1. Autophagy
  2. Mitophagy

Mitophagy

Mitophagy is the selective degradation of mitochondria by autophagy.

Mitochondria are essential organelles that regulate cellular energy homeostasis and cell death. The removal of damaged mitochondria through autophagy, a process called mitophagy, is thus critical for maintaining proper cellular functions. Indeed, mitophagy has been recently proposed to play critical roles in terminal differentiation of red blood cells, paternal mitochondrial degradation, neurodegenerative diseases, and ischemia or drug-induced tissue injury.

Autophagy and mitophagy are important cellular processes that are responsible for breaking down cellular contents, preserving energy and safeguarding against accumulation of damaged and aggregated biomolecules.

Mitophagy Related Products (59):

Cat. No. Product Name Effect Purity
  • HY-19312
    3-Methyladenine Inhibitor 99.84%
    3-Methyladenine is a potent inhibitor of autophagy and PI3K, blocking autophagy through its effect on PI3K, with IC50s of 25 μM and 60 μM for Vps34 and PI3Kγ, respectively.
  • HY-10256
    SB 203580 Activator 99.54%
    SB 203580 is a p38 MAPK inhibitor with IC50 of 0.3-0.5 μM, also blocks PKB phosphorylation with IC50 of 3-5 μM.
  • HY-10162
    Olaparib Activator 99.71%
    Olaparib is a potent PARP inhibitor with IC50 of 5 and 1 nM for PARP-1 and PARP-2, respectively.
  • HY-15142
    Doxorubicin hydrochloride Activator 99.47%
    Doxorubicin hydrochloride is a Topoisomerase II (Top2) catalytic inhibitor, also is a broad spectrum antibiotic used in the treatment of cancers, with IC50 of 374 nM for Hela cells.
  • HY-12031
    U0126 Inhibitor 98.06%
    U0126 is a non-ATP competitive MEK inhibitor, with IC50 of 70 nM and 60 nM for MEK1 and MEK2, respectively.
  • HY-B0969
    Cresol Activator >98.0%
    Cresol is organic compound,is a widely occurring natural and manufactured group of aromatic organic compounds.
  • HY-17471A
    Metformin hydrochloride Activator 99.98%
    Metformin (hydrochloride) is a first-line drug for the treatment of type 2 diabetes and there is increasing evidence of a potential efficacy of this agent as an anti-cancer drug.
  • HY-13417
    AICAR Inhibitor 99.90%
    AICAR is an activator of AMP-activated protein kinase (AMPK), down-regulates the insulin receptor expression in HepG2 cells.
  • HY-16592
    Brefeldin A Inhibitor 99.45%
    Brefeldin A is an alternative autophagy inhibitor, and also increases CRISPR/Cas9-mediated editing frequencies.
  • HY-14648
    Dexamethasone Activator 99.70%
    Dexamethasone is a glucocorticoid receptor agonist.
  • HY-50856
    Ruxolitinib Activator 99.97%
    Ruxolitinib is the first potent, selective JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM in cell-free assays, and has > 130-fold selectivity for JAK1/2 versus JAK3.
  • HY-10221
    Vorinostat Activator 99.90%
    Vorinostat is a potent and orally available inhibitor of HDAC1, HDAC2 and HDAC3 (Class I), HDAC7 (Class II) and Class IV (HDAC11), with ID50 values of 10 nM and 20 nM for HDAC1/3, respectively.
  • HY-13629
    Etoposide Activator 99.84%
    Etoposide is a topoisomerase II inhibitor, inhibiting DNA synthesis.
  • HY-16561
    Resveratrol Activator 98.90%
    Resveratrol is one of the numerous polyphenolic compounds found in several vegetal sources, has a wide spectrum of targets with IC50 of 0.8, 1, 3.3 and 5 μM for adenylyl cyclase, IKKβ, DNA polymerase α and δ, respectively.
  • HY-10211
    17-AAG Inhibitor 99.03%
    17-AAG is a potent HSP90 inhibitor with IC50 of 5 nM, having a 100-fold higher binding affinity for HSP90 derived from tumour cells than HSP90 from normal cells.
  • HY-B0988
    Deferoxamine mesylate Activator >98.0%
    Deferoxamine mesylate is an iron chelator, and effectively reduces oxidative stress and neuronal death.
  • HY-10255A
    Sunitinib Activator 99.66%
    Sunitinib is a potent tyrosine kinase inhibitor targeting VEGFR2 and PDGFRβ with IC50 of 80 nM and 2 nM, respectively.
  • HY-50858
    Ruxolitinib phosphate Activator 99.89%
    Ruxolitinib (phosphate) is the first potent JAK1/2 inhibitor with IC50 values of 3.3 nM/2.8 nM, more than 130-fold selectivity for JAK1/2 versus JAK3.
  • HY-15597
    Salinomycin Modulator >98.0%
    Salinomycin is an inhibitor of Wnt/β-catenin signaling, which acts on the Wnt/Fzd/LRP complex. Salinomycin strongly suppresses Wnt1-stimulated reporter activity with an IC50 of 163 nM, and reduces β-catenin levels.
  • HY-50907
    ABT-737 Activator 98.38%
    ABT-737 is a BH3 mimetic inhibitor of Bcl-xLBcl-2 and Bcl-w with EC50 of 78.7 nM, 30.3 nM and 197.8 nM in cell-free assays, respectively, and shows no inhibition against Mcl-1, Bcl-B or Bfl-1.
Isoform Specific Products

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