Cat. No.: HY-N0198

Nordihydroguaiaretic acid

Name: Nordihydroguaiaretic acid
Brand: MedChemExpress
SKU: HY-N0198
Price: 60.00 USD
Availability: InStock
Rating: 5 (8 reviews)

(Synonyms: NDGA)

8 Cited Publications

Customer Review

Based on 8 publication(s) in Google Scholar

Nordihydroguaiaretic acid is a 5-lipoxygenase (5LOX) (IC₅₀=8 μM) and tyrosine kinase inhibitor.

For research use only. We do not sell to patients.

Purity: 99.93%
CAS No.: 500-38-9
Formula: C₁₈H₂₂O₄
Molecular Weight:302.36

Storage:

Store at room temperature 3 years.

In solvent -80°C, 2 years , -20°C, 1 year

Nordihydroguaiaretic acid Chemical Structure

CAS No.: 500-38-9

Size

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
- Clinical Trial
Chemical Information
Publications (8)
Solvent & Solubility
- In Vitro
- In Vivo
Protocol
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Nordihydroguaiaretic acid is a 5-lipoxygenase (5LOX) (IC₅₀=8 μM) and tyrosine kinase inhibitor.

IC₅₀ & Target^[1]

5-LOX

8 μM (IC₅₀)

All Lipoxygenase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A-375	IC₅₀	230 μM Compound: NDGA	Cytotoxicity against human A375 cells assessed as inhibition of DNA synthesis at 50 uM Cytotoxicity against human A375 cells assessed as inhibition of DNA synthesis at 50 uM	[PMID: 19615898]
A-375	IC₅₀	54.3 μM Compound: NDGA	Cytotoxicity against human A375 cells after 5 days by MTT assay Cytotoxicity against human A375 cells after 5 days by MTT assay	[PMID: 19615898]
BGC-823	IC₅₀	>60 μM Compound: NDGA	Antiproliferative activity against human BGC823 cells after 72 hrs by MTT assay Antiproliferative activity against human BGC823 cells after 72 hrs by MTT assay	[PMID: 27829519]
HEK293	EC₅₀	35 μM Compound: NDGA	Agonist activity at human TRPA1 expressed in HEK293 cells assessed as increase in calcium influx by Fluo-4-AM dye based fluorescence assay Agonist activity at human TRPA1 expressed in HEK293 cells assessed as increase in calcium influx by Fluo-4-AM dye based fluorescence assay	[PMID: 30878828]
HEK293	EC₅₀	4.9 μM Compound: NDGA	Agonist activity at human TRPA1 expressed in HEK293 cells assessed as increase in calcium influx by Calcium-5 dye based fluorescence assay Agonist activity at human TRPA1 expressed in HEK293 cells assessed as increase in calcium influx by Calcium-5 dye based fluorescence assay	[PMID: 30878828]
HeLa	IC₅₀	0.08 μg/mL Compound: NDGA	Antiallergic activity in Ca(2+)-stimulated differentiated human HeLa cells assessed as inhibition of cys-leukotriene release after 6 days by ELISA Antiallergic activity in Ca(2+)-stimulated differentiated human HeLa cells assessed as inhibition of cys-leukotriene release after 6 days by ELISA	[PMID: 19942440]
Hepatocyte	IC₅₀	3 x 10⁴ nM Compound: Nordihydroguaiaretic acid	Antimicrobial activity against Plasmodium yoelii 265 liver infected in mammalian hepatocytes after 48 hrs Antimicrobial activity against Plasmodium yoelii 265 liver infected in mammalian hepatocytes after 48 hrs	[PMID: 18212104]
HepG2	IC₅₀	54.1 μM Compound: NDGA	Cytotoxicity against human HepG2 cells after 5 days by MTT assay Cytotoxicity against human HepG2 cells after 5 days by MTT assay	[PMID: 19615898]
HL-60	IC₅₀	12.2 μM Compound: NDGA	Cytotoxicity against human HL60 cells by XTT assay Cytotoxicity against human HL60 cells by XTT assay	[PMID: 16562834]
HL-60	IC₅₀	2.3 μM Compound: NDGA	Antioxidant activity in human HL60 cells assessed as inhibition of TPA-stimulated hydrogen peroxide induced DCFH-DA oxidation by fluorometric microplate assay Antioxidant activity in human HL60 cells assessed as inhibition of TPA-stimulated hydrogen peroxide induced DCFH-DA oxidation by fluorometric microplate assay	[PMID: 16562834]
HT-29	IC₅₀	51.3 μM Compound: NDGA	Cytotoxicity against human HT-29 cells after 5 days by MTT assay Cytotoxicity against human HT-29 cells after 5 days by MTT assay	[PMID: 19615898]
L929	EC₅₀	19 μM Compound: nordihydroguaiaretic acid	Inhibition of recombinant human TNF-alpha-induced cytotoxicity of mouse L929 cells assessed as survivality preincubated for 15 mins before TNFalpha addition measured after 24 hrs by [methyl-3H]thymidine incorporation assay Inhibition of recombinant human TNF-alpha-induced cytotoxicity of mouse L929 cells assessed as survivality preincubated for 15 mins before TNFalpha addition measured after 24 hrs by [methyl-3H]thymidine incorporation assay	[PMID: 9287415]
L929	EC₅₀	28 μM Compound: nordihydroguaiaretic acid	Inhibition of recombinant human TNF-alpha-induced cytotoxicity of mouse L929 cells assessed as survivality preincubated for 15 mins before TNFalpha addition measured after 24 hrs by crystal violet staining Inhibition of recombinant human TNF-alpha-induced cytotoxicity of mouse L929 cells assessed as survivality preincubated for 15 mins before TNFalpha addition measured after 24 hrs by crystal violet staining	[PMID: 9287415]
LNCaP	IC₅₀	38.8 μM Compound: 4, ZINC00012342, Nordihydroguaiaretic acid	Transcriptional activity at human androgen receptor BF3 site stably transfected in eGFP-expressing human LNCAP cells after 5 days by fluorometric analysis Transcriptional activity at human androgen receptor BF3 site stably transfected in eGFP-expressing human LNCAP cells after 5 days by fluorometric analysis	[PMID: 22047606]
Macrophage	IC₅₀	6 μM Compound: NDGA	Antiinflammatory activity in NMRI mouse macrophages assessed as inhibition of A23187-induced LTC4 release by Ellman's method Antiinflammatory activity in NMRI mouse macrophages assessed as inhibition of A23187-induced LTC4 release by Ellman's method	[PMID: 8988605]
Macrophage	IC₅₀	6 μmol Compound: NDGA	Antiinflammatory activity in NMRI mouse macrophages assessed as inhibition of A23187-induced LTC4 release by Ellman's method Antiinflammatory activity in NMRI mouse macrophages assessed as inhibition of A23187-induced LTC4 release by Ellman's method	[PMID: 8988605]
MCF7	IC₅₀	24.6 μM Compound: NDGA	Inhibition of IGF1 mediated cell growth in MCF7 cells Inhibition of IGF1 mediated cell growth in MCF7 cells	[PMID: 17502145]
MCF7	IC₅₀	8.5 μM Compound: NDGA	Cytotoxicity against human MCF7 cells after 5 days by MTT assay Cytotoxicity against human MCF7 cells after 5 days by MTT assay	[PMID: 19615898]
MGC-803	IC₅₀	45.8 μM Compound: NDGA	Antiproliferative activity against human MGC803 cells after 72 hrs by MTT assay Antiproliferative activity against human MGC803 cells after 72 hrs by MTT assay	[PMID: 27829519]
NCI-H69	IC₅₀	4.4 μM Compound: NDGA	Cytotoxicity against human H69 cells Cytotoxicity against human H69 cells	[PMID: 24080463]
PMNL	IC₅₀	0.4 μM Compound: nordihydroguaiaretic acid	Inhibition of LTB4 biosynthesis in A-23187-stimulated bovine PMNL cells Inhibition of LTB4 biosynthesis in A-23187-stimulated bovine PMNL cells	[PMID: 10395494]
RBL-1	IC₅₀	0.41 μM Compound: NDGA	In vitro inhibitory concentration against 5-lipoxygenase in RBL-1 cells In vitro inhibitory concentration against 5-lipoxygenase in RBL-1 cells	[PMID: 11277534]
RBL-1	IC₅₀	0.15 μM Compound: NDGA (Nordihydroguaiaretic aid)	Ability to inhibit 5-lipoxygenase by using a crude preparation of the cytosolic enzyme from the rat basophilic leukemia (RBL-1) cell line Ability to inhibit 5-lipoxygenase by using a crude preparation of the cytosolic enzyme from the rat basophilic leukemia (RBL-1) cell line	[PMID: 2104936]
RBL-1	IC₅₀	0.14 μM Compound: NDGA	In vitro inhibition of RBL-1 5-lipoxygenase In vitro inhibition of RBL-1 5-lipoxygenase	[PMID: 3681891]
RBL-1	IC₅₀	0.4 μM Compound: NDGA	In vitro inhibitory activity against RBL-1 5-LO In vitro inhibitory activity against RBL-1 5-LO	[PMID: 3820229]
RBL-1	IC₅₀	1.0 x 10^-7 M Compound: NDGA	In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determined In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determined	[PMID: 8254620]
RBL-1	IC₅₀	0.12 μM Compound: NDGA	Inhibition of 5-lipoxygenase by measuring 5-HETE levels in RBL-1 cell-free supernatant Inhibition of 5-lipoxygenase by measuring 5-HETE levels in RBL-1 cell-free supernatant	[PMID: 8568814]
RBL-1	IC₅₀	10 nM Compound: NDGA	Inhibition of 5-lipoxygenase from rat basophilic leukemia(RBL-1) cells Inhibition of 5-lipoxygenase from rat basophilic leukemia(RBL-1) cells	10.1016/S0960-894X(01)80140-2
SGC-7901	IC₅₀	>60 μM Compound: NDGA	Antiproliferative activity against human SGC7901 cells after 72 hrs by MTT assay Antiproliferative activity against human SGC7901 cells after 72 hrs by MTT assay	[PMID: 27829519]

In Vitro

The natural dicatechol Nordihydroguaiaretic acid (NDGA) is a selective 5LOX inhibitor from the creosote plant (Larrea tridentata: Zygophyllaceae). The 5LOX-inhibiting natural dicatechol Nordihydroguaiaretic acid is a very effective, non-toxic antagonist of TNFα-stimulated microglial activation. Nordihydroguaiaretic acid is approximately six times more potent than Minocycline in vitro, with an IC₅₀ value of 8±3 μM and no toxicity at 100 μM. Significant NO₂^- suppression is observed at 800 nM Nordihydroguaiaretic acid. Similar efficacy is observed for natural and synthetic Nordihydroguaiaretic acid, as well as for the acetyl ester of Nordihydroguaiaretic acid. Nordihydroguaiaretic acid also suppresses TNFα-stimulated PGE₂ production by EOC-20 cells with an IC₅₀ of 841 nM^[1].To test the proliferation effect of prostaglandin E1 and Nordihydroguaiaretic acid (NDGA) on cancer cell lines, HepG2 cell lines are treated with various doses of the two compounds and the positive compounds 8-anilino-1-naphtalene sulfonate (ANS), respectively, for 24 h and cell viability is examined by the MTT assay. ANS displays a dose-dependent inhibition (0, 10, 30, 50, 80, 100, 120, and 150 μM) with the estimated IC₅₀ being 25.888 μM. The tested IC₅₀ of prostaglandin E1 is 41.223 μM and Nordihydroguaiaretic acid is 45.646 μM, respectively, at different concentrations of 0, 30, 60, 80, 100, 120, and 140 μM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Compared with the control ob/ob chow diet group, there is a significant reduction of body weight starting from 9 wk treatment in the high-dose Nordihydroguaiaretic acid (NDGA) diet group, and from 12 wk in the low-dose group. Nordihydroguaiaretic acid treatment results in higher body (rectal) temperatures of ob/ob mice, especially with the high dose of Nordihydroguaiaretic acid^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 500-38-9
Appearance Solid
Molecular Weight 302.36
Formula C₁₈H₂₂O₄
Color White to yellow
SMILES

CC(CC1=CC=C(O)C(O)=C1)C(C)CC2=CC=C(O)C(O)=C2
Synonyms

NDGA
Structure Classification
- Phenylpropanoids
- Lignans
- Phenols
- Polyphenols
Initial Source
- Plants
- other families
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Store at room temperature 3 years

In solvent	-80°C	2 years
	-20°C	1 year

Publications (8)

All Cell Proliferation/Viability AssayELISACell Imaging/StainingIn Vivo Efficacy Study

Sort by:

Journal Impact Factor

J Adv Res

Heme oxygenase 1 (HO-1) is a drug target for reversing cisplatin resistance in non-small cell lung cancer. [Abstract]

2025 May 17:S2090-1232(25)00347-9. PMID: 40389113

Nordihydroguaiaretic acid purchased from MedChemExpress. Usage Cited in: J Adv Res. 2025 May 17:S2090-1232(25)00347-9. [Abstract]

The survival rates and IC₅₀ of A549-R when treated with Nordihydroguaiaretic acid (NDGA) individually.
Adv Healthc Mater

Polytonic drug release via multi- hierarchical microstructures enabled by nano-metamaterials. [Abstract]

2023 Jun;12(15):e2202826. PMID: 36871175
Neuropharmacology

Antibiotic-mediated gut microbiota depletion partially attenuates methamphetamine-induced reward and linoleic acid metabolic disturbance. [Abstract]

2026 May 13:296:111022. PMID: 42134644
PLoS Negl Trop Dis

Identification of anti-flaviviral drugs with mosquitocidal and anti-Zika virus activity in Aedes aegypti. [Abstract]

2019 Aug 20;13(8):e0007681. PMID: 31430351
Vet Microbiol

The Chinese medicine monomer Schisandrin C inhibits PRRSV infection by regulating the OGT-PI3K/AKT/mTOR signaling pathway. [Abstract]

2026 May:316:110992. PMID: 41865607
Vet Microbiol

Identification and evaluation of Nordihydroguaiaretic acid (NDGA) as an active traditional Chinese medicine compound inhibiting the 3C-like protease of feline infectious peritonitis virus. [Abstract]

2025 Sep 15:310:110730. PMID: 40976146

Nordihydroguaiaretic acid purchased from MedChemExpress. Usage Cited in: Vet Microbiol. 2025 Sep 15:310:110730. [Abstract]

Cytotoxicity assessment of three candidate compounds—Nordihydroguaiaretic acid (NDGA, 3.125-50 μM) (blue), 3E (green), and GC376 (yellow)—in CRFK cells. Cytotoxicity was determined using a CCK-8 assay after 24 hours of incubation.

Nordihydroguaiaretic acid purchased from MedChemExpress. Usage Cited in: Vet Microbiol. 2025 Sep 15:310:110730. [Abstract]

Fluorescence imaging of CRFK cells infected with FCoV-II GFP strain following treatment with different concentrations of and Nordihydroguaiaretic acid (NDGA, 2.5-10 μM; 24 h). A reduction in GFP fluorescence intensity indicates antiviral activity.

Nordihydroguaiaretic acid purchased from MedChemExpress. Usage Cited in: Vet Microbiol. 2025 Sep 15:310:110730. [Abstract]

Nordihydroguaiaretic acid (NDGA, 6.14 mg/kg, p.o., once daily) alleviated clinical symptoms in FCoV-II-induced feline infectious peritonitis (FIP) model cats, as evidenced by a reduced rate of weight loss and delayed onset of fever.
Biochem Biophys Res Commun

Effects of intracellular iron overload on cell death and identification of potent cell death inhibitors. [Abstract]

2018 Sep 3;503(1):297-303. PMID: 29890135
Biomed Pharmacother

Cepharanthine attenuates cerebral ischemia/reperfusion injury by reducing NLRP3 inflammasome-induced inflammation and oxidative stress via inhibiting 12/15-LOX signaling. [Abstract]

2020 Jul:127:110151. PMID: 32559840

Nordihydroguaiaretic acid purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2020 Jul:127:110151. [Abstract]

CEP suppresses OGD/R-induced oxidative stress in BV-2 cells. After treatment with different concentrations of CEP or 10 μM Nordihydroguaiaretic acid (NDGA) (30 min), BV-2 cells were subjected to OGD/R to mimic I/R injury in vitro. After induction, cells were harvested for ELISA analysis of 12-HETE and 15-HETE. NDGA (LOX inhibitor) served as positive controls.

Solvent & Solubility

In Vitro:

DMSO : 233.33 mg/mL (771.70 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.3073 mL

16.5366 mL

33.0732 mL

5 mM

0.6615 mL

3.3073 mL

6.6146 mL

10 mM

0.3307 mL

1.6537 mL

3.3073 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.08 mg/mL (6.88 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.08 mg/mL (6.88 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.08 mg/mL (6.88 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Protocol

Cell Assay^[2]

MTT assay is used to measure cell growth-inhibitory activity of the selected most promising compounds in HepG2 cell lines. Cells are cultured in 96-well culture plate at 1×10⁴ cells/well. After 24 h cultured at 37 °C in the atmosphere of 5% CO₂, cells are adhered and treated with different concentrations of the targeted compounds (e.g., Nordihydroguaiaretic acid, 0, 30, 60, 80, 100, 120, and 140 μM) and incubated for 24 h. Then, the supernatants are discarded and MTT (0.5 mg/mL) is added to each well and incubated at 37°C in 5% CO₂ for an additional 4 h. Following, the MTT is removed and 150 μL of formazan in DMSO is added to terminate response and then plates are set to the table shaker for 5 min at low speed. Cell proliferation is evaluated by measuring the absorbance at 570 nm using ELISA Plate Reader. The IC₅₀ values are calculated by SPSS statistics 17.0^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Administration^[3]

Mice^[3]
Seven-week-old male control C57BL/6J mice, male leptin-deficient (ob/ob) mice, and male Pparα-deficient mutant mice (B6.129S4-Pparatm1Gonz/J) are used. These mice are fed a standard chow diet for 1 wk to allow them to acclimatize to a controlled new environment (25±2°C, 55±5% relative humidity with a 12-h light-dark cycle). Subsequently, one group of ob/ob mice is switched to a chow diet supplemented with either low- (0.83 g/kg chow diet) or high-dose (2.5 g/kg chow diet) Nordihydroguaiaretic acid and maintained on this diet for 16 wk. The other groups of ob/ob mice and control mice continue to be fed a normal chow diet for 16 wk. In another set of studies, C57BL/6J mice and Pparα-deficient mutant mice are fed either a high-fat diet (~60% of total calories come from fat), or the same high-fat diet supplemented with a high dose of Nordihydroguaiaretic acid (2.5 g/kg diet). Food intake and body weights are measured once a week throughout the experiment.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (290 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. West M, et al. The arachidonic acid 5-lipoxygenase inhibitor Nordihydroguaiaretic acid inhibits tumor necrosis factor alpha activation of microglia and extends survival of G93A-SOD1 transgenic mice. J Neurochem. 2004 Oct;91(1):133-43. [Content Brief]

[2]. Lu F, et al. Virtual Screening for Potential Allosteric Inhibitors of Cyclin-Dependent Kinase 2 from Traditional Chinese Medicine. Molecules. 2016 Sep 21;21(9). pii: E1259. [Content Brief]

[3]. Zhang H, et al. Nordihydroguaiaretic acid improves metabolic dysregulation and aberrant hepatic lipid metabolism in mice by both PPARα-dependent and -independent pathways. Am J Physiol Gastrointest Liver Physiol. 2013 Jan 1;304(1):G72-86. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.3073 mL	16.5366 mL	33.0732 mL	82.6829 mL
	5 mM	0.6615 mL	3.3073 mL	6.6146 mL	16.5366 mL
	10 mM	0.3307 mL	1.6537 mL	3.3073 mL	8.2683 mL
	15 mM	0.2205 mL	1.1024 mL	2.2049 mL	5.5122 mL
	20 mM	0.1654 mL	0.8268 mL	1.6537 mL	4.1341 mL
	25 mM	0.1323 mL	0.6615 mL	1.3229 mL	3.3073 mL
	30 mM	0.1102 mL	0.5512 mL	1.1024 mL	2.7561 mL
	40 mM	0.0827 mL	0.4134 mL	0.8268 mL	2.0671 mL
	50 mM	0.0661 mL	0.3307 mL	0.6615 mL	1.6537 mL
	60 mM	0.0551 mL	0.2756 mL	0.5512 mL	1.3780 mL
	80 mM	0.0413 mL	0.2067 mL	0.4134 mL	1.0335 mL
	100 mM	0.0331 mL	0.1654 mL	0.3307 mL	0.8268 mL

Bioz

Keywords

Nordihydroguaiaretic acid

8 Cited Publications

100 mg Get Quote

Subscribe to the

MedChemExpress

Newsletter

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Product Name:
CAS No.:
Species:
Purity:
Quantity:

Nordihydroguaiaretic acid

Rapamycin

Baicalein

Zileuton

Sesamin

(-)-Epicatechin

(-)-Epigallocatechin Gallate

Onvoloxastat

Spermidine

Fisetin

Metformin

Dimethyl sulfoxide, meets analytical specification of Ch.P.

Curcumin

Publications Citing Use of MedChemExpress (MCE) Nordihydroguaiaretic acid

All Lipoxygenase Isoforms

Biological Activity

Chemical Information

Publications (8)

Solvent & Solubility

Protocol

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Bioz

Nordihydroguaiaretic acid

Rapamycin

Baicalein

Zileuton

Sesamin

(-)-Epicatechin

(-)-Epigallocatechin Gallate

Onvoloxastat

Spermidine

Fisetin

Metformin

Dimethyl sulfoxide, meets analytical specification of Ch.P.

Curcumin

Publications Citing Use of MedChemExpress (MCE) Nordihydroguaiaretic acid

All Lipoxygenase Isoforms

Biological Activity

Chemical Information

Publications (8)

Solvent & Solubility

Protocol

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Nordihydroguaiaretic acid Related Classifications

HY-N0198 Related Classifications

Bioz