2. Epigenetics Stem Cell/Wnt Protein Tyrosine Kinase/RTK JAK/STAT Signaling MAPK/ERK Pathway
  3. JAK STAT p38 MAPK
  4. Butyzamide

Butyzamide is an orally active activator of Mpl, a thrombopoietin (TPO) receptor. Butyzamide increases the phosphorylation level of JAK2, STAT3, STAT5 and MAPK. Butyzamide increases the level of platelets in mouse xenotransplantation assay.

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CAS No. : 1110767-45-7

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Based on 3 publication(s) in Google Scholar

Other Forms of Butyzamide:

Butyzamide Related Antibodies

Top Publications Citing Use of Products

    Butyzamide purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Sep:145:157021.  [Abstract]

    Results of SIRT3 immunofluorescence staining in Cry-treated NPCs after addition of the STAT3 activator Butyzamide (Bym) (3 μM). Butyzamide (Bym) markedly reduced the therapeutic effect of Cry in NPCs.

    Butyzamide purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Sep:145:157021.  [Abstract]

    The addition of the STAT3 activator Butyzamide (Bym) (3 μM) attenuated the activation of SIRT3 by Cry under lactate induction in NPCs.

    Butyzamide purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Sep:145:157021.  [Abstract]

    The addition of Butyzamide (Bym) (3 μM) led to a significant reduction in the antioxidant effect of Cry in NPCs.

    Butyzamide purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Sep:145:157021.  [Abstract]

    Butyzamide (Bym) (3 μM) reversed the therapeutic benefits of Cry against apoptosis in NPCs, as indicated by flow cytometry assays.

    Butyzamide purchased from MedChemExpress. Usage Cited in: Int J Nanomedicine. 2025 Dec 10:20:14753-14785.  [Abstract]

    Butyzamide (3 μM) reversed the inhibition of RGD-AuNPs-SAHA towards the JAK2/STAT3 signaling pathway and increased the phosphorylation levels of JAK2 and STAT3 in A549 cells.

    View All JAK Isoform Specific Products:

    View All Isoforms
    JAK1 JAK2 JAK3 Tyk2 JAK

    View All STAT Isoform Specific Products:

    View All Isoforms
    STAT3 STAT5 STAT6 STAT1

    View All p38 MAPK Isoform Specific Products:

    View All Isoforms
    p38 MAPK Akt1 p38α p38β MAPK13 p38δ p38γ

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Butyzamide is an orally active activator of Mpl, a thrombopoietin (TPO) receptor. Butyzamide increases the phosphorylation level of JAK2, STAT3, STAT5 and MAPK. Butyzamide increases the level of platelets in mouse xenotransplantation assay[1].

    IC50 & Target

    JAK2

     

    STAT3

     

    STAT5

     

    In Vitro

    Butyzamide (3 μM; 15 min) induces the phosphorylation of JAK2, STAT3, STAT5 and MAPK in Ba/F3-hMpl cells[1].
    Butyzamide (3 μM; 48 h) induces colony-forming unit-megakaryocyte and polyploid meggakaryocytes from human CD34+ hematopoietic progenitor cellls[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Butyzamide Related Antibodies
    In Vivo

    Butyzamide (10 mg/kg, 50 mg/kg; p.o.; once daily for 20 days) increases human platelets in NOG mice transplanted with human fetal liver-derived CD34+ cells[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Molecular Weight

    591.55

    Formula

    C29H32Cl2N2O5S
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    CCCOC(C(C)(C)C)C1=CC=CC(C2=CSC(NC(C3=CC(Cl)=C(/C=C(C(O)=O)\C)C(Cl)=C3)=O)=N2)=C1OC
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, sealed storage, away from moisture and light

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

    Solvent & Solubility
    In Vitro: 

    DMSO : 100 mg/mL (169.05 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.6905 mL 8.4524 mL 16.9047 mL
    5 mM 0.3381 mL 1.6905 mL 3.3809 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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    This equation is commonly abbreviated as: C1V1 = C2V2

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    In Vivo Dissolution Calculator
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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
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    Working solution concentration: mg/mL
    Purity & Documentation

    Purity: 99.83%

    SDS (393 KB)

    COA (252 KB) HNMR (304 KB) RP-HPLC (256 KB) LCMS (107 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 1.6905 mL 8.4524 mL 16.9047 mL 42.2619 mL
    5 mM 0.3381 mL 1.6905 mL 3.3809 mL 8.4524 mL
    10 mM 0.1690 mL 0.8452 mL 1.6905 mL 4.2262 mL
    15 mM 0.1127 mL 0.5635 mL 1.1270 mL 2.8175 mL
    20 mM 0.0845 mL 0.4226 mL 0.8452 mL 2.1131 mL
    25 mM 0.0676 mL 0.3381 mL 0.6762 mL 1.6905 mL
    30 mM 0.0563 mL 0.2817 mL 0.5635 mL 1.4087 mL
    40 mM 0.0423 mL 0.2113 mL 0.4226 mL 1.0565 mL
    50 mM 0.0338 mL 0.1690 mL 0.3381 mL 0.8452 mL
    60 mM 0.0282 mL 0.1409 mL 0.2817 mL 0.7044 mL
    80 mM 0.0211 mL 0.1057 mL 0.2113 mL 0.5283 mL
    100 mM 0.0169 mL 0.0845 mL 0.1690 mL 0.4226 mL
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    Butyzamide Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Butyzamide1110767-45-7JAKSTATp38 MAPKJanus kinaseInhibitorinhibitorinhibit

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