InsR
The insulin receptor (InsR) family of receptor tyrosine kinases comprises INSR, IGF1R and the orphan INSRR. Their mature receptors are disulfide-linked (αβ)2 tetramers with extracellular fibronectin type III and cysteine-rich domains, a feature unique among receptor tyrosine kinases. Ligand binding to the α-subunit releases autoinhibition, allowing trans-phosphorylation of the β-subunit and recruitment of IRS proteins and Shc, which activate PI3K-AKT and MAPK pathways governing glucose uptake, protein synthesis, growth and longevity. INSR isoforms mediate insulin action in metabolism, while IGF1R drives prenatal and postnatal growth and is reactivated in many cancers. Agents targeting this family range from insulin analogues and antibodies to IGF1R inhibitors in oncology trials.
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InsR Recombinant Proteins (3)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
