1. Metabolic Enzyme/Protease
  2. Ser/Thr Protease
  3. Benzamidine hydrochloride

Benzamidine hydrochloride 

Cat. No.: HY-W018781 Purity: ≥98.0%
Handling Instructions

Benzamidine hydrochloride is an reversible competitive inhibitor of trypsin-like serine proteases, with Kis of 97 µM, 21 µM, 20 µM and 110 µM for uPA, trypsin, tryptase and factor Xa, respectively.

For research use only. We do not sell to patients.

Benzamidine hydrochloride Chemical Structure

Benzamidine hydrochloride Chemical Structure

CAS No. : 1670-14-0

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
500 mg USD 50 In-stock
Estimated Time of Arrival: December 31
1 g   Get quote  
5 g   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Benzamidine hydrochloride is an reversible competitive inhibitor of trypsin-like serine proteases, with Kis of 97 µM, 21 µM, 20 µM and 110 µM for uPA, trypsin, tryptase and factor Xa, respectively[1].

IC50 & Target

Ki: 97 µM (uPA), 21 µM (trypsin), 20 µM (tryptase), 110 µM (factor Xa)[1]

In Vitro

Benzamidine hydrochloride has weak inhibition for tPA and thrombin, with Kis of 750 µM and 320 µM, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

156.61

Formula

C₇H₉ClN₂

CAS No.

1670-14-0

SMILES

[H]Cl.N=C(C1=CC=CC=C1)N

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (638.53 mM; Need ultrasonic)

H2O : 50 mg/mL (319.26 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.3853 mL 31.9264 mL 63.8529 mL
5 mM 1.2771 mL 6.3853 mL 12.7706 mL
10 mM 0.6385 mL 3.1926 mL 6.3853 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (15.96 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (15.96 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (15.96 mM); Clear solution

  • 4.

    Add each solvent one by one:  PBS

    Solubility: 110 mg/mL (702.38 mM); Clear solution; Need ultrasonic

*All of the co-solvents are provided by MCE.
References

Purity: ≥98.0%

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Keywords:

BenzamidineSer/Thr ProteaseSerine proteasesSerine endopeptidasesThreonine proteasestrypsin-likeserineproteasesuPAtrypsintryptasefactor Xaurokinase-type ,plasminogenactivatorInhibitorinhibitorinhibit

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Product Name:
Benzamidine hydrochloride
Cat. No.:
HY-W018781
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