1. Cell Cycle/DNA Damage
  2. G-quadruplex

G-quadruplex

G-quadruplexes (G-tetrads or G4-DNA) are nucleic acid sequences that are rich in guanine and are capable of forming a four-stranded structure. Four guanine bases can associate through Hoogsteen hydrogen bonding to form a square planar structure called a guanine tetrad, and two or more guanine tetrads can stack on top of each other to form a G-quadruplex. The quadruplex structure is further stabilized by the presence of a cation, especially potassium, which sits in a central channel between each pair of tetrads.They can be formed of DNA, RNA, LNA, and PNA, and may be intramolecular, bimolecular or tetramolecular. Depending on the direction of the strands or parts of a strand that form the tetrads, structures may be described as parallel or antiparallel.

G-quadruplex Related Products (6):

Cat. No. Product Name Effect Purity
  • HY-16291
    APTO-253 Activator 99.16%
    APTO-253 is an inducer of Kruppel-like factor 4 (KLF4), and also stabilizes Gquadruplex, with anti-proliferative activity.
  • HY-15176A
    Pyridostatin hydrochloride Activator >98.0%
    Pyridostatin hydrochloride is a G-quadruplexe stabilizer, with a Kd of 490 nM.
  • HY-15595A
    360A iodide Activator >98.0%
    360A iodide is a selective stabilizer of G-quadruplex, and also inhibits telomerase activity with an IC50 of 300 nM for telomerase in TRAP-G4 assay.
  • HY-15594A
    Phen-DC3 Trifluoromethanesulfonate Inhibitor 98.66%
    Phen-DC3 Trifluoromethanesulfonate is a G-quadruplex (G4) specific ligand which can inhibit FANCJ and DinG helicases with IC50s of 65±6 and 50±10 nM, respectively.
  • HY-15176
    Pyridostatin Activator
    Pyridostatin is a G-quadruplexe stabilizer, with a Kd of 490 nM.
  • HY-15595
    360A Activator
    360A is a selective stabilizer of G-quadruplex, and also inhibits telomerase activity with an IC50 of 300 nM for telomerase in TRAP-G4 assay.
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