1. Cell Cycle/DNA Damage
  2. G-quadruplex
    Telomerase
    DNA/RNA Synthesis
  3. BMVC

BMVC 

Cat. No.: HY-135775
Handling Instructions

BMVC is a potent G-quadruplex (G4) stabilizer and a selective telomerase inhibitor with an IC50 of ~0.2 μM. BMVC inhibits Taq DNA polymerase with an IC50 of ~2.5 μM. BMVC increases the melting temperature of G4 structure of telomere and accelerates telomere length shortening. Anticancer activities.

For research use only. We do not sell to patients.

BMVC Chemical Structure

BMVC Chemical Structure

CAS No. : 627810-06-4

Size Stock
100 mg   Get quote  
250 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

BMVC is a potent G-quadruplex (G4) stabilizer and a selective telomerase inhibitor with an IC50 of ~0.2 μM. BMVC inhibits Taq DNA polymerase with an IC50 of ~2.5 μM. BMVC increases the melting temperature of G4 structure of telomere and accelerates telomere length shortening. Anticancer activities[1][2].

IC50 & Target

IC50: ~0.2 μM (Telomerase)[1]
G-quadruplex[1]
IC50: ~2.5 μM (Taq DNA polymerase)[1]

In Vitro

BMVC (0.5 μM; 0-18 days; H1299 cells) treatment markedly increases the percentage of sub-G1-phase cells after 18 days[1].
BMVC (0.5 μM; 0-18 days; H1299 cells) long-term treatment leads to ceasing of cell growth and eventually cell death through apoptosis. The long-term BMVC treatment induces senescence program in H1299 cells[1].
In BMVC-treated cancer cells, hallmarks of senescence, including morphologic changes, detection of senescence-associated β-galactosidase activity, and decreasesd bromodeoxyuridine incorporation, are detected. The BMVC-induced senescence phenotype is accompanied by progressive telomere shortening and detection of the DNA damage foci, indicating that BMVC caused telomere uncapping after long-term treatments[1].
BMVC also suppresses the tumor-related properties of cancer cells, including cell migration, colony-forming ability, and anchorage-independent growth[1].

Cell Cycle Analysis[1]

Cell Line: H1299 cells
Concentration: 0.5 μM
Incubation Time: 0 day, 6 days, 12 days, 18 days
Result: The percentage of sub-G1-phase cells was markedly increased after 18 days.

Apoptosis Analysis[1]

Cell Line: H1299 cells
Concentration: 0.5 μM
Incubation Time: 0 day, 6 days, 12 days, 18 days
Result: Increased apoptotic cells.
In Vivo

BMVC (1 mg/kg; intraperitoneal injection; every 3 day; BALB/cAnN.Cg-Foxn1nu/CrlNarl mice) treatment delays tumorigenic potential of cancer cells in vivo[1].

Animal Model: BALB/cAnN.Cg-Foxn1nu/CrlNarl mice injected with H1299 cells[1]
Dosage: 1 mg/kg
Administration: Intraperitoneal injection; every 3 day
Result: The growth rates of tumors in animals were significantly slower than that of control animals. The tumor cells of the mice were indeed entering apoptosis.
Molecular Weight

657.33

Formula

C₂₈H₂₅I₂N₃

CAS No.

627810-06-4

SMILES

C[N+]1=CC=C(/C=C/C2=CC3=C(C=C2)NC4=C3C=C(/C=C/C5=CC=[N+](C)C=C5)C=C4)C=C1.[I-].[I-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

BMVCG-quadruplexTelomeraseDNA/RNA SynthesisAnticancercarbazoleapoptosissenescenceβ-galactosidaseDNAdamagetelomeremigrationcolony-formingInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product name:
BMVC
Cat. No.:
HY-135775
Quantity:
MCE Japan Authorized Agent: