is a member of the lipoxygenase family of enzymes. It transforms EFAs into leukotrienes and is a current target for pharmaceutical intervention in a number of diseases. 5-LO catalyzes oxidation of AA at the 5-position to yield 5-HpETE. 5-LO then converts 5-HpETE to leukotriene A4. Recently, oxidized lipid products of 5-LO have been measured in membranes of neutrophils in the form of esterified-5-HETE phospholipids. These novel products have biological activities including inhibition of neutrophil extracellular traps. 5-LO is a target for pharmaceutical intervention in CAD. Some people with variant alleles for 5-LO are at elevated risk for CAD. 5-LO is expressed in brain cells and may participate in neuropathologic processes.

5-Lipoxygenase Related Products (26):

Cat. No. Product Name Effect Purity
  • HY-13419
    U-73122 Inhibitor 98.17%
    U-73122 is an inhibitor of phospholipase C (PLC), phospholipase A2, and 5-LO (5-lipoxygenase).
  • HY-14164
    Zileuton Inhibitor 99.93%
    Zileuton is a potent and selective inhibitor of 5-lipoxygenase, exhibiting inflammatory activities.
  • HY-12341
    ML355 Inhibitor 98.28%
    ML355 is a potent and selective inhibitors of 12-Lipoxygenase(12-LOX) with IC50 of 0.34 μM, excellent selectivity over related lipoxygenases and cyclooxygenases, and possess favorable ADME properties.
  • HY-N0198
    Nordihydroguaiaretic acid Inhibitor 99.78%
    Nordihydroguaiaretic acid is a 5-lipoxygenase (5LOX) (IC50=8±3 μM) and tyrosine kinase inhibitor.
  • HY-19807
    Indirubin-3'-monoxime Inhibitor 99.70%
    Indirubin-3'-monoxime is a potent GSK-3β inhibitor, and weakly inhibits 5-Lipoxygenase, with IC50s of 22 nM and 7.8-10 µM, respectively; Indirubin-3'-monoxime also shows inhibitory activities against CDK5/p25 and CDK1/cyclin B, with IC50s of 100 and 180 nM.
  • HY-101945
    A-69412 Inhibitor
    A-69412 is a reversible, specific inhibitor of the hydrophilic 5-lipoxygenase (5-LO).
  • HY-110399
    Cirsiliol Inhibitor
    Cirsiliol is a potent and selective 5-lipoxygenase inhibitor and a competitive low affinity benzodiazepine receptor ligand.
  • HY-N1881
    4',5-Dihydroxyflavone Inhibitor
    4',5-Dihydroxyflavone is a soybean LOX-1 and yeast α-Glucosidase inhibitor, with an Ki of 102.6 μM for soybean LOX-1 and an IC50 of 66 μM for yeast α-glucosidase.
  • HY-N0172
    Caffeic acid Inhibitor 98.80%
    Caffeic acid is an inhibitor of both TRPV1 ion channel and 5-Lipoxygenase (5-LO).
  • HY-N2176
    S-(+)-Marmesin Inhibitor 99.04%
    S-(+)-Marmesin is a natural coumarin, exhibiting COX-2/5-LOX dual inhibitory activity.
  • HY-A0060
    Malotilate Inhibitor 99.54%
    Malotilate is a liver protein metabolism improved compound, which selectively inhibit the 5-lipoxygenase.
  • HY-14164A
    Zileuton sodium Inhibitor
    Zileuton sodium is a potent and selective inhibitor of 5-lipoxygenase, exhibiting inflammatory activities.
  • HY-U00024
    Enazadrem Inhibitor
    Enazadrem is a 5-lipoxygenase inhibitor with antiinflammatory activities.
  • HY-100148
    ICI 211965 Inhibitor
    ICI 211965 is a selective and orally potent 5-Lipoxygenase (5-LPO) inhibitor.
  • HY-U00438
    LP117 Inhibitor
    LP117 is a novel and potent inhibitor of 5-Lipoxygenase (5-LO) product synthesis with an IC50 of 1.1 μM.
  • HY-101579
    LY 178002 Antagonist
    LY 178002 is a potent inhibitor of cyclooxygenase, 5-1ipoxygenase, phospholipase A2 and cellular production of LTB4 by human polymorphonuclear leukocytes, with IC50 of 0.6 μM for 5-1ipoxygenase.
  • HY-U00022
    RWJ 63556 Inhibitor
    RWJ 63556 is an orally active COX-2 selective/5-lipoxygenase inhibitor, with anti-inflammatory activities.
  • HY-19212
    S-2474 Inhibitor
    S-2474 is an inhibitor of COX-2 and 5-lipoxygenase, and used as a nonsteroidal anti-inflammatory drug.
  • HY-U00260
    CMI977 Inhibitor
    CMI977 is a potent 5-Lipoxygenase (5-LO) inhibitor.
  • HY-U00347
    COX/5-LO-IN-1 Inhibitor
    COX/5-LO-IN-1 is an inhibitor of cylooxygenase and 5-lipoxygenase, used for the research of inflammatory and allergic disease states.
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