Fc gamma RIII/CD16
FcγRIII, also known as CD16, is the type III Fcγ receptor. It exists as two isoforms in humans, FcγRIIIa and FcγRIIIb, sharing 96% sequence identity in their extracellular immunoglobulin binding regions. FcγRIIIa is expressed on macrophages, mast cells, and natural killer cells as a transmembrane receptor. Present exclusively on neutrophils, FcγRIIIb is the only Fc receptor anchored by a GPI (glycosyl-phosphatidylinositol) linker to the plasma membrane. Despite the lack of a signaling component, FcγRIIIb plays an active role in triggering Ca2+ mobilization and neutrophil degranulation. In addition, in conjunction with FcγRIIa, FcγRIIIb activates phagocytosis, degranulation, and oxidative burst, which lead to the clearance of opsonized pathogens by neutrophils.
-
Fc gamma RIII/CD16 Recombinant Proteins (27)
- Species:
- Source:
- Species:
- Source:
- Species:
- Source:
- Species:
- Source:
- Species:
- Source:
- 1
- 2
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- 1
- 2
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
