1. Apoptosis
  2. RIP kinase

RIP kinase

Receptor interacting protein 2 (RIP2), a serine/threonine kinase, is an adaptor molecule of NOD1 and NOD2, and genetic variation in this receptor is known to be associated with the severity of allergic asthma in children.

Receptor interacting protein kinase 2 (RIPK2) is critical for NOD-mediated NF-κB activation and cytokine production. WEHI-345, a selective RIPK2 kinase inhibitor, which delays RIPK2 ubiquitylation and NF-κB activation downstream of NOD engagement.

Receptor interacting protein kinase 3 (RIPK3) is a cytosolic master regulator of necroptosis. RIPK3 has an active serine/threonine kinase domain at the N-terminus, and a unique protein-protein interaction domain called the RIP homotypic interaction motif (RHIM) at the C-terminus. Both kinase activity and RHIM are indispensable for necroptosis. RIPK3 interacts with other RHIM-containing proteins such as RIPK1, Toll/interleukin-1 (IL-1) receptor domain-containing adaptor protein inducing interferon β (TRIF) or DNA-dependent activator of interferon regulatory factor (DAI). RIPK3 induces necroptosis, a type of regulated necrosis, through its kinase domain and RHIM.

RIP kinase Related Products (9):

Cat. No. Product Name Effect Purity
  • HY-15760
    Necrostatin-1 Inhibitor 99.20%
    Necrostatin-1 is a specific inhibitor of the receptor-interacting protein 1 (RIP1) kinase domain, inhibits necroptosis with EC50 of 490 nM in Jurkat cells.
  • HY-18937
    WEHI-345 Inhibitor 98.56%
    WEHI-345 is a potent and selective inhibitor of RIPK2, with IC50 of 0.13 μM.
  • HY-100339
    GSK583 Inhibitor 98.07%
    GSK583 is a highly potent and selective inhibitor of RIP2 Kinase, with IC50 of 5 nM.
  • HY-101760
    GSK2982772 Inhibitor >98.0%
    GSK2982772 is a potent and ATP competitive RIP1 inhibitor with an IC50 of 16 nM.
  • HY-19764
    RIP2 kinase inhibitor 1 Inhibitor
    RIP2 kinase inhibitor 1 is a receptor interacting protein-2 (RIP2) kinase inhibitor extracted from patent WO/2014043446 A1, compound example 1.
  • HY-101872
    GSK'872 Inhibitor 99.65%
    GSK'872 is a RIPK3 inhibitor, which binds RIP3 kinase domain with high affinity (IC50=1.8 nM,), and inhibits kinase activity (IC50=1.3 nM).
  • HY-101032
    RIPA-56 Inhibitor 99.86%
    RIPA-56 is a highly potent, selective, and metabolically stable inhibitor of receptor-interacting protein 1 (RIP1) with an IC50 of 13 nM.
  • HY-19761
    RIP2 kinase inhibitor 2 Inhibitor
    RIP2 kinase inhibitor 2 is a receptor interacting protein-2 (RIP2) kinase inhibitor extracted from patent WO/2014043437 A1, compound example 9.
  • HY-100131
    GSK'481 Inhibitor >98.0%
    GSK'481 can inhibit RIP1 WT S166 phosphorylation in human vs mouse plasmids overexpressed in HEK293T cells.