GP-Ib alpha/CD42b
Glycoprotein Ib alpha (CD42b), the product of GP1BA, is the ligand-capturing extracellular giant of the GPIb-IX-V complex, extended by a mucin macroglycopeptide stalk. Its N-terminal flanking domain binds the A1 domain of von Willebrand factor, enabling platelet tethering at arterial shear, and the same region also accommodates thrombin, thrombospondin-1, P-selectin and coagulation factors XI and XII. Gain-of-function mutations in this domain cause platelet-type von Willebrand disease, while biallelic loss of GP1BA yields Bernard-Soulier syndrome. The shed ectodomain, glycocalicin, circulates in plasma and is measured as a marker of platelet turnover. CD42b is thus the principal receptor through which platelets sense vascular injury before integrin-mediated aggregation.
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GP-Ib alpha/CD42b Recombinant Proteins (1)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
