Checkpoint Kinase 2 (Chk2)
Checkpoint Kinase 2 (Chk2, CHEK2) operates downstream of ATM in the DNA double-strand break response. ATM phosphorylates Chk2, promoting its dimerization and activation, after which the kinase phosphorylates p53, BRCA1, PPM1D and CDC25A to halt the cycle, support repair or trigger apoptosis. Bi-allelic loss is rare in tumors, but heterozygous truncating CHEK2 variants, especially the founder allele 1100delC, raise breast cancer risk several-fold and define a moderate-penetrance cancer predisposition syndrome. Chk2 is thus both a checkpoint kinase and a well-established human cancer susceptibility gene.
-
Checkpoint Kinase 2 (Chk2) Recombinant Proteins (4)
-
Inhibitors & Agonists (51)
- Species:
- Source:
- Species:
- Source:
- Species:
- Source:
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Fòrmula: Human
- Peso molecular: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
