Betacellulin
Betacellulin (BTC) is a member of the epidermal growth factor (EGF) family which was originally identified as a secreted growth factor from pancreatic β-cell insulinomas. BTC is synthesized in a wide range of tissues of the adult body and in a large number cultured cells, including smooth muscle cells and epithelial cells. BTC has a high affinity and specificity for ErbB1/EGFR and ErbB4 and induces the growth of certain epithelial cell types. Homologous or heterologous dimers of ErbB family receptor are then formed to activate signal transduction pathways, such as PI3K/PDK1/Akt and RAS/RAF/MEK/Erk, leading to a series of biological effects. BTC has been implicated in a number of physiologic processes, including β-cell proliferation, keratinocyte proliferation and angiogenesis. BTC acts as an important regulator of ovarian follicle development, and can stimulate oocyte maturation and cumulus expansion.
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Betacellulin Recombinant Proteins (6)
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
