1. Immunology/Inflammation
    Protein Tyrosine Kinase/RTK
  2. IRAK

IRAK

Interleukin-1 receptor-associated kinase (IRAK) is first described as a signal transducer for the proinflammatory cytokine IL-1 and is later implicated in signal transduction of other members of the Toll-like receptor (TLR)/IL-1R family. Four different IRAK-like molecules have been identified: two active kinases, IRAK-1 and IRAK-4, and two inactive kinases, IRAK-2 and IRAK-M. All IRAKs mediate activation of NF-κB and MAPK pathways. IRAKs are protein kinases involved in signalling innate immune responses from TLRs. After TLR-4 and TLR-2 recognize pathogen-associated molecular patterns, such as LPS and peptidoglycan, all IRAK members form multimeric receptor complexes.

IRAKs are essential signaling intermediates in the TLR/IL-1R pathway to both IKK and MAPKs activation. These two pathways are central to the activation of several transcription factors, including NF-κB and AP-1, which contribute to the establishment of an immune response.

IRAK Related Products (9):

Cat. No. Product Name Effect Purity
  • HY-13329
    IRAK-1-4 Inhibitor I Inhibitor 98.49%
    IRAK-1-4 Inhibitor I is a dual inhibitor of IRAK4 and IRAK1 with IC50 of 0.2 μM and 0.3 μM, respectively.
  • HY-13275
    IRAK inhibitor 1 Inhibitor 99.47%
    IRAK inhibitor 1 is a potent IRAK-4 inhibitor with IC50 of 216 nM, is poorly active against JNK-1 and JNK-2 with IC50 of 3.801 μM, and >10 μM, respectively.
  • HY-19836
    PF06650833 Inhibitor 98.68%
    PF06650833 is an inhibitor of Interleukin-1 receptor associated kinase 4 (IRAK4), and used to treat diseases such as rheumatoid arthritis, lupus, and lymphomas.
  • HY-13280
    IRAK inhibitor 6 Inhibitor
    IRAK inhibitor 6 is interleukin-1 receptor associated kinase 4 (IRAK-4) inhibitor .
  • HY-13278
    IRAK inhibitor 4 Inhibitor 98.05%
    IRAK inhibitor 4 is an interleukin-1 receptor associated kinase 4(IRAK4) inhibitor.
  • HY-103017
    JH-X-119-01 hydrochloride Inhibitor
    JH-X-119-01 hydrochloride is a potent IRAK1 inhibitor.
  • HY-13277
    IRAK inhibitor 3 Modulator
    IRAK inhibitor 3 is an interleukin-1 (IL-I) receptor-associated kinase (IRAK) kinase modulator extracted from patent WO2008030579 A2.
  • HY-13276
    IRAK inhibitor 2 Inhibitor
    IRAK inhibitor 2 is interleukin-1 receptor associated kinase inhibitor .
  • HY-13278A
    IRAK inhibitor 4 trans Inhibitor 99.50%
    IRAK inhibitor 4 (trans) is the trans form of IRAK inhibitor 4.