IFN-gamma Receptor
IFN-gamma receptor is a receptor for IFN-gamma, and contains IFNγR1 and IFNγR2 two subunits. IFNγR1 can associate with IFNγR2 to form a functional receptor. Upon binding with IFN-gamma, IFNγR1 and IFNγR2 oligomerize and transphosphorylate[1]. Then, JAK1 and JAK2 are phosphorylated and activated, and STAT1 is recruited to the receptor complex. Phosphorylated STAT1 leads to dimerization and translocates to the nucleus, where it regulates the expression of IFN-responsive genes (e.g. CD54)[2]. IFNγR1 is constitutively expressed on the surface of almost all cells. IFNγR2 is highly expressed on myeloid cells, moderately on B cells and low on T cells. [1]. IFN-gamma receptor plays a critical role in antimicrobial such as mycobacterial infection, antiviral, and antitumor responses[2].
- [1]. Castro F, et al. Interferon-Gamma at the Crossroads of Tumor Immune Surveillance or Evasion. Front Immunol. 2018 May 4;9:847. [Content Brief]
- [2]. van de Vosse E, et al. IFN-γR1 defects: Mutation update and description of the IFNGR1 variation database. Hum Mutat. 2017 Oct;38(10):1286-1296. [Content Brief]
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IFN-gamma Receptor Recombinant Proteins (10)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
