1. Cell Cycle/DNA Damage
    Epigenetics
  2. PARP
  3. PARP2 Inhibitors

PARP2 Inhibitors

PARP

PARP1

PARP2

PARP3

PARP4

TNKS1/PARP5A

TNKS2/PARP5B

PARP10

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Sorry. There is currently no product that acts on isoform PARP2 together.

Please try each isoform separately.

PARP2 Specific Inhibitors
Product Name PARP2 PARP PARP1 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP10 PARP2 Selectivity Purity
PARP-2-IN-1
PARP-2, IC50: 11.5 nM
              Selective Inhibitor
UPF 1069
PARP-2, IC50: 0.3 μM
 
PARP-1, IC50: 8 μM
          Selective Inhibitor 98.88%
Olaparib
PARP-2, IC50: 1 nM
 
PARP-1, IC50: 5 nM
   
tankyrase-1, IC50: 1.5 μM
    Pan Inhibitor 99.98%
Talazoparib
PARP2, Ki: 0.87 nM
 
PARP1, Ki: 1.2 nM
          Pan Inhibitor 99.83%
XAV-939
ARTD2, IC50: 479 nM
 
ARTD1, IC50: 5500 nM
   
TNKS1, IC50: 5 nM
TNKS2, IC50: 2 nM
  Pan Inhibitor 98.04%
Niraparib
PARP-2, IC50: 2.1 nM
 
PARP-1, IC50: 3.8 nM
PARP-3, IC50: 1300 nM
V-PARP, IC50: 330 nM
TANK-1, IC50: 570 nM
    Pan Inhibitor 99.93%
Veliparib
PARP-2, Ki: 2.9 nM
 
PARP-1, Ki: 5.2 nM
          Pan Inhibitor >98.0%
Niraparib tosylate
PARP-2, IC50: 2.1 nM
 
PARP-1, IC50: 3.8 nM
PARP-3, IC50: 1300 nM
V-PARP, IC50: 330 nM
TANK-1, IC50: 570 nM
    Pan Inhibitor 99.52%
PJ34
PARP-2, IC50: 86 nM
PARP, IC50: 110 nM
PARP-1, IC50: 110 nM
          Pan Inhibitor >98.0%
NMS-P118
PARP-2, Kd: 1390 nM
 
PARP-1, Kd: 9 nM
          Pan Inhibitor 99.08%
AZD-2461
PARP2, IC50: 2 nM
 
PARP1, IC50: 5 nM
PARP3, IC50: 200 nM
        Pan Inhibitor 98.39%
A-966492
PARP-2, Ki: 1.5 nM
 
PARP-1, Ki: 1 nM
          Pan Inhibitor 98.59%
NVP-TNKS656
PARP2, IC50: 32 μM
         
TNKS2, IC50: 6 nM
  Pan Inhibitor 99.14%
MN-64
ARTD2, IC50: 39.4 μM
 
ARTD1, IC50: 19.1 μM
   
TNKS1, IC50: 6 nM
TNKS2, IC50: 72 nM
  Pan Inhibitor 98.22%
ME0328
ARTD2/PARP2, IC50: 10.8 μM
 
ARTD1/PARP1, IC50: 6.3 μM
ARTD3/PARP3, IC50: 0.89 μM
 
ARTD5/TNKS1, IC50: 47.3 μM
ARTD6/TNKS2, IC50: 34.3 μM
ARTD10/PARP10, IC50: 71.3 μM
Pan Inhibitor 99.34%
Niraparib hydrochloride
PARP-2, IC50: 2.1 nM
 
PARP-1, IC50: 3.8 nM
PARP-3, IC50: 1300 nM
V-PARP, IC50: 330 nM
TANK-1, IC50: 570 nM
    Pan Inhibitor