627810-06-4
Chemical Structure
BMVC
- CAS No.: 627810-06-4
- Formula:C28H25I2N3
- Molecular Weight:657.33
IUPAC Name: 4,4'-((1E,1'E)-(9H-carbazole-3,6-diyl)bis(ethene-2,1-diyl))bis(1-methylpyridin-1-ium) iodide
InChIKey: FKOQWAUFKGFWLH-UHFFFAOYSA-M
SMILES: C[N+]1=CC=C(/C=C/C2=CC3=C(C=C2)NC4=C3C=C(/C=C/C5=CC=[N+](C)C=C5)C=C4)C=C1.[I-].[I-]
Biological Activity: BMVC is a potent G-quadruplex (G4) stabilizer and a selective telomerase inhibitor with an IC50 of ~0.2 μM. BMVC inhibits Taq DNA polymerase with an IC50 of ~2.5 μM. BMVC increases the melting temperature of G4 structure of telomere and accelerates telomere length shortening. Anticancer activities[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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BMVC | 98.40% | BMVC is a potent G-quadruplex (G4) stabilizer and a selective telomerase inhibitor with an IC50 of ~0.2 μM. BMVC inhibits Taq DNA polymerase with an IC50 of ~2.5 μM. BMVC increases the melting temperature of G4 structure of telomere and accelerates telomere length shortening. Anticancer activities. | ||||||||||||||||||||
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- [1]. Huang FC, et al. G-quadruplex stabilizer 3,6-bis(1-methyl-4-vinylpyridinium)carbazole diiodide induces accelerated senescence and inhibits tumorigenic properties in cancer cells. Mol Cancer Res. 2008 Jun;6(6):955-64. [Content Brief]
- [2]. Jen-Fei Chu, et al. A Novel Method for Screening G-quadruplex Stabilizers to Human Telomeres. Journal of the Chinese Chemical Society, 2011, 58, 296-300.
Keywords
