Sodium carboxymethyl cellulose (Viscosity:800-1200 mPa.s)
(Synonyms: CMC-Na (Viscosity:800-1200 mPa.s))
49 Cited Publications
Customer Review
Based on 49 publication(s) in Google Scholar
Sodium carboxymethyl cellulose (Viscosity:800-1200 mPa.s) is the sodium salt of cellulose arboxymethyl and frequently used as viscous agent, paste and barrier agent.
For research use only. We do not sell to patients.
- Purity: 99.79%
- CAS No.: 9004-32-4
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Storage:
Store at room temperature, keep dry and cool.
In solvent -80°C, 1 year , -20°C, 6 months
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Publications Citing Use of MedChemExpress (MCE) Sodium carboxymethyl cellulose (Viscosity:800-1200 mPa.s)
More- Signal Transduct Target Ther. 2025 Jul 3;10(1):209. [Abstract]
- Bone Res. 2025 Jan 30;13(1):20. [Abstract]
- Acta Pharm Sin B. 2025 Dec;15(12):6461-6477. [Abstract]
- Adv Sci (Weinh). 2025 Oct 2:e01699. [Abstract]
- Cancer Lett. 2025 Feb 8:217544. [Abstract]
- Phytomedicine. 2025 Oct 14:148:157397. [Abstract]
- Phytomedicine. 2025 Sep 15:148:157263. [Abstract]
- Phytomedicine. 2024 Nov 14:136:156227. [Abstract]
- Phytomedicine. 2024 Jun:128:155423. [Abstract]
- Antioxidants (Basel). 2022 Oct 24;11(11):2093. [Abstract]
- Ecotoxicol Environ Saf. 2025 Mar 15:293:118029. [Abstract]
- Biochem Pharmacol. 2026 May:247:117771. [Abstract]
- Biochem Pharmacol. 2024 Jun:224:116240. [Abstract]
- J Ethnopharmacol. 2025 Oct 27:356:120818. [Abstract]
- Mol Ther Oncol. 2024 Aug 8;32(3):200858. [Abstract]
- Inflammopharmacology. 2024 Dec;32(6):3745-3759. [Abstract]
- Drug Des Devel Ther. 2021 Apr 21;15:1641-1652. [Abstract]
- Transplantation. 2025 Apr 9. [Abstract]
- Transplantation. 2022 Nov 1;106(11):2172-2181. [Abstract]
- Mater Adv. 2026 Jan 14.
- Batter Supercaps. 2025 Jun 26.
- Int Immunopharmacol. 2025 Apr 24:153:114401. [Abstract]
- Int Immunopharmacol. 2024 Oct 27;143(Pt 2):113490. [Abstract]
- Int Immunopharmacol. 2024 Jun 18:137:112414. [Abstract]
- Int Immunopharmacol. 2022 Aug:109:108805. [Abstract]
- Int Immunopharmacol. 2022 Jun:107:108681. [Abstract]
- RSC Adv. 2025 Sep 19;15(41):34300-34309. [Abstract]
- Molecules. 2025 Jul 7;30(13):2881. [Abstract]
- Mediators Inflamm. 2023 Feb 20:2023:4436587. [Abstract]
- Sustain Energy Fuels. 2025 Mar 17.
- J Integr Med. 2024 Jan;22(1):83-92. [Abstract]
- Biomedicines. 2026 Mar 19;14(3):714. [Abstract]
- Diabetol Metab Syndr. 2025 Apr 9;17(1):122. [Abstract]
- Food Sci Nutr. 2025 Sep 1;13(9):e70877. [Abstract]
- PLoS Negl Trop Dis. 2022 Oct 7;16(10):e0010848. [Abstract]
- mSphere. 2025 Apr 10:e0006125. [Abstract]
- J Pharmacol Sci. 2025 Jun;158(2):143-153. [Abstract]
- Surgery. 2024 May 28:S0039-6060(24)00230-7. [Abstract]
- Exp Eye Res. 2024 Mar:240:109823. [Abstract]
- PLoS One. 2026 Feb 27;21(2):e0343296. [Abstract]
- Nefrologia. 2025 Sep 1.
- Reprod Sci. 2025 Aug 27. [Abstract]
- Liver Res. 2023 Jun 2;7(2):124-135. [Abstract]
- Clin Exp Nephrol. 2025 Jun 17. [Abstract]
- Res Sq. 2026 Mar 13.
- bioRxiv. 2026 Feb 17.
- Umea University. 2025.
- SSRN. 2024 May 8.
- SSRN. 2024 Mar 13.
Biological Activity
Description
Sodium carboxymethyl cellulose (Viscosity:800-1200 mPa.s) is the sodium salt of cellulose arboxymethyl and frequently used as viscous agent, paste and barrier agent.
In Vivo
Protocal for preparing 0.5% CMC-Na Solution
Measure 0.5g of dry CMC-Na and dissolved in 100 ml ddH2O/0.9% Saline (0.9 g NaCl in 100 ml ddH2O) to make a clear solution.
Under the condition of stirring and heating (50-65°C), adding CMC-Na slowly to ddH2O/0.9% Saline helps to accelerate dissolution.
Note
1.You must ensure that your CMC-Na solution does not exist solid-liquid separation phenomenon. The solution is in a uniform and transparent state has no particles in it.
2.Completely dissolution of CMC-Na may requires 4 hours or more longer.
In a pharmacological test, CMC-Na (oral;5% in water; 1 year) is well tolerated in rats[2].
In an acute oral toxicity study in female mice, LD50 of CMC-Na for female mice is 14 g/kg body weight of mice, equivalent to 9.8 g/kg body weight of rat, categorized as practically non-toxic according to Loomis criteria (LD50 5-15g/kg body weight of rat)[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 9004-32-4
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Appearance Solid
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Color White to off-white
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SMILES
[Sodium carboxymethyl cellulose (Viscosity:800-1200 mPa.s)]
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Synonyms
CMC-Na (Viscosity:800-1200 mPa.s)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Store at room temperature, keep dry and cool
In solvent -80°C 1 year -20°C 6 months
Publications (49)
All
Journal Impact Factor
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Journal Impact Factor
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Most Recent
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Signal Transduct Target Ther
Oleic acid restores the impaired antitumor immunity of γδ-T cells induced by palmitic acid. [Abstract]2025 Jul 3;10(1):209. PMID: 40603316 -
Bone Res
Nuclear farnesoid X receptor protects against bone loss by driving osteoblast differentiation through stabilizing RUNX2. [Abstract]2025 Jan 30;13(1):20. PMID: 39885145 -
Acta Pharm Sin B
THBru ameliorates atherosclerosis by inhibiting endothelial ferroptosis via regulation of the super-enhancer-associated ABCC1. [Abstract]2025 Dec;15(12):6461-6477. PMID: 41477343 -
Adv Sci (Weinh)
Hepatitis E Virus ORF1 Polyprotein Harbors a Pocket-Like Cavity That Is Vital for Virus Replication and Represents a Novel Antiviral Target. [Abstract]2025 Oct 2:e01699. PMID: 41038801 -
Cancer Lett
Traditional medicine Bazi Bushen potentiates immunosurveillance of senescent liver cancer cells via cGAS-STING signaling activation in macrophages. [Abstract]2025 Feb 8:217544. PMID: 39929434 -
Phytomedicine
Yinchenhao decoction and its active compound rhein ameliorate intrahepatic cholestasis of pregnancy in mice via modulation of intestinal flora. [Abstract]2025 Oct 14:148:157397. PMID: 41135275 -
Phytomedicine
Shexiang baoxin pill ameliorates cardiac fibrosis by inhibiting fibroblast to myofibroblast transition through STAT3 phosphorylation suppression. [Abstract]2025 Sep 15:148:157263. PMID: 40975042 -
Phytomedicine
Cryptotanshinone alleviates immunosuppression in endometriosis by targeting MDSCs through JAK2/STAT3 pathway. [Abstract]2024 Nov 14:136:156227. PMID: 39580997 -
Phytomedicine
Baicalein improves the symptoms of polycystic ovary syndrome by mitigating oxidative stress and ferroptosis in the ovary and gravid placenta. [Abstract]2024 Jun:128:155423. PMID: 38518646 -
Antioxidants (Basel)
Hesperetin, a Promising Dietary Supplement for Preventing the Development of Calcific Aortic Valve Disease. [Abstract]2022 Oct 24;11(11):2093. PMID: 36358465 -
Ecotoxicol Environ Saf
A network toxicology and machine learning approach to investigate the mechanism of kidney injury from melamine and cyanuric acid co-exposure. [Abstract]2025 Mar 15:293:118029. PMID: 40088607 -
Biochem Pharmacol
Mairin polarizes Macrophages into M2-phenotype and alleviates Ulcerative colitis through activating IRF4-CD5L pathway. [Abstract]2026 May:247:117771. PMID: 41651133 -
Biochem Pharmacol
Sesamin ameliorates nonalcoholic hepatic steatosis by inhibiting CD36-mediated hepatocyte lipid accumulation in vitro and in vivo. [Abstract]2024 Jun:224:116240. PMID: 38679210 -
J Ethnopharmacol
Sishen pill alleviates DSS induced colitis through AGE/RAGE/NLRP3 pathway based on transcriptomics analysis. [Abstract]2025 Oct 27:356:120818. PMID: 41161619 -
Mol Ther Oncol
Galunisertib promotes bevacizumab-induced vascular normalization in nasopharyngeal carcinoma: Multi-parameter MRI evaluation. [Abstract]2024 Aug 8;32(3):200858. PMID: 39280586 -
Inflammopharmacology
A medicine and food homology formula prevents cognitive deficits by inhibiting neuroinflammation and oxidative stress via activating AEA-Trpv1-Nrf2 pathway. [Abstract]2024 Dec;32(6):3745-3759. PMID: 39305407 -
Drug Des Devel Ther
Temozolomide-Induced Changes in Gut Microbial Composition in a Mouse Model of Brain Glioma. [Abstract]2021 Apr 21;15:1641-1652. PMID: 33907383 -
Transplantation
Donor Variability and PD-1 Expression Limit BK Polyomavirus-specific T-cell Function and Therapy. [Abstract]2025 Apr 9. PMID: 40200394 -
Transplantation
Activation of the Aryl Hydrocarbon Receptor Ameliorates Acute Rejection of Rat Liver Transplantation by Regulating Treg Proliferation and PD-1 Expression. [Abstract]2022 Nov 1;106(11):2172-2181. PMID: 35706097 -
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Int Immunopharmacol
Kanglexin attenuates spinal cord injury by modulating pyroptosis and polarization via the PKA/NF-κB signaling pathway. [Abstract]2025 Apr 24:153:114401. PMID: 40101425 -
Int Immunopharmacol
Micheliolide ameliorates severe acute pancreatitis in mice through potentiating Nrf2-mediated anti-inflammation and anti-oxidation effects. [Abstract]2024 Oct 27;143(Pt 2):113490. PMID: 39467351 -
Int Immunopharmacol
Dimethyl fumarate ameliorates chronic stress-induced anxiety-like behaviors by decreasing neuroinflammation and neuronal activity in the amygdala. [Abstract]2024 Jun 18:137:112414. PMID: 38897132 -
Int Immunopharmacol
Pirfenidone ameliorates early pulmonary fibrosis in LPS-induced acute respiratory distress syndrome by inhibiting endothelial-to-mesenchymal transition via the Hedgehog signaling pathway. [Abstract]2022 Aug:109:108805. PMID: 35504205 -
Int Immunopharmacol
CTRP3 alleviates myocardial ischemia/reperfusion injury in mice through activating LAMP1/JIP2/JNK pathway. [Abstract]2022 Jun:107:108681. PMID: 35278832 -
RSC Adv
2025 Sep 19;15(41):34300-34309. PMID: 40979958 -
Molecules
Urolithin A Attenuates Periodontitis in Mice via Dual Anti-Inflammatory and Osteoclastogenesis Inhibition: A Natural Metabolite-Based Therapeutic Strategy. [Abstract]2025 Jul 7;30(13):2881. PMID: 40649395 -
Mediators Inflamm
Wogonin, a Bioactive Ingredient from Huangqi Guizhi Formula, Alleviates Discogenic Low Back Pain via Suppressing the Overexpressed NGF in Intervertebral Discs. [Abstract]2023 Feb 20:2023:4436587. PMID: 36860203 -
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J Integr Med
Alisol B 23-acetate promotes white adipose tissue browning to mitigate high-fat diet-induced obesity by regulating mTOR-SREBP1 signaling. [Abstract]2024 Jan;22(1):83-92. PMID: 38311542 -
Biomedicines
Ferulic Acid Alleviates Chemotherapy-Induced POI by Targeting the Grp78 and Perk-eIF2α-ATF4-CHOP Pathway to Attenuate Endoplasmic Reticulum Stress. [Abstract]2026 Mar 19;14(3):714. PMID: 41898358 -
Diabetol Metab Syndr
Electroacupuncture modulates the gut-brain axis via the PI3K/Akt pathway to improve feeding behavior, body weight, glucolipid metabolism, and reduce insulin resistance in T2DM rats. [Abstract]2025 Apr 9;17(1):122. PMID: 40205499 -
Food Sci Nutr
Evaluation of the Effects of Chitin and Chitosan on Pseudo-Allergic Reaction by Inhibiting MRGPRX2 Activation. [Abstract]2025 Sep 1;13(9):e70877. PMID: 40901656 -
PLoS Negl Trop Dis
LFA-1/ ICAM-1 promotes NK cell cytotoxicity associated with the pathogenesis of ocular toxoplasmosis in murine model. [Abstract]2022 Oct 7;16(10):e0010848. PMID: 36206304 -
mSphere
Effect of urolithin A on intracellular survival of Mycobacterium tuberculosis by regulating AKT-FOXO1-mediated autophagy. [Abstract]2025 Apr 10:e0006125. PMID: 40207917 -
J Pharmacol Sci
Hirsutine attenuated oxidative stress and autophagy in diabetic kidney disease through Keap1/Nrf2 pathway. [Abstract]2025 Jun;158(2):143-153. PMID: 40288825 -
Surgery
Emodin alleviates intestinal ischemia/reperfusion-induced lung injury by upregulating HO-1 expression via PI3K/AkT pathway. [Abstract]2024 May 28:S0039-6060(24)00230-7. PMID: 38811326 -
Exp Eye Res
Isorhamnetin suppresses the epithelial-mesenchymal transition of the retinal pigment epithelium both in vivo and in vitro through Nrf2-dependent AKT/GSK-3β pathway. [Abstract]2024 Mar:240:109823. PMID: 38331017 -
PLoS One
Dapagliflozin mitigates myocardial inflammation and metabolic stress in heart failure through STAT1 inhibition: Evidence from multi-omics analyses and experimental exploration. [Abstract]2026 Feb 27;21(2):e0343296. PMID: 41758878 -
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Reprod Sci
Liquiritigenin Restores Declined Oocyte Quality and Improves Embryo Development in Aged Mice. [Abstract]2025 Aug 27. PMID: 40866779 -
Liver Res
Glucokinase activator improves glucose tolerance and induces hepatic lipid accumulation in mice with diet-induced obesity. [Abstract]2023 Jun 2;7(2):124-135. PMID: 39958949 -
Clin Exp Nephrol
Resveratrol glycoside inhibits NLRP3/IL-1β/NF-κB to alleviate peritoneal fibrosis in peritoneal dialysis. [Abstract]2025 Jun 17. PMID: 40526291 -
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Solvent & Solubility
In Vitro:
H2O : 20 mg/mL (ultrasonic and warming and heat to 60°C)
View the Complete Stock Solution Preparation Table
In Vivo:
Working Solution
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: Saline
Solubility: ≥ 5 mg/mL; Clear solution
Purity & Documentation
Select Batch:
Purity:
99.98%
Assay:
99.98%
ee.:
99.98%
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Data Sheet (269 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Calculators
Molarity Calculator
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
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