2. Anti-infection
  3. Bacterial Antibiotic
  4. Gramicidin S

Gramicidin S  (Synonyms: Gramicidin soviet)

Cat. No.: HY-P5712 Purity: 99.19%
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Gramicidin S (Gramicidin soviet) is a cationic cyclic peptide antibiotic. Gramicidin S is active against Gram-negative and Gram-positive bacteria by perturbing integrity of the bacterial membranes. Gramicidin S also inhibits cytochrome bd quinol oxidase.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Gramicidin S Chemical Structure

Gramicidin S Chemical Structure

CAS No. : 113-73-5

Size Price Stock Quantity
1 mg USD 150 In-stock
5 mg USD 450 In-stock
10 mg USD 650 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Gramicidin S (Gramicidin soviet) is a cationic cyclic peptide antibiotic. Gramicidin S is active against Gram-negative and Gram-positive bacteria by perturbing integrity of the bacterial membranes. Gramicidin S also inhibits cytochrome bd quinol oxidase[1].

Molecular Weight

1141.45

Formula

C60H92N12O10
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

cyclo(Val-Orn-Leu-D-Phe-Pro)2
Sequence Shortening

cyclo(VOLDFP)2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (87.61 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8761 mL 4.3804 mL 8.7608 mL
5 mM 0.1752 mL 0.8761 mL 1.7522 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.8761 mL 4.3804 mL 8.7608 mL 21.9020 mL
5 mM 0.1752 mL 0.8761 mL 1.7522 mL 4.3804 mL
10 mM 0.0876 mL 0.4380 mL 0.8761 mL 2.1902 mL
15 mM 0.0584 mL 0.2920 mL 0.5841 mL 1.4601 mL
20 mM 0.0438 mL 0.2190 mL 0.4380 mL 1.0951 mL
25 mM 0.0350 mL 0.1752 mL 0.3504 mL 0.8761 mL
30 mM 0.0292 mL 0.1460 mL 0.2920 mL 0.7301 mL
40 mM 0.0219 mL 0.1095 mL 0.2190 mL 0.5475 mL
50 mM 0.0175 mL 0.0876 mL 0.1752 mL 0.4380 mL
60 mM 0.0146 mL 0.0730 mL 0.1460 mL 0.3650 mL
80 mM 0.0110 mL 0.0548 mL 0.1095 mL 0.2738 mL
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Gramicidin S Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Gramicidin S113-73-5Gramicidin sovietBacterialAntibioticantimicrobialpeptideantibacterialGram-negativeGram-positiveInhibitorinhibitorinhibit

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