1. Immunology/Inflammation
  2. SPHK

SPHK

SphK (sphingosine kinase) is the major source of the bioactive lipid and GPCR (G-protein-coupled receptor) agonist S1P (sphingosine 1-phosphate). S1P promotes cell growth, survival and migration, and is a key regulator of lymphocyte trafficking. Inhibition of S1P signalling has been proposed as a strategy for treatment of inflammatory diseases and cancer.

S1P is an extracellular ligand at five cognate GPCRs, S1PRs and a consequential intracellular lipid intermediate that affects diverse cellular processes including migration, growth and survival. S1P regulates function and trafficking of immune cells, induces angiogenesis and regulates endothelial cell functions, promotes survival and migration of cancer cells, and has been implicated as an important mediator in the pathogenesis of cancer and autoimmune and allergic diseases.

SPHK Related Products (10):

Cat. No. Product Name Effect Purity
  • HY-12005
    Fingolimod hydrochloride Antagonist 99.57%
    Fingolimod hydrochloride is a sphingosine 1-phosphate (S1P) antagonist with IC50 of 0.033 nM in K562 and NK cells.
  • HY-16015
    ABC294640 Inhibitor 99.68%
    ABC294640 is a selective, competitive sphingosine kinase 2 (SK2) inhibitor with Ki of 9.8 μM.
  • HY-15779A
    K145 hydrochloride Inhibitor 98.00%
    K145 is a selective SphK2 inhibitor with an IC50 of 4.30±0.06 μM , while no inhibition of SphK1 at concentrations up to 10 μM.
  • HY-15425A
    PF-543 Citrate Inhibitor 99.21%
    PF-543 Citrate is a novel cell-permeant inhibitor of SPHK1 with a Ki of 4.3 nM and more than 100-fold selectivity for SPHK1 over SPHK2.
  • HY-13822
    SKI II Inhibitor 98.69%
    SKI-II is a synthetic inhibitor of sphingosine kinase (SK) activity with IC50 of 78 μM for SK1 and 45 μM for SK2.
  • HY-101805
    SK1-IN-1 Inhibitor >98.0%
    SK1-IN-1 is a potent sphingosine kinase 1 (SPHK1) inhibitor with an IC50 of 58 nM.
  • HY-11063
    Fingolimod Antagonist
    Fingolimod is a sphingosine 1-phosphate (S1P) antagonist with IC50 of 0.033 nM in K562 and NK cells.
  • HY-15779
    K145 Inhibitor
    K145 is a selective SphK2 inhibitor with an IC50 of 4.30±0.06 μM , while no inhibition of SphK1 at concentrations up to 10 μM.
  • HY-19794
    MP-A08 Inhibitor
    MP-A08 is a highly selective ATP competitive SK inhibitor that targets both SK1 and SK2 with Kivalues of 6.9 ± 0.8 μM and 27 ± 3 μM, respectively.
  • HY-15425
    PF-543 Inhibitor
    PF-543 is a novel cell-permeant inhibitor of SPHK1 with a Ki of 4.3 nM and more than 100-fold selectivity for SPHK1 over SPHK2.