1. Isotope-Labeled Compounds
  2. Isotope-Labeled Synthetic Intermediates

Isotope-Labeled Synthetic Intermediates

These Stable Isotope-Labeled Synthetic Intermediates play an important role in the synthesis of drugs and drug discovery. MedChemExpress ( MCE ) offers a broad range of Stable Isotope-Labeled Synthetic Intermediates containing different stable isotope atoms, such as deuterium ( 2H, D ), carbon-13 ( 13C ), nitrogen-15 ( 15N ), etc. According to our customers’ requirements, we could provide customized services of different Stable Isotope-Labeled synthetic intermediates from milligrams to kilograms.

Isotope-Labeled Synthetic Intermediates (325):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-I1124
    L-Valine-d8 35045-72-8 ≥99.0%
    L-Valine-d8 is a deuterated form of L-Valine. L-Valine-d8 can be used in the labelled synthesis of L-valineamide-d8 intermediate[1]. L-Valine is one of 20 proteinogenic amino acids. L-Valine is an essential amino acid[2].
  • HY-18569S
    3-Indoleacetic acid-d5 76937-78-5 99.84%
    3-Indoleacetic acid-d5 is the deuterium labeled 3-Indoleacetic acid. 3-Indoleacetic acid-d5 can be used as internal standard for assay of IAA releases by alkaline hydrolysis of ester and amide conjugates[1].
    3-Indoleacetic acid-d<sub>5</sub>
  • HY-W015967S
    Glycolic acid-d2 75502-10-2 ≥98.0%
    Glycolic acid-d2 is the deuterium labeled Glycolic acid. Glycolic acid is an inhibitor of tyrosinase, suppressing melanin formation and lead to a lightening of skin colour.
    Glycolic acid-d<sub>2</sub>
  • HY-B0649S1
    Propofol-d18 1189467-93-3
    Propofol-d18 is the deuterium labeled Propofol. Propofol potently and directly activates GABAA receptor and inhibits glutamate receptor mediated excitatory synaptic transmission[1].
  • HY-B2130S1
    Uric acid-15N2 62948-75-8 ≥99.0%
    Uric acid-15N2 is the 15N labeled Uric acid[1]. Uric acid, scavenger of oxygen radical, is a very important antioxidant that help maintains the stability of blood pressure and antioxidant stress. Uric acid can remove reactive oxygen species (ROS) such as singlet oxygen and peroxynitrite, inhibiting lipid peroxidation[2][3].
    Uric acid-<sup>15</sup>N<sub>2</sub>
  • HY-Y0262S1
    Oxalic acid-13C2 62654-02-8 ≥99.0%
    Oxalic acid-13C2is the deuterium labeledOxalic acid, 99%(HY-Y0262). Oxalic Acid is a strong dicarboxylic acid occurring in many plants and vegetables and can be used as an analytical reagent and general reducing agent.
    Oxalic acid-<sup>13</sup>C<sub>2</sub>
  • HY-19528S
    SAH-d4 ≥99.0%
    SAH-d4 is the deuterium labeled SAH. SAH (S-Adenosylhomocysteine) is an amino acid derivative and a modulartor in several metabolic pathways. It is an intermediate in the synthesis of cysteine and adenosine[1]. SAH is an inhibitor for METTL3-METTL14 heterodimer complex (METTL3-14) with an IC50 of 0.9 µM[2].
  • HY-W015913S
    Sodium 2-oxopropanoate-13C3 142014-11-7 ≥98.0%
    Sodium 2-oxopropanoate-13C3 is the 13C-labeled Sodium 2-oxopropanoate. Sodium 2-oxopropanoate (Sodium pyruvate), a three-carbon metabolite of Glucose, is a compound produced in the glycolytic pathway. Sodium 2-oxopropanoate is a free radical scavenger that can scavenge ROS[1][2].
    Sodium 2-oxopropanoate-<sup>13</sup>C<sub>3</sub>
  • HY-Y0781S
    Pyruvic acid-13C sodium 87976-70-3 ≥98.0%
    Pyruvic acid-13C (sodium) is the 13C-labeled Pyruvic acid. Pyruvic acid is an intermediate metabolite in the metabolism of carbohydrates, proteins, and fats.
    Pyruvic acid-<sup>13</sup>C sodium
  • HY-N0666S
    L-Aspartic acid-13C 81201-97-0 ≥98.0%
    L-Aspartic acid-13C is a 13C labeled L-Aspartic acid. L-Aspartic acid is is an amino acid, shown to be a suitable proagent for colon-specific agent deliverly[1][2].
    L-Aspartic acid-<sup>13</sup>C
  • HY-N0337S
    Eugenol-d3 1335401-17-6 99.86%
    Eugenol-d3 is the deuterium labeled Eugenol. Eugenol is an essential oil found in cloves with antibacterial, anthelmintic and antioxidant activity. Eugenol is shown to inhibit lipid peroxidation.
  • HY-18569S2
    3-Indoleacetic acid-2,2-d2 24420-86-8 98.06%
    3-Indoleacetic acid-2,2-d2 is the deuterium labeled 3-Indoleacetic acid. 3-Indoleacetic acid (Indole-3-acetic acid) is the most common natural plant growth hormone of the auxin class. It can be added to cell culture medium to induce plant cell elongation and division.
    3-Indoleacetic acid-2,2-d<sub>2</sub>
  • HY-B0167S
    Salicylic acid-d6 285979-87-5 99.83%
    Salicylic acid-d6 is a deuterium labeled Salicylic acid. Salicylic acid inhibits cyclo-oxygenase-2 (COX-2) activity independently of transcription factor (NF-κB) activation[1].
    Salicylic acid-d<sub>6</sub>
  • HY-W007355S
    Skatole-d3 111399-60-1 ≥98.0%
    Skatole-d3 is the deuterium labeled Skatole. Skatole is produced by intestinal bacteria, regulates intestinal epithelial cellular functions through activating aryl hydrocarbon receptors and p38[1].
  • HY-144140S
    4-Nitroso hydrochlorothiazide-13C,15N2,d2 99.34%
    4-Nitroso hydrochlorothiazide-13C,15N2,d2 is the deuterium, 13C-, and 15-labeled 4-Nitroso hydrochlorothiazide[1].
    4-Nitroso hydrochlorothiazide-<sup>13</sup>C,<sup>15</sup>N<sub>2</sub>,d<sub>2</sub>
  • HY-W009973S
    4-Anilino-4-oxobutanoic acid-d5 840529-98-8 ≥99.0%
    4-Anilino-4-oxobutanoic acid-d5 is the deuterium labeled 4-Anilino-4-oxobutanoic acid[1].
    4-Anilino-4-oxobutanoic acid-d<sub>5</sub>
  • HY-66008S
    N-Acetyl mesalazine-d3 93968-79-7 ≥98.0%
    N-Acetyl mesalazine-d3 is the deuterium labeled N-Acetyl mesalazine[1].
    N-Acetyl mesalazine-d<sub>3</sub>
  • HY-113259S
    7α-Hydroxy-4-cholesten-3-one-d7 2260669-17-6 ≥98.0%
    7α-Hydroxy-4-cholesten-3-one-d7 is the deuterium labeled 7α-Hydroxy-4-cholesten-3-one. 7α-Hydroxy-4-cholesten-3-one is an intermediate in synthesis of bile acids from cholesterol. 7α-Hydroxy-4-cholesten-3-one is a pregnane X receptor (PXR) agonist. 7α-Hydroxy-cholest-4-en-3-one is a biomarker for bile acid loss, irritable bowel syndrome, and other diseases associated with defective bile acid biosynthesis. 7α-Hydroxy-cholest-4-en-3-one is the physiological substrate for CYP8B1[1][2].
  • HY-15037S1
    Diclofenac-d4 sodium 154523-54-3 ≥99.0%
    Diclofenac-d4 (sodium) is the deuterium labeled Diclofenac sodium. Diclofenac Sodium (GP 45840) is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells[1], and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively[2]. Diclofenac Sodium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade[3].
    Diclofenac-d<sub>4</sub> sodium
  • HY-34740S
    Ethylmalonic acid-d3 70907-93-6 ≥99.0%
    Ethylmalonic acid-d3 is the deuterium labeled Ethylmalonic acid. Ethylmalonic acid is non-carcinogenic potentially toxic and associated with anorexia nervosa and malonyl-CoA decarboxylase deficiency.
    Ethylmalonic acid-d<sub>3</sub>