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NAD+ lithium  (Synonyms: β-DPN lithium; β-NAD lithium; β-Nicotinamide Adenine Dinucleotide lithium)

Cat. No.: HY-W250163 Purity: 99.49%
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NAD+ lithium (β-DPN lithium) is a lithium salt of nicotinamide adenine dinucleotide. NAD+ is a coenzyme in the REDOX reaction. NAD+ can directly or indirectly affect several key cellular functions, including metabolic pathways, DNA repair, chromatin remodeling, cell aging, and immune cell function.

For research use only. We do not sell to patients.

CAS No. : 64417-72-7

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
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10 mM * 1 mL in Water In-stock
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Customer Review

Based on 44 publication(s) in Google Scholar

Other Forms of NAD+ lithium:

NAD+ lithium Related Antibodies

Top Publications Citing Use of Products

44 Publications Citing Use of MCE NAD+ lithium

Cell Proliferation/Viability Assay
IP
RT-PCR
WB
IF

    NAD+ lithium purchased from MedChemExpress. Usage Cited in: Redox Biol. 2024 Feb:69:103030.  [Abstract]

    LDH release assay showed the glioma cell death caused by SRT2183 (40 μmol/L) at 24 h was attenuated when the cells were pretreated 1 h with EX527 (200 μmol/L) or supplemented with exogenous NAD+ (2 mmol/L).

    NAD+ lithium purchased from MedChemExpress. Usage Cited in: Redox Biol. 2024 Feb:69:103030.  [Abstract]

    The declines of cysteine induced by SRT2183 (40 μmol/L) at 24 h were both suppressed by pretreating the cells 1 h with EX527 or supplementing exogenous NAD+ (2 mmol/L).

    NAD+ lithium purchased from MedChemExpress. Usage Cited in: Redox Biol. 2024 Feb:69:103030.  [Abstract]

    Western blotting revealed RSL3-induced downregulation of SLC7A11 and GPX4 was enhanced by FK866, but attenuated by exogenous NAD+ (2 mmol/L) supplement.

    NAD+ lithium purchased from MedChemExpress. Usage Cited in: Redox Biol. 2024 Feb:69:103030.  [Abstract]

    Pretreatment with FK866 (500 μmol/L) or supplement of exogenous NAD+ at 2 mmol/L for 1 h prevented RSL3-induced upregulation of ATF3 in both cytoplasmic and nuclear fractions.

    NAD+ lithium purchased from MedChemExpress. Usage Cited in: Redox Biol. 2024 Feb:69:103030.  [Abstract]

    Supplement of exogenous NAD+ at 1 mmol/L could inhibit ATF3 upregulation in the cells treated with FK866 (500 μmol/L) for 24 h, and this inhibition became more apparent by increasing NAD+ dosage to 2 mmol/L.

    NAD+ lithium purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2023 Oct;44(10):2125-2138.  [Abstract]

    Western blotting proved supplement of exterior NAD+ (0.5-2 mmol/L, 1 h) dosage-dependently alleviated DPT-induced downregulation of phospho-AKT and upregulation of NOX2, NAT10, phospho-CREB, PARP1, and PAR.

    NAD+ lithium purchased from MedChemExpress. Usage Cited in: Vascul Pharmacol. 2022 Dec:147:107126.  [Abstract]

    NAD+ significantly improves the expression of CD31 in the MI mice and DM + MI mice.

    NAD+ lithium purchased from MedChemExpress. Usage Cited in: Vascul Pharmacol. 2022 Dec:147:107126.  [Abstract]

    NAD+ significantly improves the expression of VEGF in the MI mice and DM + MI mice.

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    NAD+ lithium (β-DPN lithium) is a lithium salt of nicotinamide adenine dinucleotide. NAD+ is a coenzyme in the REDOX reaction. NAD+ can directly or indirectly affect several key cellular functions, including metabolic pathways, DNA repair, chromatin remodeling, cell aging, and immune cell function[1].

    Molecular Weight

    669.36

    Formula

    C21H26LiN7O14P2
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O[C@H]1[C@@H](O[C@@H]([C@H]1O)COP(OP(OC[C@H]2O[C@@H]([N+]3=CC=CC(C(N)=O)=C3)[C@@H]([C@@H]2O)O)([O-])=O)(O[Li])=O)N4C5=NC=NC(N)=C5N=C4
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    H2O : 100 mg/mL (149.40 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.4940 mL 7.4698 mL 14.9396 mL
    5 mM 0.2988 mL 1.4940 mL 2.9879 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    This equation is commonly abbreviated as: C1V1 = C2V2

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    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.49%

    SDS (396 KB)

    COA (248 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 1.4940 mL 7.4698 mL 14.9396 mL 37.3491 mL
    5 mM 0.2988 mL 1.4940 mL 2.9879 mL 7.4698 mL
    10 mM 0.1494 mL 0.7470 mL 1.4940 mL 3.7349 mL
    15 mM 0.0996 mL 0.4980 mL 0.9960 mL 2.4899 mL
    20 mM 0.0747 mL 0.3735 mL 0.7470 mL 1.8675 mL
    25 mM 0.0598 mL 0.2988 mL 0.5976 mL 1.4940 mL
    30 mM 0.0498 mL 0.2490 mL 0.4980 mL 1.2450 mL
    40 mM 0.0373 mL 0.1867 mL 0.3735 mL 0.9337 mL
    50 mM 0.0299 mL 0.1494 mL 0.2988 mL 0.7470 mL
    60 mM 0.0249 mL 0.1245 mL 0.2490 mL 0.6225 mL
    80 mM 0.0187 mL 0.0934 mL 0.1867 mL 0.4669 mL
    100 mM 0.0149 mL 0.0747 mL 0.1494 mL 0.3735 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    NAD+ lithium Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    NAD+64417-72-7β-DPNβ-NADβ-Nicotinamide Adenine DinucleotideBiochemical Assay Reagentsbiochemical reagentbiological materialorganic compoundlife scienceInhibitorinhibitorinhibit

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