848249-10-5
848249-10-5
Chemical Structure
HS-243
- CAS No.: 848249-10-5
- Formula:C17H16N4O3
- Molecular Weight:324.33
IUPAC Name: 3-nitro-N-(1-propyl-1H-benzo[d]imidazol-2-yl)benzamide
InChIKey: JLLIANWHDQWCMY-UHFFFAOYSA-N
SMILES: O=C(NC1=NC2=CC=CC=C2N1CCC)C3=CC=CC([N+]([O-])=O)=C3
Biological Activity: HS-243 is a potent and selective IRAK-4 and IRAK-1 inhibitor, with IC50 values of 20 and 24 nM. HS-243 shows minimal TAK1 (transforming growth factor β-activated kinase 1) inhibition activity, with a IC50 of 0.5 μM. HS-243 shows anti-inflammatory and anticancer activity[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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HS-243 | 99.95% | HS-243 is a potent and selective IRAK-4 and IRAK-1 inhibitor, with IC50 values of 20 and 24 nM. HS-243 shows minimal TAK1 (transforming growth factor β-activated kinase 1) inhibition activity, with a IC50 of 0.5 μM. HS-243 shows anti-inflammatory and anticancer activity. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.83
HY-103490Takinib -
Similarity Score 0.82
HY-122642TAK1-IN-4 -
Similarity Score 0.77
HY-13329IRAK-1-4 Inhibitor I -
Similarity Score 0.74
HY-77048IRAK-4 protein kinase inhibitor 2 -
Similarity Score 0.67
HY-135841CM010 -
Similarity Score 0.63
HY-148040VEGFR-2-IN-29 -
Similarity Score 0.62
HY-110107AGW438014A free base -
Similarity Score 0.61
HY-110107GW438014A -
Similarity Score 0.61
HY-Z8270Mebendazole impurity 3 -
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