1. PROTAC
    Protein Tyrosine Kinase/RTK
    Immunology/Inflammation
  2. PROTAC
    IRAK
  3. PROTAC IRAK4 degrader-1

PROTAC IRAK4 degrader-1 

Cat. No.: HY-129966
Handling Instructions

PROTAC IRAK4 degrader-1 is a PROTAC interleukin-1 receptor-associated kinase 4 (IRAK4) degrader extracted from patent US20190192668A1 Compound I-210, makes <20%, >20-50%, and >50% IRAK4 degradation at 0.01, 0.1, and 1 μM in OCI-LY-10 cells, respectively.

For research use only. We do not sell to patients.

PROTAC IRAK4 degrader-1 Chemical Structure

PROTAC IRAK4 degrader-1 Chemical Structure

CAS No. : 2360533-90-8

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Description

PROTAC IRAK4 degrader-1 is a PROTAC interleukin-1 receptor-associated kinase 4 (IRAK4) degrader extracted from patent US20190192668A1 Compound I-210, makes <20%, >20-50%, and >50% IRAK4 degradation at 0.01, 0.1, and 1 μM in OCI-LY-10 cells, respectively[1].

IC50 & Target

IRAK4

 

Cereblon

 

Molecular Weight

904.85

Formula

C₄₄H₃₉F₃N₁₂O₇

CAS No.

2360533-90-8

SMILES

O=C(C1=CC=C(N2C=C(NC(C3=COC(C4=CC=NC(NCC5CC5)=C4)=N3)=O)C(C(F)(F)F)=N2)C=C1)NCCCN(C=N6)C=C6CNC7=C8C(C(N(C9C(NC(CC9)=O)=O)C8=O)=O)=CC=C7

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

PROTAC IRAK4 degrader-1PROTACIRAKProteolysis-targeting chimeraInterleukin-1 receptor associated kinaseIL-1R associated kinaseIRAK4DegraderDiffuselargeB-celllymphomaInhibitorinhibitorinhibit

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PROTAC IRAK4 degrader-1
Cat. No.:
HY-129966
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