1. Recombinant Proteins
  2. Fc Receptors
  3. Fc-gamma Receptor
  4. Fc gamma RIII/CD16

FcγRIII, also known as CD16, is the type III Fcγ receptor. It exists as two isoforms in humans, FcγRIIIa and FcγRIIIb, sharing 96% sequence identity in their extracellular immunoglobulin binding regions. FcγRIIIa is expressed on macrophages, mast cells, and natural killer cells as a transmembrane receptor. Present exclusively on neutrophils, FcγRIIIb is the only Fc receptor anchored by a GPI (glycosyl-phosphatidylinositol) linker to the plasma membrane. Despite the lack of a signaling component, FcγRIIIb plays an active role in triggering Ca2+ mobilization and neutrophil degranulation. In addition, in conjunction with FcγRIIa, FcγRIIIb activates phagocytosis, degranulation, and oxidative burst, which lead to the clearance of opsonized pathogens by neutrophils.

Cat. No. Product Name / Synonyms Species Source
Cat. No. Product Name Effect Purity