Cystatin B
Cystatin B, or stefin B, is a ubiquitously expressed type 1 intracellular cystatin and one of the major cytosolic inhibitors of cathepsins B, H, and L, dampening protease activity that leaks from lysosomes. Beyond protease inhibition, it interacts with cellular partners involved in apoptosis and has been proposed to modulate caspase activity. Expansions of a dodecamer repeat in the CSTB promoter cause progressive myoclonus epilepsy of Unverricht-Lundborg type (EPM1), linking cystatin B directly to neurodegeneration. Recombinant cystatin B serves studies of cathepsin regulation, EPM1 disease mechanisms, and neuronal proteostasis. Unlike type 2 cystatins, cystatin B lacks glycosylation and functions chiefly in the cytosol.
-
Cystatin B Recombinant Proteins (2)
- Species:
- Source:
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
