1. Signaling Pathways
  2. Epigenetics
    JAK/STAT Signaling
    Stem Cell/Wnt
  3. JAK
  4. JAK2 Inhibitors

JAK2 Inhibitors

JAK1

JAK2

JAK3

Tyk2

JAK

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Sorry. There is currently no product that acts on isoform JAK2 together.

Please try each isoform separately.

JAK2 Specific Inhibitors
Product Name JAK2 JAK1 JAK3 Tyk2 JAK2 Selectivity Purity
Fedratinib hydrochloride hydrate
JAK2, IC50: 3 nM
JAK2(V617F), IC50: 3 nM
      Selective Inhibitor 99.31%
Fedratinib
JAK2, IC50: 3 nM
JAK2(V617F), IC50: 3 nM
      Selective Inhibitor 99.90%
WP1066
JAK2
      Selective Inhibitor 99.90%
SB1317
JAK2, IC50: 73 nM
      Selective Inhibitor 99.96%
Gandotinib
JAK2, IC50: 3 nM
 
JAK3, IC50: 48 nM
Tyk2, IC50: 44 nM
Selective Inhibitor 99.96%
Lestaurtinib
JAK2, IC50: 0.9 nM
      Selective Inhibitor 99.82%
CHZ868
JAK2, IC50: 110 nM
      Selective Inhibitor 99.22%
Cucurbitacin I
JAK2
      Selective Inhibitor >98.0%
TG101209
JAK2, IC50: 6 nM
 
JAK3, IC50: 169 nM
  Selective Inhibitor 99.72%
CEP-33779
JAK2, IC50: 1.8 nM
 
JAK3, IC50: 150 nM
  Selective Inhibitor 98.04%
Ilginatinib
JAK2, IC50: 0.72 nM
JAK1, IC50: 33 nM
JAK3, IC50: 39 nM
Tyk2, IC50: 22 nM
Selective Inhibitor 99.15%
BMS-911543
JAK2, IC50: 1.1 nM
JAK1, IC50: 75 nM
JAK3, IC50: 360 nM
Tyk2, IC50: 66 nM
Selective Inhibitor 97.80%
NVP-BSK805 dihydrochloride
JAK2 JH1, IC50: 0.48 nM
FL JAK2 V617F, IC50: 0.56 nM
FL JAK2 wt, IC50: 0.58 nM
JAK1 JH1, IC50: 31.63 nM
JAK3 JH1, IC50: 18.68 nM
TYK2 JH1, IC50: 10.76 nM
Selective Inhibitor 99.36%
XL019
JAK2, IC50: 2.2 nM
 
JAK3, IC50: 214.2 nM
  Selective Inhibitor >98.0%
Ilginatinib hydrochloride
JAK2, IC50: 0.72 nM
JAK1, IC50: 33 nM
JAK3, IC50: 39 nM
Tyk2, IC50: 22 nM
Selective Inhibitor 98.02%
NSC 42834
JAK2-WT, IC50: 15 μM
JAK2-V617F, IC50: 28 μM
      Selective Inhibitor 96.79%
Ilginatinib maleate
JAK2, IC50: 0.72 nM
JAK1, IC50: 33 nM
JAK3, IC50: 39 nM
Tyk2, IC50: 22 nM
Selective Inhibitor 97.04%
Ruxolitinib
JAK2, IC50: 2.8 nM
JAK1, IC50: 3.3 nM
JAK3, IC50: 428 nM
Tyk2, IC50: 19 nM
Pan Inhibitor 99.99%
Tofacitinib
JAK2, IC50: 20 nM
JAK1, IC50: 112 nM
JAK3, IC50: 1 nM
  Pan Inhibitor 99.96%
Baricitinib
JAK2, IC50: 5.7 nM
JAK1, IC50: 5.9 nM
JAK3, IC50: 560 nM
Tyk2, IC50: 53 nM
Pan Inhibitor 99.97%
Upadacitinib
JAK2, IC50: 0.2 μM
JAK1, IC50: 0.043 μM
JAK3, IC50: 2.3 μM
Tyk2, IC50: 4.7 μM
Pan Inhibitor 99.96%
SHR0302
JAK2
JAK1
JAK3
Tyk2
Pan Inhibitor 99.58%
Ruxolitinib phosphate
JAK2, IC50: 2.8 nM
JAK1, IC50: 3.3 nM
JAK3, IC50: 428 nM
Tyk2, IC50: 19 nM
Pan Inhibitor 99.98%
Tofacitinib citrate
JAK2, IC50: 20 nM
JAK1, IC50: 112 nM
JAK3, IC50: 1 nM
  Pan Inhibitor 99.92%
Filgotinib
JAK2, IC50: 28 nM
JAK1, IC50: 10 nM
JAK3, IC50: 810 nM
Tyk2, IC50: 116 nM
Pan Inhibitor 99.83%
Pacritinib
JAK2V617F, IC50: 19 nM
JAK2wt, IC50: 23 nM
JAK1, IC50: 1280 nM
JAK3, IC50: 520 nM
Tyk2, IC50: 50 nM
Pan Inhibitor 99.93%
Peficitinib
JAK2, IC50: 5 nM
JAK1, IC50: 3.9 nM
JAK3, IC50: 0.7 nM
Tyk2, IC50: 4.8 nM
Pan Inhibitor 99.78%
AZD-1480
JAK2, IC50: <0.4 nM
JAK1, IC50: 1.3 nM
    Pan Inhibitor 99.37%
Delgocitinib
JAK2, IC50: 2.6 nM
JAK1, IC50: 2.8 nM
JAK3, IC50: 13 nM
Tyk2, IC50: 58 nM
Pan Inhibitor 99.14%
Momelotinib
JAK2, IC50: 18 nM
JAK1, IC50: 11 nM
JAK3, IC50: 155 nM
  Pan Inhibitor 98.93%
AT9283
JAK2, IC50: 1.2 nM
 
JAK3, IC50: 1.1 nM
  Pan Inhibitor 99.61%
Abrocitinib
JAK2, IC50: 803 nM
JAK1, IC50: 29 nM
 
Tyk2, IC50: 1253 nM
Pan Inhibitor 99.79%
Cerdulatinib
JAK2, IC50: 6 nM
JAK1, IC50: 12 nM
JAK3, IC50: 8 nM
Tyk2, IC50: 0.5 nM
Pan Inhibitor 99.00%
PF-06700841 P-Tosylate
JAK2, IC50: 77 nM
JAK1, IC50: 17 nM
JAK3, IC50: 6.9 μM
  Pan Inhibitor 99.66%
Pyridone 6
JAK2, IC50: 1 nM
Murine JAK1, IC50: 15 nM
JAK3, IC50: 5 nM
Tyk2, IC50: 1 nM
Pan Inhibitor 98.04%
Oclacitinib maleate
JAK2, IC50: 18 nM
JAK1, IC50: 10 nM
JAK3, IC50: 99 nM
Tyk2, IC50: 84 nM
Pan Inhibitor 99.65%
SAR-20347
JAK2, IC50: 26 nM
JAK1, IC50: 23 nM
JAK3, IC50: 41 nM
Tyk2, IC50: 0.6 nM
Pan Inhibitor 98.04%
Baricitinib phosphate
JAK2, IC50: 5.7 nM
JAK1, IC50: 5.9 nM
JAK3, IC50: 560 nM
Tyk2, IC50: 53 nM
Pan Inhibitor 99.91%
AZ960
JAK2, Ki: 0.45 nM
JAK2, IC50: <3 nM
 
JAK3, IC50: 9 nM
  Pan Inhibitor >98.0%
JAK/HDAC-IN-1
JAK2, IC50: 4 nM
JAK1, IC50: 4.8 nM
JAK3, IC50: 7.4 nM
Tyk2, IC50: 49 nM
Pan Inhibitor 98.04%
Decernotinib
JAK2, Ki: 13 nM
JAK1, Ki: 11 nM
JAK3, Ki: 2.5 nM
Tyk2, Ki: 11 nM
Pan Inhibitor 99.71%
JAK3-IN-1
JAK2, IC50: 1050 nM
JAK1, IC50: 896 nM
JAK3, IC50: 4.8 nM
  Pan Inhibitor 99.98%
Tyk2-IN-9
JAK2, IC50: 8 nM
JAK1, IC50: 21 nM
 
Tyk2, IC50: 6 nM
Pan Inhibitor 99.62%
Momelotinib sulfate
JAK2, IC50: 18 nM
JAK1, IC50: 11 nM
JAK3, IC50: 155 nM
  Pan Inhibitor >95.0%
PF-06263276
JAK2, IC50: 23.1 nM
JAK1, IC50: 2.2 nM
JAK3, IC50: 59.9 nM
Tyk2, IC50: 29.7 nM
Pan Inhibitor >99.0%
Reticuline
JAK2
      Pan Inhibitor 98.11%
SC99
JAK2
      Pan Inhibitor 99.07%
Protosappanin A
JAK2
      Pan 98.88%
Cerdulatinib hydrochloride
JAK2, IC50: 6 nM
JAK1, IC50: 12 nM
JAK3, IC50: 8 nM
Tyk2, IC50: 0.5 nM
Pan Inhibitor 99.54%
NSC 33994
JAK2, IC50: 60 nM (JAK2 Val617Phe kinase activity )
      Pan Inhibitor
TCS 21311
JAK2, IC50: 2.55 μM
JAK1, IC50: 1.017 μM
JAK3, IC50: 8 nM
  Pan Inhibitor >98.0%