Leupeptin hemisulfate (Standard)
Leupeptin hemisulfate (Standard) is the analytical standard of Leupeptin hemisulfate (HY-18234A ). This product is intended for research and analytical applications. Leupeptin hemisulfate is a broad-spectrum protease inhibitor. By inhibiting the activation of the PTEN/PI3K/Akt/NF-κB/ERK1/2/p38 signaling pathway, Leupeptin hemisulfate significantly reduces LPS-induced NO and ROS production, mitochondrial membrane potential hyperpolarization, phagocytic activity, pro-inflammatory cytokine release, and M1 polarization in mouse peritoneal macrophages, and reverses autophagic flux impairment. It also decreases Concanavalin A (HY-P2149)-induced proliferation index of mouse splenic lymphocytes and the Th1/IL-10 and Th2/IL-10 cytokine ratios, thereby modulating innate and adaptive immune responses. Leupeptin hemisulfate inhibits blood coagulation and tumorigenesis in mouse skin. Leupeptin hemisulfate can be used in research on chronic inflammatory diseases and skin tumorigenesis.
For research use only. We do not sell to patients.
- Purity : 98%
- CAS No.: 103476-89-7
- Formula: C20H38N6O4.1/2H2SO4
- Molecular Weight:475.59
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Product Information
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Chemical Information
- Purity & Documentation
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Help & FAQs
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HY-18234A
Leupeptin hemisulfateProtease Inhibitor -
HY-B0496
PMSFCathepsin Inhibitor -
HY-P0017
AprotininBPTI Inhibitor -
HY-12821
AEBSF hydrochlorideThrombin Inhibitor -
HY-100229
AloxistatinCysteine Protease Inhibitor -
HY-15282
E-64Cysteine Peptidase Inhibitor -
HY-D0843
N-EthylmaleimideCysteine Residues Modifier -
HY-P0018
PepstatinAspartic Protease Inhibitor -
HY-B0190A
Nafamostat mesylateSerine Protease Inhibitor -
HY-100350
CA-074 methyl esterCathepsin B Inhibitor -
HY-E70203
Recombinant aprotininSerine Protease Inhibitor -
HY-B0445
NAD+Endogenous Metabolite
Product Information
Information
Application
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
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CAS No. 103476-89-7
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Molecular Weight 475.59
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Formula C20H38N6O4.1/2H2SO4
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SMILES
O=C[C@@H](NC([C@@H](NC([C@@H](NC(C)=O)CC(C)C)=O)CC(C)C)=O)CCCNC(N)=N.[0.5H2SO4]
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Leupeptin hemisulfate (Standard) Related Classifications
HY-18234AR Related Classifications
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Keywords
- Leupeptin hemisulfate (Standard)
- 103476-89-7
- Reference Standards
- Ser/Thr Protease
- Cathepsin
- Autophagy
- SARS-CoV
- Atg8/LC3
- NO Synthase
- COX
- p62
- Arginase
- PTEN
- NF-κB
- PI3K
- Akt
- p38 MAPK
- ERK
- Reactive Oxygen Species (ROS)
- Serine proteases
- Serine endopeptidases
- Threonine proteases
- SARS coronavirus
- Autophagy-related 8
- Nitric oxide synthases
- NOS
- Cyclooxygenase
- Sequestosome-1
- SQSTM1
- Phosphatase and tensin homolog
- MMAC1
- Nuclear factor-κB
- Nuclear factor-kappaB
- Phosphoinositide 3-kinase
- PKB
- Protein kinase B
- Extracellular signal regulated kinases
- kallikrein
- cathepsins B
- L
- and H
- LPS-induced mitochondrial membrane potential hyperpolarization
- mouse skin
- papain
- chymotrypsin
- mouse hepatocytes
- trypsin
- beclin 1+/- mouse liver
- plasmin
- Inhibitor
- inhibitor
- inhibit