2. Recombinant Proteins
  3. Cytokines and Growth Factors
  4. EGF Superfamily
  5. Betacellulin

Betacellulin

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Betacellulin (BTC) is a member of the epidermal growth factor (EGF) family which was originally identified as a secreted growth factor from pancreatic β-cell insulinomas. BTC is synthesized in a wide range of tissues of the adult body and in a large number cultured cells, including smooth muscle cells and epithelial cells. BTC has a high affinity and specificity for ErbB1/EGFR and ErbB4 and induces the growth of certain epithelial cell types. Homologous or heterologous dimers of ErbB family receptor are then formed to activate signal transduction pathways, such as PI3K/PDK1/Akt and RAS/RAF/MEK/Erk, leading to a series of biological effects. BTC has been implicated in a number of physiologic processes, including β-cell proliferation, keratinocyte proliferation and angiogenesis. BTC acts as an important regulator of ovarian follicle development, and can stimulate oocyte maturation and cumulus expansion.

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Cat. No. Product Name / Synonyms Species Source
  • HY-P7328
    Betacellulin Protein, Human (HEK293)

    rHuBetacellulin; BTC

    		Human HEK293
    Probetacellulin Protein, Human (HEK293) is a glycoprotein produced in HEK293 cells, improves glucose tolerance by promoting β-cell differentiation and regeneration from ductal and/or acinar cells.
  • HY-P7005
    Betacellulin Protein, Human

    rHuBetacellulin; Probetacellulin; BTC

    		Human E. coli
    Probetacellulin Protein, Human is a glycoprotein, improves glucose tolerance by promoting β-cell differentiation and regeneration from ductal and/or acinar cells.
  • HY-P7142
    Betacellulin/BTC Protein, Mouse (HEK293)

    rMuBetacellulin; BTC; Probetacellulin

    		Mouse HEK293
    Probetacellulin Protein, Mouse (HEK293), a member of the epidermal growth factor (EGF) family, induces differentiation of pancreatic β-cells and promotes regeneration of β-cells in experimental diabetes.
  • HY-P7329
    Betacellulin/BTC Protein, Mouse (N-His)

    rMuBetacellulin; BTC

    		Mouse E. coli
    Probetacellulin Protein, Mouse, induces differentiation of pancreatic β-cells and promotes regeneration of β-cells in experimental diabetes.
  • HY-P77303
    Betacellulin/BTC Protein, Cynomolgus (HEK293, Fc)

    Btc; Betacellulin; Betacellulin epidermal growth factor family member

    		Cynomolgus HEK293
    Betacellulin/BTC Protein, a member of the epidermal growth factor (EGF) family, is known to play an important role in regulating growth and differentiation of pancreatic beta cells. And it is a growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. In addition, BTC exerts potent mitogenic effects on retinal pigment epithelial cells and vascular smooth muscle cells as a monomer. Betacellulin/BTC Protein, Cynomolgus (HEK293, Fc) is the recombinant cynomolgus-derived Betacellulin/BTC protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Betacellulin/BTC Protein, Cynomolgus (HEK293, Fc) is 111 a.a., with molecular weight of 45-55 kDa.
  • HY-P75478
    Betacellulin/BTC Protein, Mouse (HEK293, His-hFc)

    Btc; Betacellulin; Betacellulin epidermal growth factor family member

    		Mouse HEK293
    Betacellulin/BTC Protein, a growth factor with affinity for EGFR, ERBB4, and other EGF receptor family members, exerts potent mitogenic effects on retinal pigment epithelial cells and vascular smooth muscle cells as a monomer. Its molecular activity involves interactions with EGFR and ERBB4, contributing to cellular signaling and regulation. Betacellulin/BTC Protein, Mouse (HEK293, His-hFc) is the recombinant mouse-derived Betacellulin/BTC protein, expressed by HEK293 , with C-hFc, C-His labeled tag. The total length of Betacellulin/BTC Protein, Mouse (HEK293, His-hFc) is 87 a.a., with molecular weight of 50-55 kDa.
  • HY-P70073
    Betacellulin/BTC Protein, Mouse (His)

    rMuBetacellulin/Btc, His; Btc; Betacellulin; Betacellulin; epidermal growth factor family member; Betacellulin; epidermal growth factor family member; isoform CRA_a; mCG_12529

    		Mouse E. coli
    Betacellulin (BTC) is missing crucial conserved residue(s) for feature annotation propagation. Betacellulin/BTC Protein, Mouse (His) is the recombinant mouse-derived Betacellulin/BTC protein, expressed by E. coli , with N-6*His labeled tag. The total length of Betacellulin/BTC Protein, Mouse (His) is 87 a.a., with molecular weight of 13-16 kDa.
  • HY-P77305
    BLOT2 Protein, Blomia tropicalis (HEK293, His)

    Type 2 allergen Blo t 2.047

    		Others HEK293
    BLOT1 Protein is a Blomia tropicalis allergen and is highly homologous to cysteine proteases. BLOT1 may play a major role as an immunodominant allergen involved in dust mite-specific IgE-mediated hypersensitivity. BLOT1, like the other group 1 HDM allergens, is a digestive enzyme associated with mite fecal pellets. BLOT2 Protein, Blomia tropicalis (HEK293, His) is the recombinant BLOT2 protein, expressed by HEK293 , with N-6*His labeled tag. The total length of BLOT2 Protein, Blomia tropicalis (HEK293, His) is 144 a.a., with molecular weight of ~15 KDa.
Cat. No. Product Name Effect Purity