1. Recombinant Proteins
  2. Cytokines and Growth Factors
  3. EGF Superfamily
  4. EGF

Epidermal growth factor (EGF) is the prototypic member of the EGF superfamily of peptide growth factors, which is compose of a single-chain polypeptide containing a total of 53 amino acid residues. EGF is synthesized as a precursor consisting of 1217 amino acid residues, from which the mature form may be generated by proteolysis. EGF is a potent mitogenic factor, which acts by binding with high affinity to the cell surface receptor, epidermal growth factor receptor (EGFR/ErbB). EGF plays an important role in the growth, proliferation and differentiation of numerous cell types, especially fibroblasts and epithelial cells. . Defects in EGF gene are the cause of hypomagnesemia type 4. In addition, dysregulation of this gene has been associated with the growth and progression of certain cancers.

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