1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. Tyrosinase

Tyrosinase

Tyrosinase is an oxidase that is the rate-limiting enzyme for controlling the production of melanin. The enzyme is mainly involved in two distinct reactions of melanin synthesis. Tyrosinase is a copper-containing enzyme present in plant and animal tissues that catalyzes the production of melanin and other pigments from tyrosine by oxidation, as in the blackening of a peeled or sliced potato exposed to air. It is found inside melanosomes which are synthesised in the skin melanocytes. In humans, the tyrosinase enzyme is encoded by the TYR gene. Tyrosinase is one of the key enzymes in mammalian melanin synthesis.

Tyrosinase Related Products (26):

Cat. No. Product Name Effect Purity
  • HY-N0136
    Taxifolin Inhibitor 99.97%
    Taxifolin ((+)-Dihydroquercetin) exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC50 value of 193.3 μM.
  • HY-W013636
    2-Ketoglutaric acid Inhibitor
    2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM).
  • HY-N1430
    Oxyresveratrol Inhibitor 99.91%
    Oxyresveratrol is neuroprotective and inhibits the apoptotic cell death in transient cerebral ischemia.
  • HY-15811
    XMD8-87 Inhibitor 98.29%
    XMD8-87 is a potent TNK2 inhibitor with IC50 values of 38 and 113 nM for the D163E and R806Q mutations, respectively.
  • HY-B0986
    Hexylresorcinol Inhibitor >98.0%
    Hexylresorcinol is an organic compound with local anaesthetic, antiseptic and anthelmintic properties, is a potent inhibitor of mushroom tyrosinase, causing 90% loss of activity at 100 μM.
  • HY-N2278
    Kushenol A Inhibitor 99.84%
    Kushenol A is isolated from the root of Sophora flavescent, a non-competitive tyrosinase inhibitor with IC50 and Ki values of 1.1 μM and 0.4 μM, respectively. Kushenol A is a flavonoid antioxidant, has inhibitory effects on alpha-glucosidase and beta-amylase. Kushenol A is confirmed as potential inhibitors of enzymes targeted by cosmetics for skin whitening and aging.
  • HY-N0616
    Trifolirhizin Inhibitor >99.0%
    Trifolirhizin is a pterocarpan flavonoid isolated from the roots of Sophora flavescens. Trifolirhizin possesses potent tyrosinase inhibitory activity with an IC50 of 506 μM. Trifolirhizin exhibits potential anti-inflammatory and anticancer activities.
  • HY-101445A
    (R)-Trolox Inhibitor 99.94%
    (R)-Trolox is a water soluble vitamin E analogue and a competitive tyrosinase inhibitor with a Ki value of 0.83 mM and a ID50 value of 1.88 mM. The (R)-Trolox has stronger tyrosinase affinity than the (S) enantiomer (Ki value of 0.61 mM).
  • HY-N0192
    Arbutin Inhibitor >98.0%
    Arbutin (β-Arbutin) is a competitive inhibitor of tyrosinase in melanocytes, with Kiapp values of 1.42 mM for monophenolase; 0.9 mM for diphenolase. Arbutin is also used as depigmenting agents. Arbutin is a natural polyphenol isolated from the bearberry plant Arctostaphylos uvaursi, possesses with anti-oxidant, anti-inflammatory and anti-tumor properties.
  • HY-101243
    XMD16-5 Inhibitor 98.73%
    XMD16-5 is a potent TNK2 inhibitor with IC50 values of 16 and 77 nM for the D163E and R806Q mutations, respectively.
  • HY-B1461
    Deoxyarbutin Inhibitor >98.0%
    Deoxyarbutin is a new effective lighten ingredient, can effectively inhibit tyrosinase activity and melanin synthesis to get significant and lasting lightening effect.
  • HY-N0619
    Mulberroside A Inhibitor 99.53%
    Mulberroside A is one of the main bioactive constituent in mulberry (Morus alba L.). Mulberroside A decreases the expressions of TNF-α, IL-1β, and IL-6 and inhibits the activation of NALP3, caspase-1, and NF-κB and the phosphorylation of ERK, JNK, and p38, exhibiting anti-inflammatory antiapoptotic effects. Mulberroside A shows inhibitory activity against mushroom tyrosinase with an IC50 of 53.6 μM.
  • HY-N0445
    2-Hydroxy-4-methoxybenzaldehyde Inhibitor 99.90%
    2-Hydroxy-4-methoxybenzaldehyde, a chemical compound and an isomer of Vanillin, could be used to synthesis Urolithin M7. 2-hydroxy-4-methoxybenzaldehyde is a potent tyrosinase inhibitor from three East African medicinal plants, Mondia whitei, Rhus vulgaris Meikle, and Sclerocarya caffra Sond.
  • HY-W015967
    Glycolic acid Inhibitor
    Glycolic acid is an inhibitor of tyrosinase, suppressing melanin formation and lead to a lightening of skin colour.
  • HY-126052
    Gnetol Inhibitor
    Gnetol is a phenolic compound isolated from the root of Gnetum ula Brongn. Gnetol potently inhibits COX-1 (IC50 of 0.78 μM) and HDAC. Gnetol is a potent tyrosinase inhibitor with an IC50 of 4.5 μM for murine tyrosinase and suppresses melanin biosynthesis. Gnetol has antioxidant, antiproliferative, anticancer and hepatoprotective activity. Gnetol also possesses concentration-dependent α-Amylase, α-glucosidase, and adipogenesis activities.
  • HY-N1750
    3-(2,4-Dihydroxyphenyl)propanoic acid Inhibitor
    3-(2,4-Dihydroxyphenyl)propanoic acid (DPPacid) is a potent and competitive tyrosinase inhibitor, inhibits L-Tyrosine and DL-DOPA with an IC50 and a Ki of 3.02 μM and 11.5 μM, respectively.
  • HY-W015616
    Benzylacetone Inhibitor
    Benzylacetone is an aromatic compound from agarwood. Benzylacetone exhibits potent and reversible antityrosinase (mushroom) activity, with IC50s of 2.8 mM and 0.6 mM for monophenolase and diphenolase, respectively. Benzylacetone has appetite-enhancing and locomotor-reducing effects.
  • HY-N2204
    Swertiajaponin Inhibitor
    Swertiajaponin is a tyrosinase inhibitor, forms multiple hydrogen bonds and hydrophobic interactions with the binding pocket of tyrosinase, with an IC50 of 43.47 μM. Swertiajaponin also inhibits oxidative stress-mediated MAPK/MITF signaling, leading to decrease in tyrosinase protein level. Swertiajaponin suppresses melanin accumulation and exhibits strong anti-oxidative activity.
  • HY-W013636B
    Calcium 2-oxoglutarate Inhibitor
    2-Ketoglutaric acid calcium (Alpha-Ketoglutaric acid calcium) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid calcium also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid calcium is a reversible inhibitor of tyrosinase (IC50=15 mM).
  • HY-W013636A
    2-Ketoglutaric acid Sodium Inhibitor
    2-Ketoglutaric acid Sodium (Alpha-Ketoglutaric acid Sodium) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid Sodium also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid Sodium is a reversible inhibitor of tyrosinase (IC50=15 mM).
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