1. Membrane Transporter/Ion Channel
  2. Na+/K+ ATPase

Na+/K+ ATPase

Na+/K+ ATPase (Sodium potassium pump) is a transmembrane protein complex found in all higher eukaryotes acting as a key energy-consuming pump maintaining ionic and osmotic balance in cells. Na+/K+ ATPase is an emerging cancer target that merits further investigation.

The constant activity of the Na+/K+-ATPase (NKA, or Na+ pump) is essential for re-establishing and maintaining this gradient. In cardiac and vascular smooth muscle the principal isoforms of the NKA are α1 and α2 and their physiological role is controlled both by their unique and independent signalling pathways, and their discrete subcellular distribution.

Na+/K+ ATPase Related Products (14):

Cat. No. Product Name Effect Purity
  • HY-B1049
    Digoxin Inhibitor 98.46%
    Digoxin is a cardiac glycoside that blocks the sodium-potassium ATPase, as a potent inhibitor of chikungunya virus (CHIKV) infection.
  • HY-15718A
    Istaroxime hydrochloride Inhibitor 99.32%
    Istaroxime hydrochloride is a potent inhibitor of Na+,K+-ATPase with IC50 of 0.11 μM.
  • HY-B0542
    Ouabain Octahydrate Inhibitor 99.79%
    Ouabain Octahydrate is an inhibitor of Na+/K+-ATPase, used for the treatment of congestive heart failure.
  • HY-N0143
    Phlorizin Inhibitor
    Phlorizin is a non-selective SGLT inhibitor with Kis of 300 and 39 nM for hSGLT1 and hSGLT2, respectively. Phlorizin is also a Na+/K+-ATPase inhibitor.
  • HY-N0039
    Ginsenoside Rb1 Inhibitor >98.0%
    Ginsenoside Rb1, a main constituent of the root of Panax ginseng, inhibits Na+, K+-ATPase activity with an IC50 of 6.3±1.0 μM. Ginsenoside also inhibits IRAK-1 activation and phosphorylation of NF-κB p65 .
  • HY-B1357
    Digitoxin Inhibitor 98.23%
    Digitoxin is an effective Na+/K+-ATPase inhibitor, the EC50 value of Digitoxin is 0.78 μM.
  • HY-13719
    Oleandrin Inhibitor 99.84%
    Oleandrin inhibits the Na+, K+-ATPase activity with an IC50 of 620 nM.
  • HY-12283
    Rostafuroxin Antagonist
    Rostafuroxin(PST 2238) is a antihypertensive compound; Na,K-ATPase antognist;displaced [3H]ouabain from the dogkidney Na+,K+-ATPase with IC50 of 1.5 nM.
  • HY-B1429
    Chlorpropamide Inhibitor 99.24%
    Chlorpropamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM).
  • HY-B1237
    Suloctidil Inhibitor 99.82%
    Suloctidil is a new drug that is currently being evaluated in many clinical trials for use in dementia and thrombotic disorders.
  • HY-19556
    (+)-SJ733 Inhibitor 99.45%
    (+)-SJ733 is a clinical candidate for malaria which can also inhibit Na+-ATPase PfATP4.
  • HY-15718
    Istaroxime Inhibitor
    Istaroxime is a potent inhibitor of Na+,K+-ATPase with IC50 of 0.11 μM.
  • HY-B0137A
    Prilocaine hydrochloride Inhibitor
    Prilocaine hydrochloride is a local anesthetic of the amino amide type.
  • HY-B0137
    Prilocaine Inhibitor
    Prilocaine is a local anesthetic of the amino amide type.
Isoform Specific Products

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.