1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. Ser/Thr Protease

Ser/Thr Protease

Serine proteases are enzymes that cleave peptide bonds in proteins, in which serine serves as the nucleophilic amino acidat the active site. They are found ubiquitously in both eukaryotes and prokaryotes. Serine proteases fall into two broad categories based on their structure: chymotrypsin-like or subtilisin-like. In humans, serine proteases are responsible for co-ordinating various physiological functions, including digestion, immune response, blood coagulation and reproduction. Threnonine proteases are a family of proteolytic enzymes harbouring a threonine (Thr) residue within the active site. The prototype members of this class of enzymes are the catalytic subunits of the proteasome, however the acyltransferases convergently evolved the same active site geometry andmechanism.

Ser/Thr Protease Related Products (8):

Cat. No. Product Name Effect Purity
  • HY-100877
    GCN2-IN-1 Inhibitor >98.0%
    GCN2-IN-1 is a potent general control nonderepressible 2 kinase (GCN2) inhibitor with IC50s of <0.3 μM in the enzyme and cell assay.
  • HY-B0190A
    Nafamostat mesylate Inhibitor 99.97%
    Nafamostat mesylate, a synthetic serine protease inhibitor, is an anticoagulant. Nafamostat mesylate supresses T cell auto-reactivity by decreasing granzyme activity and CTL cytolysis.
  • HY-13255
    TAME Inhibitor 99.11%
    TAME is a serine protease inhibitor and can be also utilized as a substrate for the serine proteases trypsin, plasmin, and thrombin. TAME is an inhibitor of anaphase-promoting complex (APC), which binds to the APC and prevents its activation by Cdc20 and Cdh1.
  • HY-16511
    Upamostat Inhibitor >98.0%
    Upamostat is a serine protease inhibitor. Upamostat is the orally available prodrug of the WX-UK1, which is a urokinase plasminogen activator (uPA) inhibitor.
  • HY-13255A
    TAME hydrochloride Inhibitor 99.10%
    TAME hydrochloride is a serine protease inhibitor and can be also utilized as a substrate for the serine proteases trypsin, plasmin, and thrombin. TAME hydrochloride is an inhibitor of anaphase-promoting complex (APC), which binds to the APC and prevents its activation by Cdc20 and Cdh1.
  • HY-101214
    UK-371804 Inhibitor >98.0%
    UK-371804 is a urokinase-type plasminogen activator (uPA) inhibitor with a Ki of 10 nM.
  • HY-B0190
    Nafamostat Inhibitor
    Nafamostat, a synthetic serine protease inhibitor, is an anticoagulant. Nafamostat supresses T cell auto-reactivity by decreasing granzyme activity and CTL cytolysis.
  • HY-B0190B
    Nafamostat hydrochloride Inhibitor
    Nafamostat hydrochloride, a synthetic serine protease inhibitor, is an anticoagulant. Nafamostat hydrochloride supresses T cell auto-reactivity by decreasing granzyme activity and CTL cytolysis.
Isoform Specific Products

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