INSRR/IRR
INSRR (insulin receptor-related receptor, IRR) is the third and most mysterious member of the insulin receptor family. It is an orphan receptor: despite extensive searches, no peptide ligand has been identified, and its extracellular domain has diverged greatly from INSR and IGF1R. Strikingly, IRR has been shown to function not as a ligand receptor but as an alkali sensor: modestly elevated extracellular pH directly triggers its kinase activity. IRR is expressed in renal intercalated cells, gastric mucosa and pancreatic beta cells, where it mediates alkali-stimulated hormonal responses and contributes to bicarbonate excretion and acid-base homeostasis. This sensor function, unique among receptor tyrosine kinases, was confirmed by knockout mice showing impaired alkali response.
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INSRR/IRR Recombinant Proteins (1)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formel: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
