2. Recombinant Proteins
  3. Cytokines and Growth Factors
  4. EGF Superfamily
  5. TGF-alpha

TGF-alpha

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Transforming growth factor α (TGF-alpha; TGF-α) is a mitogenic polypeptide member of the epidermal growth factor (EGF) family of cytokines. TGF-α is composed of 50 amino acids, and displays 35-40% homology with EGF which is the prototypic member of the EGF superfamily. Like EGF, TGF-α is also a ligand of epidermal growth factor receptor (EGFR). TGF-α binds to the EGFR to stimulate an intact RAS/RAF/MAPK pathway, leading to the transcription of genes associated with cell proliferation, invasion and metastasis.

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