2. Cell Cycle/DNA Damage
    Epigenetics
  3. PARP
  4. RBN-3143

RBN-3143 

Cat. No.: HY-150207 Purity: 99.24%
COA Handling Instructions

RBN-3143 is a potent and NAD+-competitive catalytic PARP14 inhibitor with an IC50 value of 4 nM. RBN-3143 inhibits PARP14-mediated ADP-ribosylation and stabilizes PARP14 in cell lines. RBN-3143 can be used in research of lung inflammation.

For research use only. We do not sell to patients.

RBN-3143 Chemical Structure

RBN-3143 Chemical Structure

CAS No. : 2360853-16-1

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 286 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 286 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 260 In-stock
Estimated Time of Arrival: December 31
10 mg USD 380 In-stock
Estimated Time of Arrival: December 31
25 mg USD 800 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1280 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2100 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

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Description

RBN-3143 is a potent and NAD+-competitive catalytic PARP14 inhibitor with an IC50 value of 4 nM. RBN-3143 inhibits PARP14-mediated ADP-ribosylation and stabilizes PARP14 in cell lines. RBN-3143 can be used in research of lung inflammation[1].

IC50 & Target[1]

PARP14

4 nM (IC50)

PARP10

1600 nM (IC50)

PARP15

4200 nM (IC50)

PARP4

42700 nM (IC50)

PARP3

>100000 nM (IC50)

PARP2

>100000 nM (IC50)

PARP1

>100000 nM (IC50)

In Vivo

RBN-3143 (5 μg; intranasal administration) can improve steroid-resistant asthma mouse models[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mouse of asthma models[1]
Dosage: 5 ug
Administration: Intranasal administration
Result: Suppressed the accumulation of alarmins TSLP, IL-33, and IL-25.
Molecular Weight

449.54

Appearance

Solid

Formula

C22H28FN3O4S
CAS No.
SMILES

O=C1NC(CSC2CCOCC2)=NC3=CC(OCC4CCN(CC4)C(C)=O)=CC(F)=C13
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 12.5 mg/mL (27.81 mM; ultrasonic and warming and heat to 80°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2245 mL 11.1225 mL 22.2450 mL
5 mM 0.4449 mL 2.2245 mL 4.4490 mL
10 mM 0.2224 mL 1.1122 mL 2.2245 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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Keywords:

RBN-31432360853-16-1RBN3143RBN 3143PARPpoly ADP ribose polymeraseADP-ribosylationinflammationasthmaTSLPIL-33IL-25Inhibitorinhibitorinhibit

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