1. Apoptosis
  2. RIP kinase
  3. Necrostatin 2 racemate

Necrostatin 2 racemate (Synonyms: Necrostatin-2 racemate)

Cat. No.: HY-14622A Purity: 99.10%
Handling Instructions

Necrostatin 2 racemate is a potent necroptosis inhibitor, acts as a RIPK1 inhibitor lacking the IDO-targeting effect.

For research use only. We do not sell to patients.

Necrostatin 2 racemate Chemical Structure

Necrostatin 2 racemate Chemical Structure

CAS No. : 852391-15-2

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 257 In-stock
Estimated Time of Arrival: December 31
1 mg USD 84 In-stock
Estimated Time of Arrival: December 31
5 mg USD 240 In-stock
Estimated Time of Arrival: December 31
10 mg USD 432 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1080 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Other Forms of Necrostatin 2 racemate:

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Description

Necrostatin 2 racemate is a potent necroptosis inhibitor, acts as a RIPK1 inhibitor lacking the IDO-targeting effect. Target: RIPK1 Necrostatin 2 racemate is a potent in vitro necroptosis inhibitors (exemplified by 1, EC50-0.05 uM) that also were efficacious in an animal model of ischemic stroke. Many Necroptosis inhibitor derivatives are designed for researchers. Necroptosis is a regulated caspase-independent cell death mechanism that results in morphological features resembling necrosis. It can be induced in a FADD-deficient variant of human Jurkat T cells treated with TNF-a. 5-(1H-Indol-3-ylmethyl)-2-thiohydantoins and 5-(1H-indol-3-ylmethyl)hydantoins were found to be potent necroptosis inhibitors (called necrostatins).

Molecular Weight

277.71

Formula

C₁₃H₁₂ClN₃O₂

CAS No.

852391-15-2

SMILES

ClC1=C2C(C(CC3C(N(C)C(N3)=O)=O)=CN2)=CC=C1

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 50 mg/mL (180.04 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6009 mL 18.0044 mL 36.0088 mL
5 mM 0.7202 mL 3.6009 mL 7.2018 mL
10 mM 0.3601 mL 1.8004 mL 3.6009 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 3 mg/mL (10.80 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 3 mg/mL (10.80 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 3 mg/mL (10.80 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Necrostatin 2 racemate
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