2360853-16-1
2360853-16-1
Chemical Structure
RBN-3143
- CAS. Nr.: 2360853-16-1
- Formula:C22H28FN3O4S
- Molecular Weight:449.54
IUPAC Name: 7-((1-acetylpiperidin-4-yl)methoxy)-5-fluoro-2-(((tetrahydro-2H-pyran-4-yl)thio)methyl)quinazolin-4(3H)-one
InChIKey: LLXIEISWIFSUBQ-UHFFFAOYSA-N
SMILES: O=C1NC(CSC2CCOCC2)=NC3=CC(OCC4CCN(CC4)C(C)=O)=CC(F)=C13
Biological Activity: RBN-3143 is a potent and NAD+-competitive catalytic PARP14 inhibitor with an IC50 value of 4 nM. RBN-3143 inhibits PARP14-mediated ADP-ribosylation and stabilizes PARP14 in cell lines. RBN-3143 can be used in research of lung inflammation[1].
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RBN-3143 | 99.29% | RBN-3143 is a potent and NAD+-competitive catalytic PARP14 inhibitor with an IC50 value of 4 nM. RBN-3143 inhibits PARP14-mediated ADP-ribosylation and stabilizes PARP14 in cell lines. RBN-3143 can be used in research of lung inflammation. | ||||||||||||||||||||
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References
Keywords
