IRAK4

IRAK4 Related Products (34):

By Type:	Pan (16) Selective (13)

Cat. No.	Product Name	Effect	Purity

HY-19836

Zimlovisertib	Inhibitor	99.84%
Zimlovisertib (PF-06650833) is a potent, selective and orally active inhibitor of interleukin-1 receptor associated kinase 4 (IRAK4) with IC₅₀s of 0.2 and 2.4 nM in the cell and PBMC assay, respectively.

HY-135317

Emavusertib	Inhibitor	99.96%
Emavusertib (CA-4948) is a potent IRAK4/FLT3 inhibtor with anti-tumor activity.

HY-129966

PROTAC IRAK4 degrader-1	Inhibitor	99.72%
PROTAC IRAK4 degrader-1 is a Cereblon-based PROTAC interleukin-1 receptor-associated kinase 4 (IRAK4) degrader extracted from patent US20190192668A1 Compound I-210, makes <20%, >20-50%, and >50% IRAK4 degradation at 0.01, 0.1, and 1 μM in OCI-LY-10 cells, respectively.

HY-147141

HS-276	Inhibitor	98.59%
HS-276 is an orally active, potent and highly selective TAK1 inhibitor, with a K_i of 2.5 nM.

HY-111101

AZ1495	Inhibitor	98.18%
AZ1495, a weak base, is a potent orally active interleukin-1 receptor associated kinase 4 (IRAK4) inhibitor.

HY-148277

KTX-612
KTX-612 is an orally active IRAK4 degrader with a DC₅₀ value of 7 nM.

HY-148276

KTX-497
KTX-497 is an IRAK4 degrader with a DC₅₀ value of 3 nM.

HY-148275

KTX-955	Inhibitor
KTX-955 is a potent IRAK4 degrader with DC₅₀ values of 5 nM and 130 nM for IRAK4 and Ikaros, respectively.

HY-109585

IRAK4-IN-7	Inhibitor	99.86%
IRAK4-IN-7 is a selective, potent and orally active interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor, extracted from patent WO2015104688 (example 1).

HY-123854

PF-06426779	Inhibitor	99.83%
PF-06426779 is a potent and selective inhibitor of interleukin‑1 receptor associated kinase 4 (IRAK4), with an IC₅₀ of 0.3 nM.

HY-77048

IRAK-4 protein kinase inhibitor 2	Inhibitor	99.48%
IRAK-4 protein kinase inhibitor 2 (compound 1) is a potent inhibitor of interleukin-1 (IL-1) receptor-associated kinase-4 (IRAK-4), with an IC₅₀ of 4 μM.

HY-145483

PROTAC IRAK4 degrader-7	Inhibitor
PROTAC IRAK4 degrader-7 (Compound I-417) is an orally active PROTAC IRAK4 degrader with antitumor activities.

HY-131903

HS271	Inhibitor	99.92%
HS271 is a highly potent, orally active and selective IRAK4 inhibitor, with an IC₅₀ of 7.2 μM.

HY-134911

HS-243	Inhibitor	99.88%
HS-243 is a potent and selective IRAK-4 and IRAK-1 inhibitor, with IC₅₀ values of 20 and 24 nM.

HY-18992

AS2444697	Inhibitor	98.13%
AS2444697 is an orally active IRAK-4 inhibitor with an IC₅₀ of 21 nM.

HY-135382A

PROTAC IRAK4 degrader-3	Inhibitor
PROTAC IRAK4 degrader-3 is a PROTAC-induced IRAK4 degrader based on von Hippel-Lindau.

HY-143231

IRAK4-IN-8	Inhibitor
IRAK4-IN-8 (VI-177) is a potent IRAK4 inhibitor.

HY-150732

IRAK4-IN-18	Inhibitor
IRAK4-IN-18 is a potent interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor with an IC₅₀ value of 15 nM.

HY-139316

PROTAC IRAK4 degrader-5	Inhibitor
PROTAC IRAK4 degrader-5 is a Cereblon-based IRAK4 degrader extracted from patent US20190192668A1, compound I-171.

HY-150593

IRAK4-IN-16	Inhibitor
IRAK4-IN-16 (compound 4) is a potent IRAK4 (interleukin-1 receptor associated kinase 4) inhibitor, with an IC₅₀ of 2.5 nM.

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