15-LOX-IN-2
15-LOX-IN-2 (Compound 2a) is an orally active COX-2/15-LOX inhibitor and a partial agonist of PPARγ. 15-LOX-IN-2 has anti-inflammatory activity and inhibits the levels of 20-HETE, IL-1β and TNF-α in RAW 264.7 cells treated with LPS (HY-D1056). In addition, 15-LOX-IN-2 has significant glucose uptake capacity in the absence of insulin. 15-LOX-IN-2 can be used for the research of metabolic diseases.
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- Formule: C17H16N2O2S
- Masse moléculaire:312.39
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
[1]|
COX-2 0.190 μM (IC50) |
IL-1β |
15-LOX 5.87 μM (IC50) |
COX-1 7.510 μM (IC50) |
PPARγ |
Chemical Information
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Masse moléculaire 312.39
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Formule C17H16N2O2S
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SMILES
O=C1N=C(N2CCCC2)S/C1=C\C3=CC=C(OCC#C)C=C3
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
15-LOX-IN-2 Related Classifications
HY-173115 Related Classifications
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