1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. NAD+

NAD+  (Synonyms: β-DPN; β-NAD; β-Nicotinamide Adenine Dinucleotide)

Cat. No.: HY-B0445 Purity: 99.86%
COA Handling Instructions

NAD+ is a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage.

For research use only. We do not sell to patients.

NAD+ Chemical Structure

NAD+ Chemical Structure

CAS No. : 53-84-9

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in Water
ready for reconstitution
USD 55 In-stock
Solution
10 mM * 1 mL in Water USD 55 In-stock
Solid
500 mg USD 50 In-stock
1 g USD 60 In-stock
5 g USD 180 In-stock
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50 g   Get quote  

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Customer Review

Based on 22 publication(s) in Google Scholar

Other Forms of NAD+:

Top Publications Citing Use of Products

    NAD+ purchased from MedChemExpress. Usage Cited in: Vascul Pharmacol. 2022 Nov 6;147:107126.  [Abstract]

    NAD+ significantly improves the expression of CD31 in the MI mice and DM + MI mice.

    NAD+ purchased from MedChemExpress. Usage Cited in: Vascul Pharmacol. 2022 Nov 6;147:107126.  [Abstract]

    NAD+ significantly improves the expression of VEGF in the MI mice and DM + MI mice.
    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    NAD+ is a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage.

    IC50 & Target

    Human Endogenous Metabolite

     

    In Vitro

    NAD+ is a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. NAD+ is the oxidized form of NADH[1]. NAD+ is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (Nadide) [2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    In Vivo

    Oral NAD+ supplementation has been used to combat simple fatigue as well as such mysterious and energy-sapping disorders as chronic fatigue syndrome and fibromyalgia[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Clinical Trial
    Molecular Weight

    663.43

    Formula

    C21H27N7O14P2

    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O[C@H]([C@@H]1O)[C@@H](O[C@@H]1COP(OP(OC[C@H]2O[C@@H]([N+]3=CC=CC(C(N)=O)=C3)[C@H](O)[C@@H]2O)([O-])=O)(O)=O)N4C(N=CN=C5N)=C5N=C4

    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 1 year
    -20°C 6 months
    Solvent & Solubility
    In Vitro: 

    H2O : 41.67 mg/mL (62.81 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.5073 mL 7.5366 mL 15.0732 mL
    5 mM 0.3015 mL 1.5073 mL 3.0146 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 1 years; -20°C, 6 months. When stored at -80°C, please use it within 1 years. When stored at -20°C, please use it within 6 months.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo:

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 100 mg/mL (150.73 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.86%

    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 1 years; -20°C, 6 months. When stored at -80°C, please use it within 1 years. When stored at -20°C, please use it within 6 months.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 1.5073 mL 7.5366 mL 15.0732 mL 37.6830 mL
    5 mM 0.3015 mL 1.5073 mL 3.0146 mL 7.5366 mL
    10 mM 0.1507 mL 0.7537 mL 1.5073 mL 3.7683 mL
    15 mM 0.1005 mL 0.5024 mL 1.0049 mL 2.5122 mL
    20 mM 0.0754 mL 0.3768 mL 0.7537 mL 1.8841 mL
    25 mM 0.0603 mL 0.3015 mL 0.6029 mL 1.5073 mL
    30 mM 0.0502 mL 0.2512 mL 0.5024 mL 1.2561 mL
    40 mM 0.0377 mL 0.1884 mL 0.3768 mL 0.9421 mL
    50 mM 0.0301 mL 0.1507 mL 0.3015 mL 0.7537 mL
    60 mM 0.0251 mL 0.1256 mL 0.2512 mL 0.6280 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    NAD+ Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    Product Name:
    NAD+
    Cat. No.:
    HY-B0445
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