GPR37
GPR37, originally described as an endothelin B receptor-like protein and also known as PAELR (parkin-associated endothelin-like receptor), is an orphan Class A GPCR expressed predominantly in the brain. It gained attention because misfolded GPR37 accumulates in the endoplasmic reticulum and is a substrate of the E3 ubiquitin ligase parkin, linking the receptor to autosomal recessive juvenile Parkinsonism and dopaminergic neuron vulnerability. Later work identified peptides derived from prosaposin as functional ligands that activate GPR37 and GPR37L1, engaging Gi/o and other pathways. Genetic studies have also associated GPR37 variants with autism spectrum disorder, and the receptor has been pursued as a drug target in neurodegeneration.
-
GPR37 Recombinant Proteins (1)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
