Synthesis and biological evaluation of asymmetric gramicidin S analogues containing modified D-phenylalanine residues

  • Bioorg Med Chem. 2009 Sep 1;17(17):6318-28. doi: 10.1016/j.bmc.2009.07.042.
Matthijs van der Knaap  1 ,  Eefje Engels ,  Henk J Busscher ,  José M Otero ,  Antonio L Llamas-Saiz ,  Mark J van Raaij ,  Roos H Mars-Groenendijk ,  Daan Noort ,  Gijsbert A van der Marel ,  Herman S Overkleeft ,  Mark Overhand
Affiliations
  • 1. Bio-Organic Synthesis, Leiden Institute of Chemistry, University of Leiden, Leiden, The Netherlands.
PMID: 19674904 DOI: 10.1016/j.bmc.2009.07.042
Abstract

The synthesis of new analogues of the cationic antimicrobial peptide gramicidin S, having a modified D-phenylalanine residue, their Antibacterial properties against several gram positive and negative strains, as well as their hemolytic activity is reported.