15-LOX
15-Lipoxygenase-1 (15-LOX-1, ALOX15) is a non-heme iron-containing dioxygenase that catalyzes the oxygenation of polyunsaturated fatty acids and contributes to the generation of bioactive lipid mediators involved in lipid metabolism, inflammation, and cellular homeostasis[1]. Mechanistically, 15-LOX-1 participates in the lipoxygenase pathway by converting arachidonic acid and other polyunsaturated fatty acids into oxygenated lipid products that regulate inflammatory signaling and membrane remodeling processes[1]. Through these activities, ALOX15 has been implicated in multiple physiological and pathological settings, and its functions have been investigated extensively in cellular systems and animal disease models associated with inflammatory, hyperproliferative, and neurodegenerative conditions[1]. Compared with the closely related isoform ALOX15B (15-LOX-2), which primarily catalyzes oxygenation at carbon 15 and has limited capacity to generate alternative products, 15-LOX-1 exhibits broader substrate utilization and distinct reaction specificity, highlighting important functional differences among lipoxygenase isoforms[2]. This distinction is particularly relevant when interpreting lipid mediator profiles and designing mechanistic studies targeting specific LOX pathways[2]. For experimental applications, selective pharmacological inhibition of 15-LOX-1 has emerged as a valuable strategy for dissecting enzyme-dependent signaling networks; a potent 15-LOX-1 inhibitor was reported to protect macrophages from regulated cell death, supporting the use of 15-LOX-1 inhibitors as research tools for investigating inflammatory mechanisms and lipid-peroxidation-driven cellular responses[3].
References:
- [1]. Ivanov I, et al. Structural and functional biology of arachidonic acid 15-lipoxygenase-1 (ALOX15). Gene. 2015 Nov 15;573(1):1-32. [Content Brief]
- [2]. Benatzy Y, et al. Arachidonate 15-lipoxygenase type B: Regulation, function, and its role in pathophysiology. Front Pharmacol. 2022 Nov 9;13:1042420. [Content Brief]
- [3]. Guo H, et al. Novel 15-Lipoxygenase-1 Inhibitor Protects Macrophages from Lipopolysaccharide-Induced Cytotoxicity. J Med Chem. 2019 May 9;62(9):4624-4637. [Content Brief]
All Product Categories
-
15-LOX Related Products (17)
Related Products (17)
- 1
-
15-LOX-1 inhibitor 1
0 Images15-LOX-1 inhibitor 1 is a potent inhibitor of 15-LOX-1 (15-lipoxygenase-1) with an IC50 value of 0.19 μM. 15-LOX-1 inhibitor 1 protects macrophages from lipopolysaccharide-induced cytotoxicity. 15-LOX-1 inhibitor 1 inhibits NO formation and lipid peroxidation.
-
Tenidap
0 ImagesSynonyms: CP-66248Tenidap (CP-66248) is an orally active dual inhibitor of 5-LOX and COX with anti-inflammatory and immunomodulatory properties. Tenidap downregulates the expression of IL-1 receptors in chondrocytes, reduces the release of pro-inflammatory cytokines such as IL-1, IL-6 and TNF-α, and inhibits MMP production and cartilage degradation. Tenidap also blocks bone resorption and leukocyte adhesion to vascular endothelium, interferes with ion and pH changes associated with mouse sperm capacitation, and selectively enhances the activity of hKir2.3 channels (EC50=1.3 μM). Tenidap is applicable to research related to rheumatoid arthritis.
-
Methyl orsellinate
0 ImagesMethyl orsellinate acts as an antiviral agent and insecticide. Methyl orsellinate exhibits enzyme inhibitory activity, with an IC50 of 59.6 µM against porcine leukocyte 5-lipoxygenase (5-LOX); it inhibits soybean 15-lipoxygenase (15-LOX), and shows weak inhibitory activity against acetylcholinesterase (AChE) and glutathione S-transferase (GST). Methyl orsellinate displays contact toxicity against adult Drosophila suzukii. Methyl orsellinate shows anti-HSV-1 activity. Methyl orsellinate can be used in studies related to *Drosophila suzukii* infestation and HSV-1 infection.
-
Damnacanthol
0 ImagesDamnacanthol is a natural product that can be isolated from Damnacanthus major. Damnacanthol has anti-15-lipoxygenase activity and can inhibit nitric oxide production in LPS-activated macrophages RAW 264.7 cells.
-
CNB-001
0 ImagesCat. No.: HY-158204CAS No.: 1019110-87-2CNB-001 is a potent and orally active 5-lipoxygenase (5-LOX) inhibitor. CNB-001 can decreases 5-LOX expression and increase proteasome activity. CNB-001 can inhibit accumulation of soluble Amyloid-β and ubiquitinated aggregated proteins. CNB-001 can inhibit apoptosis, ROS production and stabilize mitochondrial membrane potential. CNB-001 can reduce insulin resistance and increase glucose uptake. CNB-001 also exhibits anti-ischemic, anti-inflammatory effects. CNB-001 can be used for the researches of inflammation, neurological and metabolic disease, such as Alzheimer's disease, stroke and diabetes.
-
COX/5-LO-IN-2
0 ImagesCat. No.: HY-181061COX/5-LO-IN-2 is a COX2, EGFR, COX1, 5-LOX, BRAF and FAK inhibitor with IC50 of 1.22 μM, 2.5 μM, 2.95 μM, 4.65 μM, 7.4 μM, 12.2 μM, respectively. COX/5-LO-IN-2 induces cell growth arrest at G2/M phase. COX/5-LO-IN-2 triggers apoptotic activity by up-regulating proapoptotic proteins p53, Bax, and caspase-7 and down-regulating anti-apoptotic protein Bcl-2. COX/5-LO-IN-2 can be used for the research of breast cancer.
-
BLX-3887
0 ImagesBLX-3887 is a selective 15-lipoxygenase type 1 (15-LO-1) inhibitor with an IC50 of 32 nM. BLX-3887 can be utilized in research related to the 15-LO pathways.
-
Caffeoylcalleryanin
0 ImagesCat. No.: HY-N12987CAS No.: 20300-49-6Caffeoylcalleryanin is a potent 15-lipoxygenase inhibitor with an IC50 value of 1.59 µM. Caffeoylcalleryanin shows no cytotoxic.
-
MLS000099089
0 ImagesCat. No.: HY-175970CAS No.: 423735-70-0
-
15-LOX-IN-2
0 ImagesCat. No.: HY-17311515-LOX-IN-2 (Compound 2a) is an orally active COX-2/15-LOX inhibitor and a partial agonist of PPARγ. 15-LOX-IN-2 has anti-inflammatory activity and inhibits the levels of 20-HETE, IL-1β and TNF-α in RAW 264.7 cells treated with LPS (HY-D1056). In addition, 15-LOX-IN-2 has significant glucose uptake capacity in the absence of insulin. 15-LOX-IN-2 can be used for the research of metabolic diseases.
-
COX-2/15-LOX-IN-7
0 ImagesCat. No.: HY-179021CAS No.: 1860810-23-6COX-2/15-LOX-IN-7 is a potent, selective and orally active dual inhibitor of COX-2 and 15-LOX with IC50 values of 0.022 and 1.19 μM. COX-2/15-LOX-IN-7 also inhibits COX-1 with an IC50 value of 28.081μM. COX-2/15-LOX-IN-7 has low cytotoxicity against human colorectal cancer HT-29 and HCT116 cell lines (IC50 >100 μM for both). COX-2/15-LOX-IN-7 exhibits non-ulcerogenic performance. COX-2/15-LOX-IN-7 can be used for the research of cancer.
-
BLX-2477
0 ImagesCat. No.: HY-117317CAS No.: 1080008-87-2BLX-2477 is a potent and selective 15-lipoxygenase-1 (15-LOX-1) inhibitor with an IC50 value of 99 nM. BLX-2477 can inhibit the generation of inflammatory lipid mediators such as 15-hydroxy-eicosatetraenoic acid (15-HETE). BLX-2477 can be used for the research of inflammation and immunology.
-
Asperenone
0 ImagesCat. No.: HY-N15453CAS No.: 18810-05-4Asperenone is an inhibitor of 15-lipoxygenase (15-LOX) with an IC50 value of 0.3 mM. It is also an inhibitor of platelet aggregation, with an IC50 value of 0.23 mM. Additionally, Asperenone has antifungal activity and can inhibit the growth of pathogenic fungi Ophiostoma crassivaginatum and O. piliferum. Asperenone can be used in the research of cardiovascular diseases and anti-infection fields.
- 1
