PKCα

PKCα Related Products (32):

By Type:	Pan (26) Selective (5)
By Effects:	Inhibitors (31) Modulator (1)

Cat. No.	Product Name	Effect	Purity

HY-13689

Go 6983	Inhibitor	98.42%
Go 6983 is a pan-PKC inhibitor against for PKCα, PKCβ, PKCγ, PKCδ and PKCζ with IC₅₀ of 7 nM, 7 nM, 6 nM, 10 nM and 60 nM, respectively.

HY-10230

Midostaurin	Inhibitor	99.95%
Midostaurin (PKC412; CGP 41251) is an orally active, reversible multi-targeted protein kinase inhibitor.

HY-13867

Bisindolylmaleimide I	Inhibitor	99.03%
Bisindolylmaleimide I (GF109203X) is a cell-permeable and reversible PKC inhibitor (IC₅₀ of 20 nM, 17 nM, 16 nM, and 20 nM for PKCα, PKCβI, PKCβII, and PKCγ.

HY-10343

Sotrastaurin	Inhibitor	99.89%
Sotrastaurin (AEB071) is a potent and orally-active pan-PKC inhibitor, with K_is of 0.22 nM, 0.64 nM, 0.95 nM, 1.8 nM, 2.1 nM and 3.2 nM for PKCθ, PKCβ, PKCα, PKCη, PKCδ and PKCε, respectively.

HY-18980

Rottlerin	Inhibitor	98.15%
Rottlerin, a natural product purified from Mallotus Philippinensis, is a specific PKC inhibitor, with IC₅₀ values for PKCδ of 3-6 μM, PKCα,β,γ of 30-42 μM, PKCε,η,ζ of 80-100 μM.

HY-10195A

Ruboxistaurin mesylate	Inhibitor
Ruboxistaurin (LY333531) mesylate is an orally active, selective and ATP competitive PKCβ inhibitor with IC₅₀ values of 4.7 and 5.9 nM for PKCβI and PKCβII, respectively.

HY-13867A

Bisindolylmaleimide I hydrochloride	Inhibitor	99.18%
Bisindolylmaleimide I (GF109203X) hydrochloride is a cell-permeable and reversible PKC inhibitor (IC₅₀ of 20 nM, 17 nM, 16 nM, and 20 nM for PKCα, PKCβI, PKCβII, and PKCγ.

HY-121197

Balanol	Inhibitor
Balanol (Ophiocordin; Azepinostatin) is a potent and ATP competitive PKC/PKA inhibitor against human PKC isozymes α, β-I, β-II, γ, δ, ε, η (IC₅₀s=4-9 nM) and ζ (IC₅₀=150 nM).

HY-10342

Enzastaurin	Inhibitor	99.92%
Enzastaurin (LY317615) is a potent and selective PKCβ inhibitor with an IC₅₀ of 6 nM, showing 6- to 20-fold selectivity over PKCα, PKCγ and PKCε.

HY-13866

Ro 31-8220 mesylate	Inhibitor	99.28%
Ro 31-8220 mesylate is a potent PKC inhibitor, with IC₅₀s of 5, 24, 14, 27, 24 and 23 nM for PKCα, PKCβI, PKCβII, PKCγ, PKCε and rat brain PKC, respectively.

HY-B0719

Ingenol Mebutate	Modulator	99.41%
Ingenol Mebutate is an active ingredient in Euphorbia peplus, acts as a potent PKC modulator, with K_is of 0.3, 0.105, 0.162, 0.376, and 0.171 nM for PKC-α, PKC-β, PKC-γ, PKC-δ, and PKC-ε, respectively, and has antiinflammatory and antitumor activity.

HY-112782

VTX-27	Inhibitor	99.64%
VTX-27 is a selective protein kinase C θ (PKC θ) inhibitor, with K_is of 0.08 nM and 16 nM for PKC θ and PKC δ.

HY-101569

Darovasertib	Inhibitor	99.68%
Darovasertib (LXS196) is a potent, selective and orally active protein kinase C (PKC) inhibitor, with IC₅₀ values of 1.9 nM, 0.4 nM and 3.1 μM for PKCα, PKCθ and GSK3β, respectively.

HY-10195

Ruboxistaurin	Inhibitor	99.90%
Ruboxistaurin (LY333531) is an orally active, selective PKC beta inhibitor (K_i=2 nM).

HY-13335

PKCβ inhibitor 1	Inhibitor	99.40%
PKCβ inhibitor 1 is a potent, ATP-competitive, and selective PKCβ inhibitor with IC₅₀s of 21 and 5 nM for human PKCβ1 and PKCβ2, respectively.

HY-117800

BJE6-106	Inhibitor	99.93%
BJE6-106 (B106) is a potent, selective 3^rd generation PKCδ inhibitor with an IC₅₀ of 0.05 μM and targets selectivity over classical PKC isozyme PKCα (IC₅₀=50 μM).

HY-103045

CMPD101	Inhibitor	98.74%
CMPD101 is a potent, highly selective and membrane-permeable small-molecule inhibitor of GRK2/3 with IC₅₀ of 18 nM and 5.4 nM, respectively.

HY-10195B

Ruboxistaurin hydrochloride	Inhibitor	99.84%
Ruboxistaurin (LY333531) hydrochloride is an orally active, selective PKC beta inhibitor (K_i=2 nM).

HY-108264

TCS 21311	Inhibitor	99.18%
TCS 21311 (NIBR3049) is a potent, highly selective JAK3 inhibitor with an IC₅₀ of 8 nM, it displays >100-fold selectivity over JAK1, JAK2 and TYK2.

HY-117610A

Bisindolylmaleimide XI hydrochloride	Inhibitor	≥98.0%
Bisindolylmaleimide XI hydrochloride (Ro 32-0432) is a potent, selective and orally active PKC inhibitor with IC₅₀s of 9 nM, 28 nM, 31 nM, 37 nM, and 108 nM for PKCα, PKCβI, PKCβII, PKCγ, and PKCε, respectively.

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