Signaling Pathway

G-quadruplex

G-quadruplex

Related Products

PDF File 0.21MB

G-quadruplexes (G-tetrads or G4-DNA) are nucleic acid sequences that are rich in guanine and are capable of forming a four-stranded structure. Four guanine bases can associate through Hoogsteen hydrogen bonding to form a square planar structure called a guanine tetrad, and two or more guanine tetrads can stack on top of each other to form a G-quadruplex. The quadruplex structure is further stabilized by the presence of a cation, especially potassium, which sits in a central channel between each pair of tetrads.They can be formed of DNA, RNA, LNA, and PNA, and may be intramolecular, bimolecular or tetramolecular. Depending on the direction of the strands or parts of a strand that form the tetrads, structures may be described as parallel or antiparallel.

G-quadruplex Inhibitors & Modulators (4)

Product Name Catalog No. Brief Description
360A

HY-15595

360A is a strong affinity and selectivity inhibitor of G-quadruplex structures.

360A iodide

HY-15595A

360A is a strong affinity and selectivity inhibitor of G-quadruplex structures.

Pyridostatin

HY-15176

Pyridostatin(RR-82) is a G-quadruplex-interacting drug which can promote growth arrest in human cancer cells by inducing replication- and transcription-dependent DNA damage.

Pyridostatin hydrochloride

HY-15176A

Pyridostatin(RR-82) Hcl is a G-quadruplex-interacting drug which can promote growth arrest in human cancer cells by inducing replication- and transcription-dependent DNA damage.