TLR4/CD284
TLR4, designated CD284 in the CD nomenclature, is the pattern-recognition receptor for lipopolysaccharide from Gram-negative bacteria. Ligand engagement recruits the co-receptors MD-2 and CD14 and triggers both MyD88-dependent NF-κB signaling and the TRIF-driven interferon pathway. Structurally, it comprises an extracellular leucine-rich repeat domain, a single transmembrane helix and an intracellular Toll/IL-1 receptor (TIR) motif. Although best studied on myeloid cells, TLR4 is also displayed on T lymphocytes, where it can costimulate activation and proliferation independently of antigen receptor signaling. Dysregulated TLR4 signaling is implicated in septic shock, chronic inflammation and atherosclerosis, making the receptor a long-standing target for sepsis and vaccine-adjuvant research.
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TLR4/CD284 Recombinant Proteins (2)
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Inhibitors & Agonists (115)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
