CRBN Ligand Library

Cat. No.: HY-L934

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CRBN, namely cereblon, is the substrate recognition subunit of the E3 ubiquitin ligase complex in the ubiquitin-proteasome system. A CRBN ligand library refers to a collection of numerous fragments that can specifically bind to the CRBN protein.

These ligands are mostly designed based on validated CRBN-binding warheads and modified through AI-driven molecular generation optimization systems. They not only include classic lenalidomide-derived structures but also cover novel non-lenalidomide scaffolds. After drug-likeness filtering, these ligands exhibit structural diversity and favorable druggable properties. They can be further optimized and modified to facilitate the development of novel molecular glue degraders, accelerate the discovery of molecular glues that induce interactions between CRBN and new substrate proteins, and enable the exploration of novel CRBN substrates for identifying previously unknown CRBN-binding proteins.

MCE compiles 121 fragments that can specifically bind to the CRBN protein, with molecular weights ranging from 200 to 500. Compounds developed based on the library ligands target multiple disease targets such as cancer and autoimmune diseases, further advancing the development of Molecular Glues and PROTACs therapeutic agents.

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Description & Advantages

• MCE has compiled 121 small-molecule fragments that specifically bind to CRBN protein for molecular glue research.

• It is obtained via pharmacophore screening based on classic CRBN ligands, and can be further optimized and modified to facilitate the development of novel Molecular Glue and PROTAC degraders.

• All compounds are available off the shelf.

• All compounds are validated by LC-MS or NMR to ensure high purity and quality.

Product Details

Formulation:

A compound library can be compiled to include small-molecule fragments that specifically bind to the CRBN protein.
Solution: 121 compounds supplied in 10 mM solution.

Container:

96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode.

Storage:

-80°C

Shipping:

Blue ice or dry ice

Documentation

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Library Handling Instructions (351 KB)

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