1. Signaling Pathways
  2. Cell Cycle/DNA Damage
    Epigenetics
  3. PARP
  4. PARP Inhibitors

PARP Inhibitors

PARP

PARP1

PARP2

PARP3

PARP4

TNKS1/PARP5A

TNKS2/PARP5B

PARP7

PARP10

PARP14

PARP15

PARP12

PARP16

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Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.

PARP Inducers, Degraders, Inhibitors & Activators
Product Name PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16 Purity
Olaparib  
PARP-1, IC50: 5 nM
PARP-2, IC50: 1 nM
   
tankyrase-1, IC50: 1.5 μM
              99.98%
XAV-939  
ARTD1, IC50: 5500 nM
ARTD2, IC50: 479 nM
   
TNKS1, IC50: 5 nM
TNKS2, IC50: 2 nM
            99.91%
Talazoparib  
PARP1, Ki: 1.2 nM
PARP2, Ki: 0.87 nM
                    99.89%
Niraparib  
PARP-1, IC50: 3.8 nM
PARP-2, IC50: 2.1 nM
PARP-3, IC50: 1300 nM
V-PARP, IC50: 330 nM
TANK-1, IC50: 570 nM
              99.96%
Saruparib  
PARP1, IC50: 3 nM
PARP2, IC50: 1400 nM
                    99.79%
PARP7-IN-15              
PARP7, IC50: 0.56 nM
         
PARP7-IN-16  
PARP-1, IC50: 0.94 nM
PARP-2, IC50: 0.87 nM
       
PARP-7, IC50: 0.21 nM
         
Rucaparib  
PARP-1, Ki: 1.4 nM
                      99.80%
Veliparib  
PARP-1, Ki: 5.2 nM
PARP-2, Ki: 2.9 nM
                    99.92%
PJ34
PARP, IC50: 110 nM
PARP-1, IC50: 110 nM
PARP-2, IC50: 86 nM
                    98.01%
Chlorin e6  
PARP-1
                     
RBN-2397              
PARP-7, IC50: 3 nM
PARP-7, Kd: 1 nM
          99.86%
Pamiparib
PARP
                        99.97%
Niraparib tosylate  
PARP-1, IC50: 3.8 nM
PARP-2, IC50: 2.1 nM
PARP-3, IC50: 1300 nM
V-PARP, IC50: 330 nM
TANK-1, IC50: 570 nM
              99.99%
Fluzoparib  
PARP-1, IC50: 1.46±0.72  nM
                      99.85%
Dehydrocorydaline
PARP
                        99.77%
RBN012759        
PARP4, IC50: 10 μM
   
PARP7, IC50: 4 μM
PARP10, IC50: 1 μM
PARP14, IC50: <3 nM
      99.80%
3-Aminobenzamide
PARP, IC50: 50 nM
                        99.99%
G007-LK          
TNKS1, IC50: 46 nM
TNKS2, IC50: 25 nM
            99.42%
AG14361  
PARP-1, Ki: 0.5 nM
                      99.44%
Niraparib hydrochloride  
PARP-1, IC50: 3.8 nM
PARP-2, IC50: 2.1 nM
PARP-3, IC50: 1300 nM
V-PARP, IC50: 330 nM
TANK-1, IC50: 570 nM
              99.76%
PJ34 hydrochloride
PARP, IC50: 110 nM
PARP-1, IC50: 110 nM
PARP-2, IC50: 86 nM
                    99.91%
NVP-TNKS656    
PARP2, IC50: 32 μM
     
TNKS2, IC50: 6 nM
            99.31%
AZD-2461  
PARP1, IC50: 5 nM
PARP2, IC50: 2 nM
PARP3, IC50: 200 nM
                  99.88%
Rucaparib monocamsylate  
PARP-1, Ki: 1.4 nM
                      99.82%
Iniparib  
PARP1
                      99.82%
SK-575  
PARP1, IC50: 2.30 nM
                      99.51%
Paris saponin VII  
PARP-1
                      99.13%
Venadaparib  
PARP1, IC50: 1.4 nM
PARP2, IC50: 1 nM
                    98.03%
RBN-3143  
PARP1, IC50: >100000 nM
PARP2, IC50: >100000 nM
PARP3, IC50: >100000 nM
PARP4, IC50: 42700 nM
     
PARP10, IC50: 1600 nM
PARP14, IC50: 4 nM
PARP15, IC50: 4200 nM
    99.24%
Rucaparib phosphate  
PARP-1, Ki: 1.4 nM
                      99.76%
Veliparib dihydrochloride  
PARP-1, Ki: 5.2 nM
PARP-2, Ki: 2.9 nM
                    99.96%
Peiminine  
PARP-1
                      99.94%
Stenoparib  
PARP1, IC50: 2 nM
PARP2, IC50: 1 nM
   
TNKS1, IC50: 50 nM
TNKS2, IC50: 50 nM
            ≥98.0%
BGP-15
PARP, IC50: 120 μM
                        ≥98.0%
iRucaparib-AP6  
PARP1, DC50: 82 nM
                      98.04%
UPF 1069  
PARP-1, IC50: 8 μM
PARP-2, IC50: 0.3 μM
                    99.10%
Triclabendazole
PARP
                        98.72%
ME0328  
ARTD1/PARP1, IC50: 6.3 μM
ARTD2/PARP2, IC50: 10.8 μM
ARTD3/PARP3, IC50: 0.89 μM
 
ARTD5/TNKS1, IC50: 47.3 μM
ARTD6/TNKS2, IC50: 34.3 μM
 
ARTD10/PARP10, IC50: 71.3 μM
        99.87%
WIKI4            
TNKS2, IC50: 26 nM
            99.93%
JW 55          
TNKS1, IC50: 1.9 μM
TNKS2, IC50: 0.83 μM
            99.94%
RK-287107          
tankyrase-1, IC50: 14.3 nM
tankyrase-2, IC50: 10.6 nM
            99.81%
OUL35                
ARTD10/PARP10, IC50: 329 nM
        99.84%
Mefuparib hydrochloride  
PARP1, IC50: 3.2 nM
PARP2, IC50: 1.9 nM
   
TNKS1, IC50: 1.6 μM
TNKS2, IC50: 1.3 μM
            98.94%
INO-1001
PARP
                        98.19%
NMS-P118  
PARP-1, Kd: 9 nM
PARP-2, Kd: 1390 nM
                    99.78%
PARP14 inhibitor H10                  
PARP14, IC50: 490 nM
      98.04%
PARP1-IN-5 dihydrochloride  
PARP-1, IC50: 14.7 nM
PARP-2, IC50: 0.9 μM
                   
5,​7,​4'-​Trimethoxyflavone
PARP
                        99.65%
Niraparib (R-enantiomer)  
PARP-1, IC50: 2.4 nM
                      99.69%
GeA-69                  
PARP14, Kd: 2.1 μM
      99.97%
K-756          
TNKS1, IC50: 31 nM
TNKS2, IC50: 36 nM
            99.76%
BYK204165  
hPARP-1, pIC50: 7.35
mPARP-2, pIC50: 5.38
                    98.66%
A-966492  
PARP-1, Ki: 1 nM
PARP-2, Ki: 1.5 nM
                    99.95%
OM-153          
TNKS1, IC50: 13 nM
TNKS2, IC50: 2 nM
            99.59%
MN-64  
ARTD1, IC50: 19.1 μM
ARTD2, IC50: 39.4 μM
   
TNKS1, IC50: 6 nM
TNKS2, IC50: 72 nM
            99.73%
PARP10/15-IN-1                
PARP10, IC50: 160 nM
 
PARP15, IC50: 370 nM
   
(8R,9S)-Talazoparib  
PARP-1, IC50: 144 nM
                      98.36%
Simmiparib  
PARP1, IC50: 0.74 nM
PARP2, IC50: 0.22 nM
                    99.51%
NMS-P515  
PARP-1, Kd: 16 nM
PARP-1, IC50: 27 nM (in Hela cells)
                      98.18%
1,5-Isoquinolinediol
PARP, IC50: 0.18-0.37 μM
                        99.33%
PARP10/15-IN-3                
PARP10, IC50: 0.14 μM
 
PARP15, IC50: 0.40 μM
    99.98%
5,7-Dihydroxychromone
PARP
                        99.98%
Niraparib tosylate hydrate  
PARP-1, IC50: 3.8 nM
PARP-2, IC50: 2.1 nM
PARP-3, IC50: 1300 nM
V-PARP, IC50: 330 nM
TANK-1, IC50: 570 nM
              99.97%
MSC2504877  
PARP1, IC50: 0.54 μM
                      98.50%
OUL232  
PARP1, IC50: 15 μM
PARP2, IC50: 10 μM
PARP3, IC50: 50 μM
PARP4, IC50: 11 μM
TNKS1, IC50: 5.4 μM
TNKS2, IC50: 10 μM
PARP7, IC50: 83 nM
PARP10, IC50: 7.8 nM
PARP14, IC50: 300 nM
PARP15, IC50: 56 nM
    99.82%
DB008                        
PARP16, IC50: 0.27 μM
98.78%
ART-IN-1    
PARP2, IC50: 19 μM
     
TNKS2, IC50: 22 μM
 
PARP10, IC50: 2.4 μM
PARP14, IC50: >100 μM
PARP15, IC50: 1.1 μM
    98.91%
PARP10/15-IN-2                
PARP10, IC50: 0.15 μM
 
PARP15, IC50: 0.37 μM
    99.00%
E7016
PARP
                        98.46%
TIQ-A    
PARP2, IC50: 210 nM
     
TNKS2, IC50: 24 nM
 
PARP10, IC50: >10 μM
PARP14, IC50: >10 μM
PARP15, IC50: 230 nM
    99.65%
PARP1-IN-11  
PARP1, IC50: 0.082 μM
                      98.58%
PROTAC PARP1 degrader  
PARP1
                     
PARP/PI3K-IN-1  
PARP-1, pIC50: 8.22
PARP-2, pIC50: 8.44
                    99.43%
Verminoside  
PARP-1
                      ≥98.0%
DR2313  
PARP-1, IC50: 0.20 μM
PARP-2, IC50: 0.24 μM
                    98.70%
PARP-1-IN-2  
PARP-1, IC50: 149 ± 11.0 nM
                      98.80%
PARP10-IN-3  
human PARP1, IC50: >100 μM
human PARP2, IC50: 1.7 μM
human PARP3, IC50: >100 μM
human PARP4, IC50: 7 μM
human TNKS1, IC50: 21 μM
human TNKS2, IC50: 6.5 μM
 
human PARP10, IC50: 480 nM
human PARP14, IC50: 41 μM
human PARP15, IC50: 1.7 μM
human PARP12, IC50: >10 μM
human PARP16, IC50: >10 μM
98.89%
Rucaparib tartrate  
PARP-1, Ki: 1.4 nM
                     
Rucaparib camsylate  
PARP-1, Ki: 1.4 nM
                     
PARP1-IN-5  
PARP-1, IC50: 14.7 nM
PARP-2, IC50: 0.9 μM
                   
Rucaparib acetate  
PARP-1, Ki: 1.4 nM
                     
Venadaparib hydrochloride  
PARP1, IC50: 1.4 nM
PARP2, IC50: 1 nM
                   
PARP-2-IN-1    
PARP-2, IC50: 11.5 nM
                   
BPA-B9
PARP
                       
PARP7-IN-17              
PARP7
         
Rucaparib hydrochloride  
PARP-1, Ki: 1.4 nM
                     
PARP1-IN-9  
PARP1, IC50: 30.51 nM
                     
PARP-2-IN-3    
PARP-2, IC50: 0.07 μM
                   
EB-47  
ARTD1/PARP1, IC50: 45 nM
                     
OM-1700          
TNKS1, IC50: 127 nM
TNKS2, IC50: 14 nM
           
ARTD10/PARP10-IN-1  
ARTD1/PARP1, IC50: 4.4 μM
           
ARTD10/PARP10, IC50: 0.8 μM
ARTD8/PARP14, IC50: 1.6 μM
ARTD7/PARP15, IC50: 1.7 μM
   
PARP-1-IN-3  
PARP-1, IC50: 0.25 nM
PARP-2, IC50: 2.34 nM
                    99.30%
PARP1/BRD4-IN-1  
PARP1, IC50: 49 nM
                     
TC-E 5001          
TNKS1, Ki: 79 nM
TNKS2, Ki: 28 nM
           
PARPYnD  
PARP1
PARP2
                   
PARP1-IN-8  
PARP-1, IC50: 97 nM
                      99.29%
PARP7-IN-12              
PARP7, IC50: 7.836 nM
         
PARP/EZH2-IN-2  
PARP1, IC50: 6.89 ± 0.7 nM
                     
PARP1/BRD4-IN-2  
PARP1, IC50: 197 nM
                     
PARP1-IN-14  
PARP1, IC50: 0.6 ± 0.1 nM
                     
Tankyrase-IN-4          
TNKS1, IC50: 0.8 nM
             
Anticancer agent 64
PARP
                       
Aviculin
PARP
                       
Tankyrase-IN-3          
TNKS1, IC50: 22 nM
             
KU-0058948 hydrochloride  
PARP-1, IC50: 3.4 nM
                     
PARP1-IN-18  
PARP1, IC50: 2.7 nM
                     
PARP10-IN-2  
human PARP1, IC50: >100 μM
human PARP2, IC50: 27 μM
human PARP3, IC50: >100 μM
human PARP4, IC50: >100 μM
human TNKS1, IC50: >100 μM
human TNKS2, IC50: >100 μM
 
human PARP10, IC50: 3.64 μM
human PARP14, IC50: >100 μM
human PARP15, IC50: 11 μM
human PARP12, IC50: >10 μM
human PARP16, IC50: >10 μM
98.02%
PARP/EZH2-IN-1  
PARP-1, IC50: 6.87 nM
                     
PARP-2/1-IN-2  
PARP1, Ki: 5 nM
PARP2, Ki: 2 nM
                   
OUL245  
PARP-1, IC50: 570 nM
PARP2, IC50: 44 nM
PARP3, IC50: 8.8 μM
PARP4, IC50: 6.0 μM
TNKS1, IC50: 1.6 μM
TNKS2, IC50: 370 μM
 
PARP10, IC50: 2.9 μM
PARP14, IC50: 6.7 μM
PARP15, IC50: 2.0 μM
   
Anticancer agent 43  
PARP1
                      98.58%
PARP1-IN-10  
PARP1, IC50: 50.62 nM ([1])
                     
SK-575-NEG  
PARP-1, IC50: 2.64 nM
                     
PARP1/2/TNKS1/2-IN-1  
PARP-1, IC50: 0.25 nM
PARP-2, IC50: 1.2 nM
   
TNKS1, IC50: 13.5 nM
TNKS2, IC50: 4.15 nM
           
PARP-1/HDAC-IN-1  
PARP-1, IC50: 68.90 nM
                     
PARP1-IN-17  
PARP-1
                     
ARTD10/PARP10-IN-2  
ARTD1/PARP1, IC50: 9.7 μM
           
ARTD10/PARP10, IC50: 2.0 μM
ARTD8/PARP14, IC50: >20 μM
ARTD7/PARP15, IC50: >20 μM
   
YCH1899  
PARP-1, IC50: <0.001 nM
PARP-2, IC50: <0.001 nM
PARP3, IC50: 1.1 nM
PARP4, IC50: 1.0 nM
TNKS1, EC50: 3.8 nM
TNKS2, IC50: 12.4 nM
PARP-7, IC50: 7.3 nM
ARTD10/PARP10, IC50: 10.8 nM
PARP14, IC50: 35.914 μM
PARP15, IC50: 51.623 nM
human PARP12, IC50: 14.1 nM
 
PARP1-IN-12  
PARP-1, IC50: 2.99 nM
                     
CEP-9722  
PARP-1, IC50: 20 nM
PARP-2, IC50: 6 nM
                   
WD2000-012547  
PARP-1, pKi: 8.221