1. Apoptosis
    Immunology/Inflammation
    Metabolic Enzyme/Protease
  2. TNF Receptor
    Interleukin Related
    Tyrosinase

Mulberroside A 

Cat. No.: HY-N0619 Purity: 99.53%
Handling Instructions

Mulberroside A, the major active anti-tyrosinase compound in the root bark extract of Morus alba L.

For research use only. We do not sell to patients.

Mulberroside A Chemical Structure

Mulberroside A Chemical Structure

CAS No. : 102841-42-9

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 143 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
5 mg USD 114 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
10 mg USD 180 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
50 mg USD 540 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Mulberroside A, the major active anti-tyrosinase compound in the root bark extract of Morus alba L. (Moraceae), is widely employed as an active ingredient in whitening cosmetics. IC50 value: 1.29 μmol/L (inhibition of the monophenolase activity); KI value: 0.385 μmol/L (the inhibition constant of the effectors on tyrosinase); KIS value: 0.177 μmol/L (the inhibition constant of the enzyme-substrate complex) [3] Target: In vitro: Mulberroside A decreased the expressions of tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, and IL-6 and inhibited the activation of NALP3, caspase-1, and nuclear factor-κB and the phosphorylation of extracellular signal-regulated protein kinases, the c-Jun N-terminal kinase, and p38 exhibiting anti-inflammatory antiapoptotic effects [1]. Mulberroside A treatment significantly decreased the mRNA and protein expression of P-gp in Caco-2 cells after treatment with Mulberroside A (5–20 μM). PKC and NF-κB might play crucial roles in Mulberroside A-induced suppression of P-gp [2]. In vivo:

References
Molecular Weight

568.52

Formula

C₂₆H₃₂O₁₄

CAS No.

102841-42-9

SMILES

O[[email protected]]([[email protected]@H](O)[[email protected]@H]1O)[[email protected]@H](O[[email protected]@H]1CO)OC2=CC(/C=C/C(C=CC(O[[email protected]@H]([[email protected]@H]([[email protected]@H](O)[[email protected]@H]3O)O)O[[email protected]@H]3CO)=C4)=C4O)=CC(O)=C2

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 40 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
Mulberroside A
Cat. No.:
HY-N0619
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