1. Signaling Pathways
  2. Apoptosis
  3. RIP kinase

RIP kinase

Receptor interacting protein 2 (RIP2), a serine/threonine kinase, is an adaptor molecule of NOD1 and NOD2, and genetic variation in this receptor is known to be associated with the severity of allergic asthma in children.

Receptor interacting protein kinase 2 (RIPK2) is critical for NOD-mediated NF-κB activation and cytokine production. WEHI-345, a selective RIPK2 kinase inhibitor, which delays RIPK2 ubiquitylation and NF-κB activation downstream of NOD engagement.

Receptor interacting protein kinase 3 (RIPK3) is a cytosolic master regulator of necroptosis. RIPK3 has an active serine/threonine kinase domain at the N-terminus, and a unique protein-protein interaction domain called the RIP homotypic interaction motif (RHIM) at the C-terminus. Both kinase activity and RHIM are indispensable for necroptosis. RIPK3 interacts with other RHIM-containing proteins such as RIPK1, Toll/interleukin-1 (IL-1) receptor domain-containing adaptor protein inducing interferon β (TRIF) or DNA-dependent activator of interferon regulatory factor (DAI). RIPK3 induces necroptosis, a type of regulated necrosis, through its kinase domain and RHIM.

RIP kinase Related Products (18):

Cat. No. Product Name Effect Purity
  • HY-15760
    Necrostatin-1 Inhibitor 99.20%
    Necrostatin-1 (Nec-1) is a potent, selective and cell-permeable necroptosis inhibitor with an EC50 of 490 nM in Jurkat cells. It acts by inhibiting the death domain kinase RIP (RIP1) in the necroptosis pathway.
  • HY-101872
    GSK'872 Inhibitor 99.65%
    GSK'872 (GSK872) is a RIPK3 inhibitor, which binds RIP3 kinase domain with an IC50 of 1.8 nM, and inhibits kinase activity with an IC50 of 1.3 nM.
  • HY-101760
    GSK2982772 Inhibitor >98.0%
    GSK2982772 is a potent and ATP competitive RIP1 inhibitor with an IC50 of 16 nM.
  • HY-101032
    RIPA-56 Inhibitor 99.86%
    RIPA-56 is a highly potent, selective, and metabolically stable inhibitor of receptor-interacting protein 1 (RIP1) with an IC50 of 13 nM.
  • HY-18937
    WEHI-345 Inhibitor 98.56%
    WEHI-345 is a potent and selective inhibitor of RIPK2, with IC50 of 0.13 μM.
  • HY-114492
    GSK547 Inhibitor
    GSK547, a highly selective and potent RIP1 inhibitor, inhibits macrophage-mediated adaptive immune tolerance in pancreatic cancer.
  • HY-104021
    GSK840 Inhibitor >98.0%
    GSK840 (GSK'840) is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor with IC50s of 0.9 nM and 0.3 nM by fluorescence polarization (FP) and ADP-Glo assay, respectively.
  • HY-125466
    cRIPGBM, a proapoptotic derivative of RIPGBM, a cell type-selective inducer of apoptosis in GBM cancer stem cells (CSCs) by binding to receptor-interacting protein kinase 2 (RIPK2), with an EC50 of 68 nM in GBM-1 cells.
  • HY-100339
    GSK583 Inhibitor 98.64%
    GSK583 is a highly potent and selective inhibitor of RIP2 Kinase, with IC50 of 5 nM.
  • HY-19764
    RIP2 kinase inhibitor 1 Inhibitor 98.11%
    RIP2 kinase inhibitor 1 is a receptor interacting protein-2 (RIP2) kinase inhibitor extracted from patent WO/2014043446 A1, compound example 1.
  • HY-100131
    GSK'481 Inhibitor >98.0%
    GSK'481 can inhibit RIP1 WT S166 phosphorylation in human vs mouse plasmids overexpressed in HEK293T cells.
  • HY-19761
    RIP2 kinase inhibitor 2 Inhibitor 99.95%
    RIP2 kinase inhibitor 2 is a receptor interacting protein-2 (RIP2) kinase inhibitor extracted from patent WO/2014043437 A1, compound example 9.
  • HY-103028A
    GSK963 Inhibitor
    GSK963 is a chiral, highly potent and selective inhibitor of RIP1 kinase, with an IC50 of 29 nM. GSK963 is a selective and potent inhibitor of necroptosis in murine and human cells in vitro.
  • HY-122909
    GSK2593074A Inhibitor
    GSK2593074A (GSK’074) is a necroptosis inhibitor with dual targeting ability to both RIP1 and RIP3.
  • HY-114349
    HS-1371 Inhibitor 98.49%
    HS-1371 is a potent and ATP-competitive receptor-interacting protein kinase 3 (RIP3) inhibitor with an IC50 of 20.8 nM.
  • HY-125402
    GSK-843 Inhibitor >98.0%
    GSK-843 is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor with IC50s of 8.6 nM and 6.5nM by fluorescence polarization (FP) and ADP-Glo assay, respectively.
  • HY-111946
    GSK3145095 Inhibitor
    GSK3145095 is a RIP1 kinase inhibitor with an IC50 of 6.3 nM .
  • HY-18900
    Nec-4 Inhibitor
    Nec-4, a tricyclic derivative, is a potent receptor interacting protein 1 (RIP1) inhibitor, with an IC50 of 2.6 μM, Ki of 0.46 μM.
Isoform Specific Products

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