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Leupeptin hemisulfate

62 Cited Publications
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Based on 62 publication(s) in Google Scholar

Leupeptin hemisulfate is a broad-spectrum, membrane-permeable protease inhibitor. Leupeptin hemisulfate potently inhibits serine, cysteine and threonine proteases. Leupeptin hemisulfate inhibits Mpro (the main protease of SARS-CoV-2) and also has anti-inflammatory activity.

For research use only. We do not sell to patients.

  • Purity: 99.39%
  • CAS No.: 103476-89-7
  • Formula: C20H38N6O4.1/2H2SO4
  • Molecular Weight:475.59
  • Storage:

    -20°C, sealed storage, away from moisture

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

  • Leupeptin hemisulfate Chemical Structure
    Leupeptin hemisulfate Chemical Structure
  • Experimental Validation Results for Leupeptin hemisulfate
  • Experimental Validation Results for Leupeptin hemisulfate
  • Experimental Validation Results for Leupeptin hemisulfate
  • Experimental Validation Results for Leupeptin hemisulfate
  • Experimental Validation Results for Leupeptin hemisulfate
CAS No.: 103476-89-7
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  • Leupeptin hemisulfate Chemical Structure
    Leupeptin hemisulfate Chemical Structure
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    Leupeptin hemisulfate purchased from MedChemExpress. Usage Cited in: J Hematol Oncol. 2024 Sep 2;17(1):78. [Abstract]

    Customer Validation
     The LTF expression was detected under MG132 (10 μM) or Leupeptin (100 μM) treatment.

  • 1/16

    Leupeptin hemisulfate purchased from MedChemExpress. Usage Cited in: Autophagy. 2025 Feb;21(2):352-373. [Abstract]

    Customer Validation
     Immunoblotting showing the level of PLCG1 in NPC after treatment with Leu (10 μM), NH4Cl (20 mM), or their combination for 12 h. Right panels represent normalized (/NC) band intensities of interest.

  • 1/16

    Leupeptin hemisulfate purchased from MedChemExpress. Usage Cited in: Autophagy. 2025 Feb;21(2):352-373. [Abstract]

    Customer Validation
     Western blot showing PLCG1 levels in NPC treated with a combination of Leu (10 μM) and NH4Cl (N/L) for 3, 6, and 9 h. Right panels represent normalized (/NC) band intensities of interest.

  • 1/16

    Leupeptin hemisulfate purchased from MedChemExpress. Usage Cited in: Cell Death Differ. 2023 Jan;30(1):137-151. [Abstract]

    Customer Validation
     Western blot analysis of SLC7A11, SOCS2 and tubulin proteins in SK-Hep-1 and HepG2 cells at 4 h after 4 Gy IR. Leupeptin (50 μM) were added before IR.

  • 1/16

    Leupeptin hemisulfate purchased from MedChemExpress. Usage Cited in: Autophagy. 2021 Aug;17(8):1873-1888. [Abstract]

    Customer Validation
     661 W cells were transfected with the indicated siRNA for 24 h. Then, 661 W cells were treated with 10 μg/ml Leupeptin for 24 h. Cell lysates were collected for western blot analysis of LC3B and GAPDH.

  • Leupeptin hemisulfate