15-LOX-IN-2
15-LOX-IN-2 (Compound 2a) is an orally active COX-2/15-LOX inhibitor and a partial agonist of PPARγ. 15-LOX-IN-2 has anti-inflammatory activity and inhibits the levels of 20-HETE, IL-1β and TNF-α in RAW 264.7 cells treated with LPS (HY-D1056). In addition, 15-LOX-IN-2 has significant glucose uptake capacity in the absence of insulin. 15-LOX-IN-2 can be used for the research of metabolic diseases.
For research use only. We do not sell to patients.
- Formula: C17H16N2O2S
- Molecular Weight:312.39
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
COX-2 0.190 μM (IC50) |
IL-1β |
15-LOX 5.87 μM (IC50) |
COX-1 7.510 μM (IC50) |
PPARγ |
Chemical Information
-
Molecular Weight 312.39
-
Formula C17H16N2O2S
-
SMILES
O=C1N=C(N2CCCC2)S/C1=C\C3=CC=C(OCC#C)C=C3
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz