1. Signaling Pathways
  2. Epigenetics
    TGF-beta/Smad
  3. PKC
  4. PKCα Inhibitors

PKCα Inhibitors

PKC

PKCα

PKCβ

PKCγ

PKCδ

PKCε

PKCη

PKCζ

PKCθ

PKCμ

PKCι

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Sorry. There is currently no product that acts on isoform PKCα together.

Please try each isoform separately.

PKCα Specific Inhibitors & Modulators
Product Name PKCα PKC PKCβ PKCγ PKCδ PKCε PKCη PKCζ PKCθ PKCμ PKCα Selectivity Purity
CMPD101
PKCα, IC50: 8.1 μM
                  Selective Inhibitor ≥98.0%
VTX-27
PKCα, Ki: 356 nM
     
PKCδ, Ki: 16 nM
     
PKCθ, Ki: 0.08 nM
  Selective Inhibitor 99.64%
BJE6-106
PKCα, IC50: 50 μM
     
PKCδ, IC50: 0.05 μM
          Selective Inhibitor 98.17%
PKC-theta inhibitor 1
PKCα, Ki: 1020 μM
     
PKCδ, Ki: 392 μM
     
PKCθ, Ki: 6 nM
  Selective Inhibitor
Leucosceptoside A
PKCα, IC50: 19 μM
                  Selective Inhibitor
Go 6983
PKCα, IC50: 7 nM
 
PKCβ, IC50: 7 nM
PKCγ, IC50: 6 nM
PKCδ, IC50: 10 nM
   
PKCζ, IC50: 60 nM
 
PKCμ, IC50: 20000 nM
Pan Inhibitor 98.01%
Midostaurin
cPKC-α, IC50: 22 nM
 
cPKC-β1, IC50: 30 nM
cPKC-β2, IC50: 31 nM
cPKC-γ, IC50: 24 nM
nPKC-δ, IC50: 33 nM
nPKC-ε, IC50: 1250 nM
nPKC-η, IC50: 160 nM
aPKC-ζ, IC50: 465000 nM
    Pan Inhibitor ≥98.0%
Ruboxistaurin
PKCα, IC50: 360 nM
 
PKC-βI, IC50: 4.7 nM
PKC-βII, IC50: 5.9 nM
PKCγ, IC50: 300 nM
PKCδ, IC50: 250 nM
PKCε, IC50: 600 nM
PKCη, IC50: 52 nM
      Pan Inhibitor 98.03%
Bisindolylmaleimide I
PKCα, IC50: 20 nM
Bovine brain PKC, IC50: 10 nM
PKCβII, IC50: 16 nM
PKCβI, IC50: 17 nM
PKCγ, IC50: 20 nM
            Pan Inhibitor 98.14%
Sotrastaurin
PKCα, Ki: 0.95 nM
 
PKCβI, Ki: 0.64 nM
 
PKCδ, Ki: 2.1 nM
PKCε, Ki: 3.2 nM
PKCη, Ki: 1.8 nM
 
PKCθ, Ki: 0.22 nM
  Pan Inhibitor 99.89%
Rottlerin
PKCα, IC50: 30 μM (baculovirus-infected Sf9 insect cells)
 
PKCβ, IC50: 42 μM (baculovirus-infected Sf9 insect cells)
PKCγ, IC50: 40 μM (baculovirus-infected Sf9 insect cells)
PKCδ, IC50: 3 μM (Porcine spleen)
PKCε, IC50: 100 μM (baculovirus-infected Sf9 insect cells)
PKCη, IC50: 82 μM (baculovirus-infected Sf9 insect cells)
PKCζ, IC50: 100 μM (baculovirus-infected Sf9 insect cells)
    Pan Inhibitor ≥95.0%
Enzastaurin
PKCα, IC50: 39 nM
 
PKCβ, IC50: 6 nM
PKCγ, IC50: 83 nM
 
PKCε, IC50: 110 nM
        Pan Inhibitor 99.92%
Ro 31-8220 mesylate
PKC-α, IC50: 5 nM
Rat Brain PKC, IC50: 23 nM
PKC-βI, IC50: 24 nM
PKC-βII, IC50: 14 nM
PKC-γ, IC50: 27 nM
 
PKC-ε, IC50: 24 nM
        Pan Inhibitor ≥98.0%
Ingenol Mebutate
PKC-α, Ki: 0.3 nM
 
PKC-β, Ki: 0.105 nM
PKC-γ, Ki: 0.162 nM
PKC-δ, Ki: 0.376 nM
PKC-ε, Ki: 0.171 nM
        Pan Modulator 99.07%
Darovasertib
PKCα, IC50: 1.9 nM
             
PKCθ, IC50: 0.4 nM
  Pan Inhibitor 99.68%
Ruboxistaurin hydrochloride
PKCα, IC50: 360 nM
 
PKCβI, IC50: 4.7 nM
PKCβII, IC50: 5.9 nM
PKCγ, IC50: 300 nM
PKCδ, IC50: 250 nM
PKCε, IC50: 600 nM
PKCη, IC50: 52 nM
      Pan Inhibitor 99.84%
PKCβ inhibitor 1
PKCα, IC50: 331 nM
 
human PKCβ1, IC50: 21 nM
human PKCβ2, IC50: 5 nM
              Pan Inhibitor 98.21%
TCS 21311
PKCα, IC50: 13 nM
             
PKCθ, IC50: 68 nM
  Pan Inhibitor ≥98.0%
Bisindolylmaleimide VIII acetate
PKC-α, IC50: 53 nM
Rat Brain PKC, IC50: 158 nM
PKC-βI, IC50: 195 nM
PKC-βII, IC50: 163 nM
PKC-γ, IC50: 213 nM
 
PKC-ε, IC50: 175 nM
        Pan Inhibitor ≥99.0%
HBDDE
PKCα, IC50: 43 μM
   
PKCγ, IC50: 50 μM
            Pan Inhibitor
Bisindolylmaleimide XI hydrochloride
PKC-α, IC50: 9 nM
 
PKC-βI, IC50: 28 nM
PKC-βII, IC50: 31 nM
PKC-γ, IC50: 37 nM
 
PKC-ε, IC50: 108 nM
        Pan Inhibitor
PF-04577806
PKCα, IC50: 2.4 nM
 
PKCβI, IC50: 8.1 nM
PKCβII, IC50: 6.9 nM
PKCγ, IC50: 45.9 nM
PKCδ, IC50: 586 nM
PKCε, IC50: 522 nM
   
PKCθ, IC50: 29.5 nM
  Pan Inhibitor
AS2521780
PKCα, IC50: 160 nM
     
PKCδ, IC50: 160 nM
PKCε, IC50: 18 nM
   
PKCθ, IC50: 0.48 nM
  Pan Inhibitor
PF-03622905
PKCα, IC50: 5.6 nM
 
PKCβI, IC50: 14.5 nM
PKCβII, IC50: 13 nM
PKCγ, IC50: 37.7 nM
       
PKCθ, IC50: 74.1 nM
  Pan Inhibitor
Ro 32-0432 hydrochloride
PKCα, IC50: 9.3 nM
 
PKC-βI, IC50: 28 nM
PKC-βII, IC50: 30 nM
PKCγ, IC50: 36.5 nM
 
PKCε, IC50: 108.3 nM
        Pan Inhibitor