IL-13
Interleukin-13 (IL-13) is a central Th2 effector cytokine of the IL-4/IL-13 family, secreted by activated Th2 cells, group 2 innate lymphoid cells, mast cells, eosinophils and NKT cells. It shares many biological activities with IL-4 through the IL-4Rα/IL-13Rα1 receptor complex, activating STAT6, STAT3 and SOCS1 pathways. IL-13 is the key driver of allergic inflammation and airway remodeling: it induces IgE class switching, goblet cell metaplasia, mucus hypersecretion, airway hyperresponsiveness, periostin production and fibrosis, but unlike IL-4 it cannot signal through the common gamma chain and exerts weaker effects on T-cell proliferation. IL-13Rα2 acts as a decoy receptor and profibrotic mediator. Anti-IL-13 antibodies such as lebrikizumab and tralokinumab are used for atopic dermatitis and asthma.
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IL-13 Recombinant Proteins (19)
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Inhibitors & Agonists (58)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- 1
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
