1. Epigenetics
    TGF-beta/Smad
  2. PKC
  3. PKCα Inhibitors

PKCα Inhibitors

PKC

PKCα

PKCβ

PKCγ

PKCδ

PKCε

PKCη

PKCζ

PKCθ

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform PKCα together.

Please try each isoform separately.

PKCα Specific Inhibitors
Product Name PKCα PKC PKCβ PKCγ PKCδ PKCε PKCη PKCζ PKCθ PKCα Selectivity Purity
VTX-27
PKCα, Ki: 356 nM
     
PKCδ, Ki: 16 nM
     
PKCθ, Ki: 0.08 nM
Selective Inhibitor 99.68%
LXS196
PKCα, IC50: 1.9 nM
             
PKCθ, IC50: 0.4 nM
Selective Inhibitor 99.25%
Midostaurin
cPKC-α, IC50: 22 nM
 
cPKC-β1, IC50: 30 nM
cPKC-β2, IC50: 31 nM
cPKC-γ, IC50: 24 nM
nPKC-δ, IC50: 33 nM
nPKC-ε, IC50: 1250 nM
nPKC-η, IC50: 16 nM
aPKC-ζ, IC50: 465000 nM
  Pan Inhibitor 99.85%
Bisindolylmaleimide I
PKCα, IC50: 20 nM
Bovine brain PKC, IC50: 10 nM
PKCβII, IC50: 16 nM
PKCβI, IC50: 17 nM
PKCγ, IC50: 20 nM
          Pan Inhibitor 98.04%
Sotrastaurin
PKCα, Ki: 0.95 nM
 
PKCβI, Ki: 0.64 nM
 
PKCδ, Ki: 2.1 nM
PKCε, Ki: 3.2 nM
PKCη, Ki: 1.8 nM
 
PKCθ, Ki: 0.22 nM
Pan Inhibitor 99.83%
Ro 31-8220 mesylate
PKC-α, IC50: 5 nM
Rat Brain PKC, IC50: 23 nM
PKC-βI, IC50: 24 nM
PKC-βII, IC50: 14 nM
PKC-γ, IC50: 27 nM
 
PKC-ε, IC50: 24 nM
      Pan Inhibitor 99.28%
Ruboxistaurin hydrochloride
PKCα, IC50: 360 nM
 
PKCβI, IC50: 4.7 nM
PKCβII, IC50: 5.9 nM
PKCγ, IC50: 300 nM
PKCδ, IC50: 250 nM
PKCε, IC50: 600 nM
PKCη, IC50: 52 nM
    Pan Inhibitor 98.88%
Rottlerin
PKCα, IC50: 30 μM (baculovirus-infected Sf9 insect cells)
 
PKCβ, IC50: 42 μM (baculovirus-infected Sf9 insect cells)
PKCγ, IC50: 40 μM (baculovirus-infected Sf9 insect cells)
PKCδ, IC50: 3 μM (Porcine spleen)
PKCε, IC50: 100 μM (baculovirus-infected Sf9 insect cells)
PKCη, IC50: 82 μM (baculovirus-infected Sf9 insect cells)
PKCζ, IC50: 100 μM (baculovirus-infected Sf9 insect cells)
  Pan Inhibitor >95.0%
AS2521780
PKCα, IC50: 160 nM
     
PKCδ, IC50: 160 nM
PKCε, IC50: 18 nM
   
PKCθ, IC50: 0.48 nM
Pan Inhibitor